The leaps and advances of science and technology to revolutionize human DNA have sparked fierce public debate about what the future of gene editing holds for humanity. Moving beyond some of the alarming sci-fi scenarios of gene editing, groundbreaking scientists are harnessing the power of these biological breakthroughs to save lives. At Dr. April Pyle’s laboratory at UCLA, she investigates human pluripotent stem cell biology and the differentiation of these cells for use in regenerative medicine, including therapeutic approaches for patients with muscular dystrophy. Discussing with the Los Angeles Times science and medicine editor Karen Kaplan, Dr. Pyle takes the stage to shed light on the reality of stem cell research today.

In this #1 New York Times bestseller, Michael Pollan offers a mind-bending investigation into the medical and scientific revolution taking place around psychedelic drugs—and the spellbinding story of his own life-changing psychedelic experiences as he set out to research the active ingredients in magic mushrooms. Blending science, memoir, travel writing, history, and medicine, How to Change Your Mind is a triumph of participatory journalism through Pollan’s discovery of how these remarkable substances are improving the lives not only of the mentally ill, but also of healthy people coming to grips with the challenges of everyday life. Sharing his deep dive into altered states of consciousness, Pollan discusses this unexpected new frontier in our understanding of the mind, the self, and our place in the world.

In an impassioned call to action for elites and everyday citizens alike, former New York Times columnist Anand Giridharadas shines a light on the shady side of philanthropy. Winners Take All offers a scathing investigation of how the global elite’s efforts to “change the world” preserve the status quo and obscure their role in causing the problems they later seek to solve. This bestselling groundbreaking book poses many hard questions like: Why should our gravest problems be solved by the unelected upper crust instead of the public institutions it erodes by lobbying and dodging taxes? Giridharadas shares with us some of his bold answers, including how we must take on the grueling democratic work of building more robust, egalitarian institutions to truly change the world.

Rachel Cusk is an international literary superstar. Her most recent trilogy–Outline, Transit, and Kudos–draws its hero, Faye, through a collage of vignettes. Through tales told by the people Faye encounters–an airline companion, a disgruntled neighbor, and a fellow writer, among others–Faye’s own haunting past is stealthily revealed, making for an artful and hypnotic reading experience. “After her controversial memoirs of motherhood and marriage, the writer has a new design for fiction,” writes Judith Thurman in the New Yorker in a profile titled “Rachel Cusk Gut-Renovates the Novel.” Now, the UK-based writer brings the work that has captivated the writing (and reading) community to Los Angeles for a rare Stateside reading and conversation.

On the heels of one of last year’s boldest, most celebrated novels, My Year of Rest and Relaxation, join us to hear from Ottessa Moshfegh for a celebration of a new edition of her groundbreaking debut novella, McGlue. Set in Salem, Massachusetts, 1851—the same year as the publication of Moby Dick—McGlue follows the foggy recollections of a hard-drinking seafarer who may or may not have killed his best friend. Discussing her sharply observational body of work that illuminates the exhilaratingly dark psychologies of wayward characters, Moshfegh will share the stage with Amanda Stern, the author of Little Panic, a fiercely funny new memoir on anxiety.

As the Executive Director of the Committee to Protect Journalists, Joel Simon spends his time taking action on behalf of journalists who are targeted, attacked, imprisoned, or killed. He is an expert on how countries around the world handle the kidnapping of their nationals, including how they analyze and respond to intelligence and provide support for the hostage families. At a time when journalists are in greater danger than ever before, Simon’s newest book draws on his extensive experience interviewing former hostages, their families, employers, and policy makers to lay out a new approach to hostage negotiation. He is joined onstage by Sewell Chan, deputy managing editor at the Los Angeles Times, as well as Federico Motka, an Italian aid worker who spent a year as a hostage of Isis in Syria.

What might Marilyn Monroe, Cesar Chavez, Susan Sontag, and Albert Einstein have to say about Los Angeles? Their diary entries, along with those of other actors, musicians, activists, cartographers, students, geologists, cooks, merchants, journalists, politicians, composers, and many more—provide a kaleidoscopic view of Los Angeles over the past four centuries from the Spanish missionary expeditions of the 16 century to the present day. Book editor, critic, and Los Angeles native David Kipen has scoured the archives of libraries, historical societies, and private estates to assemble a remarkably eclectic story of life in his beloved Los Angeles. Join us for a special staged reading of these first-person accounts—representing a range of experiences and voices as diverse as Los Angeles itself.

Bestselling author Reyna Grande’s newest memoir, A Dream Called Home , offers an inspiring account of one woman’s quest to find her place in America as a first-generation Latina university student and then pursue her dream of writing. Award-winning writer Jean Guerrero’s Crux: A Cross-Border Memoir tries to locate the border between truth and fantasy as she explores her troubled father’s life as an immigrant battling with self-destructive behavior. Octavio Solis, one of the most prominent Latino playwrights in America, turns to nonfiction in Retablos: Stories From a Life Lived Along the Border, a new collection of stories about growing up brown at the U.S./Mexico border. At this most urgent time of family separation through borders, join us for a unique evening of storytelling as we welcome these three fierce voices to share from their work that breaks down the walls of the immigrant experience.

Bestselling author Reyna Grande’s newest memoir, A Dream Called Home, offers an inspiring account of one woman’s quest to find her place in America as a first-generation Latina university student and then pursue her dream of writing. Award-winning writer Jean Guerrero’s Crux: A Cross-Border Memoir tries to locate the border between truth and fantasy as she explores her troubled father’s life as an immigrant battling with self-destructive behavior. Octavio Solis, one of the most prominent Latino playwrights in America, turns to nonfiction in Retablos: Stories From a Life Lived Along the Border, a new collection of stories about growing up brown at the U.S./Mexico border. At this most urgent time of family separation through borders, join us for a unique evening of storytelling as we welcome these three fierce voices to share from their work that breaks down the walls of the immigrant experience. 

In the award-winning short story writer’s much-anticipated first book in over 12 years, Deborah Eisenberg brings the same signature brilliance of her past work that has made her one of the great American masters of short fiction. Both raucously hilarious and solemnly mysterious, Eisenberg’s new collection, Your Duck is My Duck, confronts the most disturbing truths about ourselves—from our intimate lives as lovers, parents, and children, to our equally troubling roles as citizens on a violent, terrifying planet. With her uncanny ability to conjure the strange states of mind and emotion that constitute our daily consciousness, Eisenberg embodies the indifferent but beautiful universe around us. Critic and journalist Laurie Winer will dive into these delightfully unsettling worlds with Eisenberg for a conversation about this new collection, along with a reading of Eisenberg’s work by a special guest.