Growing up in the Salinas Valley of Northern California, John Steinbeck dreamed of becoming a professional writer. In his youth he took on odd jobs and worked amongst ranch hands and migrant workers, who would inspire some of his greatest work, including The Grapes of Wrath. Published in 1939, the book captured the struggles of everyday Americans during the Great Depression, and Steinbeck became famous for his empathetic portrayal of the working class.

Steinbeck would go on to become one of the most decorated authors of the 20th Century, winning the Pulitzer Prize and the Nobel Prize for Literature, but he was plagued by marital struggles and chronic illness that threatened to cut short his writing career.

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In the late 1850s, a young man named Samuel Clemens started out piloting steamboats on the Mississippi River. Within a few years, he embarked on a writing career, adopting the pen name that became famous: Mark Twain. Armed with a wry sense of humor and a natural flair for storytelling, Twain gained wide acclaim for his short stories, travel sketches, and novels.

In 1885, he published The Adventures of Huckleberry Finn, a story of two runaways on a quest for freedom. It would become one of the most celebrated, and controversial, books in American literature. But at the height of his popularity, his risky business ventures and his critiques of American policy abroad threatened to ruin his legacy.

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In 1840, eight-year-old Louisa May Alcott moved to the small town of Concord, Massachusetts with her family. There, she spent her days wandering through the woods, putting on plays with her sisters, and learning from famed writers and philosophers such as Henry David Thoreau and Ralph Waldo Emerson.

For years, Alcott struggled to achieve success as a writer. Then in 1868, she drew inspiration from her youth to write her beloved coming-of-age novel Little Women. ​​By exploring the aspirations and challenges faced by young women, she defied 19th century norms that sought to confine women in both life and literature.

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In February 1826, 17-year-old Edgar Allan Poe was a promising student at the University of Virginia. But within a few months, gambling debts forced him to abandon his studies. It was just one of many setbacks Poe endured in a life marked by financial struggle, alcoholism, and personal tragedy.

But Poe launched a remarkable career in writing, helping to establish American literature with a bold, new voice. From short stories including “The Fall of the House of Usher,” to the poem that made him famous, “The Raven,” he transformed the horror genre by delving into the dark recesses of the human subconscious and pushing the boundaries of fiction and verse.

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In the aftermath of the St. Valentine’s Day Massacre, authorities faced mounting pressure to clean up Chicago and take down the violent mobsters who overran the city – most notoriously, Al Capone. The federal government took on the challenge, pursuing Capone relentlessly. In the end, Capone did go down – not for murder, but for tax evasion. And since Capone’s conviction in the 1930s, this unorthodox charge has been used repeatedly to bring down otherwise “ungettable” criminals. 

To discuss how the feds finally closed in on Capone, Lindsay speaks with Jonathan Eig, the Pulitzer Prize–winning author of Get Capone: The Secret Plot That Captured America’s Most Wanted Gangster.

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On Valentine’s Day 1929, seven men were gunned down in a Chicago garage in an attack that stunned the nation. Photographs of the bloody scene appeared on front pages across the country, and the public reacted with horror. Even in Chicago—a city hardened by daily gang violence—the message was clear: this was different.

City officials were under intense pressure to respond, and suspicion quickly fell on the city’s most powerful gang leader, Al Capone. But proving who ordered the hit would be far more difficult than expected. And as investigators struggled to build their case, the fallout from the massacre would change Chicago—and Capone’s fate—forever.

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In 1920, a young Al Capone arrived in Chicago looking for a fresh start, and his timing couldn’t have been better. That same year, Prohibition outlawed the manufacture and sale of alcohol, turning America’s thirst into a criminal gold rush. Chicago quickly became the epicenter of bootlegging, and Capone was determined to seize the moment and make himself rich beyond imagination. But the city was already crowded with ambitious gangsters chasing the same prize. As rival bootleggers carved up territory, Chicago descended into a violent turf war that would reshape the criminal underworld.

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In the early 1950s, Jonas Salk and Albert Sabin were in a race to develop a vaccine against polio. While Salk’s killed-virus vaccine was the first to be distributed, Sabin continued working to perfect his own approach. In the end, Sabin’s oral polio vaccine—made from a weakened live virus—proved easier to administer and was ultimately distributed far more widely, though his name never achieved the same recognition. In this episode, Lindsay is joined by epidemiologist and oral historian Karen Torghele. Her book Albert Sabin: The Life of a Polio Vaccine Pioneer is due to be published by Yale University Press in June of 2026. 

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In April 1954, a group of first graders lined up in the gymnasium of an elementary school in McLean, Virginia for the start of the Salk polio vaccine trials. In an era before widespread federal government involvement in public health, the National Institute of Infantile Paralysis executed an unprecedented experiment involving nearly 2 million children and tens of thousands of doctors, nurses, and volunteers. It was the largest peacetime mobilization in American history.

While scientists evaluated the results, Americans waited anxiously to find out whether the vaccine was safe and effective, putting an end to 40 years of fear. But in the spring of 1955, a shocking revelation would bring the vaccination program to a sudden halt.

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By the late 1940s, the National Institute of Infantile Paralysis had raised millions of dollars to pay for patient care and laboratory research. But polio cases were reaching record levels, and scientists were no closer to a cure. Frustrated by the slow progress, Basil O’Connor resolved to recruit fresh talent to the cause. He soon found what he was looking for in a young and energetic researcher named Jonas Salk.

In 1951, Salk began testing a killed virus polio vaccine on monkeys in his Pittsburgh lab. His research soon put him at odds with the leading polio scientist Albert Sabin, who wanted his own live virus vaccine formula to prevail. As their rivalry escalated, Salk prepared to take the risky step of testing his vaccine on human subjects.

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