David Nicandri and Clay Jenkinson discuss the return journey of Lewis and Clark in 1806. Nicandri is the author of the acclaimed book, River of Promise: Lewis and Clark on the Columbia. Both scholars of the Lewis and Clark Expedition, Clay and David explore the challenges of getting the Corps of Discovery back from the Pacific coast to St. Louis. The men were not in great physical or mental condition in March 1806. The expedition had distributed all of its "Indian gifts" on the outbound journey. The expedition was thus essentially bankrupt with almost 4,000 miles to trek across the American West. Nicandri believes Captain Meriwether Lewis was having a slow motion nervous breakdown on the return journey.

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Thomas Jefferson is interpreted and portrayed by Clay S. Jenkinson.