This episode reviews recent evidence on microwave and radiofrequency ablation as minimally invasive treatments for primary and secondary hyperparathyroidism, highlighting efficacy, safety, and complication profiles compared with surgery. Focusing on a multicenter prospective Radiology study in older patients, the discussion shows that both ablation techniques achieve meaningful biochemical improvement with acceptable risk, particularly as alternatives for patients who may not be ideal surgical candidates.

Efficacy and Safety of Microwave and Radiofrequency Ablationin the Treatment of Hyperparathyroidism in Older Individuals:A Multicenter Prospective Study. Zhang and Liu et al. Radiology 2025; 317(1):e243359.