In this episode of AIDS 2020, Steve and Andrew speak with Ambassador Deborah Birx, U.S. Global AIDS Coordinator and Special Representative for Global Health Diplomacy. Ambassador Birx has been on the front lines of the HIV/AIDS response both in the U.S. and around the world since the earliest days of the epidemic, and has led PEPFAR (the President’s Emergency Plan for AIDS Relief) for six years. She previously served as Director of Centers for Disease Control and Prevention's Division of Global HIV/AIDS, and as the Director of the U.S. Military HIV Research Program at the Walter Reed Army Institute of Research. They discuss the work PEPFAR is doing to prioritize the health and education of young women, the need for stronger evidence and accountability in HIV programming, and making the impossible possible with diplomacy and partnerships.