Title: Say “goodbye” to tumor resistance

Description: Glioma is the most common malignant tumor of the adult central nervous system, with high malignancy and mortality. The combination of temozolomide (TMZ) chemotherapy and radiotherapy is currently the standard first-line regimen for high-grade gliomas, but with the progress of chemotherapy, most patients will eventually develop resistance to TMZ and lead to glioma treatment failure. The results of this study provide TMZ-resistant glioma cell lines for basic and clinical research and provide potential molecular targets for reversing TMZ resistance and enhancing the effectiveness of TMZ therapy, which are of great significance for the treatment of gliomas and the improvement of patient prognosis.

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Title: Designer cell-based Biomedical tattoo for monitoring glucocorticoid levels associated with mental stress

Description: Nowadays, millions of young scientists are struggling with significant mental stress, resulting in destructive outcomes such as depression and anxiety. Here, we intend to generate a designer cell that detects blood glucocorticoids and produces a visual signal. These cells can be planted under the skin to make a biological tattoo that serves as an alarm of the potentially high-stress level. With such a tattoo, one can effectively monitor mental stress and adjust lifestyle accordingly.

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Title: Electricia Coli

Description: According to the World Health Organization, around 10 million people died of cancer globally in 2021. Cancer remains the most life-threatening disease all over the world. Therefore, early-stage cancer detection is critical for timely intervention needed to save the patient’s life.

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Title: PCBusters: Here to Save the Water

Description: Polychlorinated biphenyls (PCBs) are a carcinogen that contaminates waterways due to large-scale industrial dumping. Current methods of detecting and degrading PCBs are either environmentally harmful or expensive. We are developing safe-to-use and accessible methods of detection and degradation of PCBs based on projects from the Stockholm-2020 and Chalmers-Gottenberg-2019 teams. We are genetically engineering both Rhodococcus to enhance its natural ability to degrade PCBs and using yeast to produce bioluminescence when in the presence of PCBs. We contacted the PCB division of the EPA for advice on how we could implement our project. Additionally, we reached out to professors in Maryland who worked on developing a technique to deliver PCB-degrading microbes to contaminated bodies of water. To inform the public about our work, we collaborated with other teams to educate people through classes and social media. Our system, conscious of previous work and health concerns, can mitigate the threat of PCBs.

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Title: SynBioBot : Remote & Automated Synthetic Biology Robot

Description: Because of the pandemic situation, the entire world has been stopped. Scientists who know the solutions to overcome this problem can't go to the laboratory due to regulations. One day, Dr.Kang from Indonesia got a mail from a stranger. It was about the SynBioBot in South Korea, the Remote & Automated Synthetic Biology Robot. Through SynBioBot, he could do experiments that save the world.

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Title: R-Detox: A new beginning

Description: The Puerto Rican island municipality of Vieques was a site of military training exercises for more than 60 years. The chemicals and explosives used increased health hazards for the local population and had a detrimental effect on biodiversity. This is the reason we have chosen to continue "R-DetoX" this year. The objective of our project is to create a genetic circuit capable of biodegrading the RDX explosive, which is present in the Anones Lagoon in Vieques.

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Title: CADch me if you can!

Description: Nowdays we find ourselves in a world which is increasingly dependent on technologization. While society profits from this development in a myriad of ways, including a rise in the global standard of living, as well as a more efficient and innovative use of natural resources, we also need to be aware of the costs.

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Title: CRISPRLY

Description: Cervical Cancer is the second most common cancer in women worldwide with greater than 99% of the cases caused by human papillomaviruses (HPVs). In 2018, approximately 311,000 women died from cervical cancer and more than 85% of these deaths occurred in low- and middle-income countries. Early detection of HPVs especially the high-risk strains is essential to prevent the disease progression by tissue removal. Among the high-risk strains of the virus, HR-HPV 16 is responsible for almost 70% of cervical cancer cases. The existing methods for HPV detection, such as qPCR lack sensitivity and specificity, while FDA-approved techniques like Hybrid Capture need invasive sample collection, expensive machinery and well-trained personnel. Detection of the HR-HPVs using a simple and rapid method is extremely important to take appropriate therapeutic action against cervical cancer, particularly in areas where specialized equipment is not available. We aim to design a point of care kit for the detection of the most oncogenic strain of Human Papillomavirus i.e., HPV16 using the CRISPR Cas12a system producing a visual readout on a lateral flow assay.

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Title: PCBusters: Here to Save the Water

Description: Polychlorinated biphenyls (PCBs) are a carcinogen that contaminates waterways due to large-scale industrial dumping. Current methods of detecting and degrading PCBs are either environmentally harmful or expensive. We are developing safe-to-use and accessible methods of detection and degradation of PCBs based on projects from the Stockholm-2020 and Chalmers-Gottenberg-2019 teams. We are genetically engineering both Rhodococcus to enhance its natural ability to degrade PCBs and using yeast to produce bioluminescence when in the presence of PCBs. We contacted the PCB division of the EPA for advice on how we could implement our project. Additionally, we reached out to professors in Maryland who worked on developing a technique to deliver PCB-degrading microbes to contaminated bodies of water. To inform the public about our work, we collaborated with other teams to educate people through classes and social media. Our system, conscious of previous work and health concerns, can mitigate the threat of PCBs.

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Title: TNBCanceraser to help patients gat rid of cancer

Description: There is a well-known fact that breast cancer has overtaken lung cancer as the most frequently diagnosed cancer according to the Health China. Although almost Breast cancer have over expressing of estrogen receptor ， progesterone receptor and human epidermal growth factor receptor 2， yet other type of BC called TNBC lacks all of them . Therefore， target therapy become low response rate. Now ， the effective approach for targeting HER2 such as Trastuzumab for breast cancer still play a little role in TNBC for terrible targeting . Meanwhile ， it always associates with toxicity and resistance. Therefore， new therapy strategies to TNBC are urgently needed. Recently， Lgals2 has been proved to be a potential target for TNBC. Therefore， we decided to modify the probiotic E.colo Nissle 1917. Tsr is a typical chemoreceptor in it ， we knock its gene and use plasmid to express Tlpc which exist in H pylori. It receive stimulates and swim to the high lactic region which is characterized by cancer cell’s microenvironment. Then ， we decide to use ScFv to bind Lgals2 .After binding it ， it will induce the expression of PEA which can kill cancer cells.

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