Multiple Sclerosis (MS) is an autoimmune disorder of the Central Nervous System that has been associated with several environmental factors, such as diet and obesity.
The possible link between MS and obesity has become more interesting in recent years since the discovery of the remarkable properties of adipose tissue.
There is CONSTANT cell communication between immune cells, neural cells and fat (adipose) cells.
The more fat cells one has on the body, the more leptin, resistin, visfatin and other hormones are released. These hormones LOWER the very important cytokine called adiponectin (a neuron protector).
Also, an increase in fat cells creates an INCREASE amount of TH1 &TH17 (pro-inflammatory cytokines)n& decrease in TH2 (anti-inflammatory cytokines).
More fat cells increase nitric oxide and ROS (reactive oxygen species) that causes excess cell death.
ALL of this happening in the neural cells leads to a decrease in the re-myelination and increase of de-myelination.
This is BAD news for a disease that is listed #1 as most common demyelinating disease of the central nervous system.
📌https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5046034/