The Neanderthals are the closest extinct relatives of all present-day human and the Neanderthal genome sequence provides unique insights into modern humans origins. Svante Pääbo, a biologist and evolutionary anthropologist, describe the current understanding of the genetic contributions of Neanderthals to present-day humans and to extinct human groups. He also describes preliminary analyses of genomic features that appeared in present-day humans since their divergence from a common ancestor shared with Neanderthals and discusses how they may be functionally analyzed in the future. Pääbo is the Director of Max Planck Institute for Evolutionary Anthropology. Series: "UC Berkeley Graduate Lectures" [Science] [Show ID: 28720]