In this episode of SurgOnc Today®, Dr. Julie Hallet, Chair of the SSO HPB Disease Site Working Group, reviews key updates and takeaways from the recent AHPBA Annual Meeting held in April 2024 in Miami. They are joined by Dr. Miral Grandhi, Dr. Amer Zureikat, Dr. Rebecca Snyder, and Dr. Katrina Duncan to review clinical trials on blood management for liver resection, biliary decompression for Klatskin tumors, and total venous deprivation to generate liver hypertrophy, as well as new data on genomics of pancreatic neuroendocrine tumors and bile liquid biopsy, and why evidence from clinical trials may not be adopted in HPB surgery.