Eugene Mirman, Scott Adsit, and Maeve Higgins learn from Dr. Leslie Dewan, an MIT alum who developed a revolutionary new nuclear reactor that's powered by nuclear waste. It's environmentally friendly, cheaper than other reactors, and it can't meltdown. She's kind of a big deal. Along the way, we learn about the social life of nuclear engineers, why BP really needs some new recruiting videos, and Guy Fieri's cooking. Hosted by Chris Duffy. Produced by Pretty Good Friends.

Live from the Bell House in Brooklyn, this is a special NYSW edition of the show. Dr. Melanie Stiassny, an ichthyologist at the American Museum of Natural History, teaches comedians Scott Adsit, Jo Firestone, and Josh Gondelman about the mysteries of the ocean (and what happens at a museum after hours). Hosted by Chris Duffy. Produced by Pretty Good Friends. 

What's inside of a black hole? How do you measure the universe? What was the first vegetable grown in space? We dive deep into these questions and more with Dr. Anca Constantin from James Madison University's Physics and Astronomy Department. Featuring comedians Maeve Higgins, Anna Drezen, and Nick Vatterott. Hosted by Chris Duffy. Produced by Pretty Good Friends.

Live from the 2015 Bay Area Science Festival, this episode features UC Berkeley's Lindsey Dougherty, a marine biologist who studies disco clams, which light up underwater. Lindsey's trying to figure out why and how these clams act like underwater disco balls. Trying to guess what she studies and learning why it's important are comedians W. Kamau Bell (CNN's "United Shades of America), Kurt Braunohler (Comedy Central), and Emmy Blotnick (@Midnight). Hosted by Chris Duffy. Produced by Pretty Good Friends.

Nate Fuller studies bats. In this special Halloween show, we go deep into caves full of guano, get bitten by vampire bats, and hear about some extremely unusual first dates. Featuring comedians Jo Firestone, Josh Sharp, and Ken Reid. Hosted by Chris Duffy. Produced by Pretty Good Friends.

Harvard Medical School's Dr. Jo Shapiro joins us to talk about her work as a throat surgeon and the head of Brigham and Women's Hospital's Center for Professionalism and Peer Support. Panelists Eugene Mirman, Scott Adsit, and Jo Firestone learn about the beautiful anatomy of the throat, the emotional stress of being a doctor, and why it can be dangerous to eat steak at a Florida IHOP. Hosted by Chris Duffy. Produced by Pretty Good Friends.

Ammon Shea has read the entire Oxford English Dictionary and the phone book cover-to-cover and written books of his own about each. In this special book festival edition of the show, we cover exotic words, the most expensive phone book in the world, and how to use etymology as a pick up line. Hosted by Chris Duffy. Produced by Julie Smith Clem and Pretty Good Friends.

Joseph Bagley is the official Boston City Archaeologist. He's in charge of preserving Boston's many historic sites, but his real passion is digging up outhouses and privies to discover what secrets they contain. Panelists Steve Almond, Myq Kaplan, and Bethany Van Delft try to get the dirt on Joe's research and learn about looting, chowder, and bowling ball based crimes. Hosted by Chris Duffy. Produced by Pretty Good Friends.

Dr. Alexandra Horowitz is the head of Barnard's Canine Cognition Lab. She's also our first ever repeat guest! She was so great the first time, we had to have her on again with our new format. Panelists Mara Wilson, H. Jon Benjamin, and Josh Gondelman try to guess what Alexandra studies and then interview her about her work. Learn the truth about alpha males, guilty dog faces, and what a dog sees in the mirror. Hosted by Chris Duffy. Produced by Pretty Good Friends.

Dr. Robert Provine is a neuroscientist who studies "curious behaviors" like sneezing, yawning, laughter, farting, and the hiccups. He teaches comedians Maeve Higgins, Seaton Smith, and Rachel Rosenthal about the science behind his studies and why comedy is so difficult to master. Hosted by Chris Duffy. Produced by Pretty Good Friends.