The plague continues and gets worse in the summer, with more deaths in the village. John is worried about his friend Lizzie because he has not seen her for a long time, so he visits her house. John looks through the window and discovers the plague has come to Lizzie's house as well...and that her sister is dying.

Finally the plague is over and the villagers can resume their lives. John and Lizzie are reunited and Rev Mompesson organises a bonfire for people to burn their possessions in the hope of ensuring that the plague never returns.