William Leonard Pickard is a former research associate in neurobiology at Harvard Medical School, Harvard fellow in drug policy at the Harvard Kennedy School of Government, and Deputy Director of the Drug Policy Analysis Program at UCLA. His 1996 prediction of the fentanyl epidemic was published by RAND in The Future of Fentanyl and Other Synthetic Opioids.

In 2015 Pickard published The Rose of Paracelsus: On Secrets & Sacraments, a 656-page autobiography that blends fiction and nonfiction. The book centers around six chemists in an international drug organization. One of the Six tells Pickard, the book's narrator, that the making of psychedelics is not just following a recipe or formula but requires "the requisite spirit ... the purest intent, a flawless diamond morality". He says it's the same spirit described in Thomas De Quincey and Jorge Luis Borges's short stories about Paracelsus, the 16th-century physician and alchemist of Basel who resurrected a rose from its ashes: "there could be no creation for lack of faith and the trust of gold".

Writing while incarcerated, Pickard wrote the entire book with pencil and paper. In an interview with Seth Ferranti, Pickard recounted: "The Rose was handwritten in two years, without notes and based on recollection, but seemed too trivial to honor the reader. I destroyed the work in minutes, then began again. It took another three years to compose, then a year to edit the 656 pages."

Readings of The Rose of Paracelsus were presented at the University of Greenwich in London in June 2017. Readers included British artist and Resonance FM radio host Simon Tyszko, SEED Restaurant founder Greg Sams and post-doctoral fellow in literature Neşe Devenot. In November 2016, British actor Dudley Sutton did readings of The Rose of Paracelsus at Reading Gaol, in Oscar Wilde's former cell. The Rose also has been reviewed by author and Psychedelic Museum founder Julian Vayne.

In November 2017, readings from The Rose were presented at the Altered Conference Berlin, and in December 2017 The Rose was discussed on the major podcast The Joe Rogan Experience with Duncan Trussell.