The introduction of vacuum assisted closure therapy at our Institution was delayed, compared to other centers, but was strictly bound with the development of new concepts on mechanical forces (macro-mechanical, and micro-mechanical/cellular action able to modulate cells fate, one of the suggested mechanisms for vacuum assisted closure therapy effects). While working on the scientific basis of vacuum assisted closure therapy, our Center developed an ?Interaction Project? between specialties involved in hospital care, and between Hospital and Home Nursing Care.