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What if the biggest transformation in digital pathology this year had nothing to do with new hardware—and everything to do with how we think about value, workflow, and readiness?

In this year-end recap livestream from the 11th Digital Pathology & AI Congress in London, I break down what truly mattered in 2025. Instead of focusing on buzzwords or hype cycles, this episode highlights the practical advances shaping diagnostics, patient care, and drug development—and the mindset shift our field must embrace to move forward.

Digital pathology is no longer “early adoption.” It’s becoming essential infrastructure. And yet the biggest barrier isn’t scanners or algorithms—it’s the knowledge and confidence needed to use them well.

Key Highlights & Timestamps

0:00 — Setting the Stage from London

An overview of the forces that shaped digital pathology in 2025: workflow integration, clinical readiness, and the move from theory to operational reality.

1:45 — Leica’s Expanded Portfolio & FDA-Cleared Collaborations

A look at Leica’s updated scanner lineup and co-developed, FDA-cleared solutions with Indicollabs. These launches reflect a broader industry trend toward highly specialized, clinically validated digital tools designed for end-to-end workflows.

4:12 — The Acceleration of Companion Diagnostics

From Artera’s de novo–approved prostate prognostic test to AstraZeneca’s TROP2 scoring efforts, 2025 pushed computational pathology directly into therapeutic decision-making.

6:20 — Why Workflow Integration Became the Theme of 2025

Partnerships like BioCare + Hamamatsu + Visgen and Zeiss + MindPeak show where the field is heading: full-stack solutions, not isolated tools. Labs want interoperability, reliability, and simplified digital workflows.

9:10 — Adoption Challenges: ROI, Education & AI Uncertainty

We explore the realities slowing digital transformation:
 – ROI is real, but requires workflow change
 – AI anxiety persists among clinicians and patients
 – Education is still the strongest driver of adoption

12:00 — 2025’s Innovation Highlights

Breakthroughs shaping the next phase of digital pathology include:
 – emerging agentic AI platforms
– voice-enabled image management systems
– improved multiplexing technologies like Hamamatsu’s Moxiplex

15:40 — The Growing Intersection of Pathology & Genomics

AI models predicting genomic alterations from H&E images gained traction, especially for cases with minimal tissue. Tempus acquiring Paige signals the deepening connection between digital workflows and molecular data.

18:30 — What 2026 Will Require

Priorities for the coming year include:
 – building agentic AI solutions capable of real workflow orchestration
 – strengthening validation and QC
 – sharing real-world deployment case studies
 – expanding training and hands-on learning

RESOURCES:

1. The Lucerne Toolbox 3: digital health and artificial intelligence to optimise the patient journey in early breast cancer-a multidisciplinary consensus

2. Artificial intelligence (AI) molecular analysis tool assists in rapid treatment decision in lung cancer: a case report

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