Have you seen "A.P. Bio?" It's one of the funniest network sitcoms out these days and its latest second season is going strong on NBC. The show tells the story of a disgraced Harvard Philosophy professor (played by Glenn Howerton of "It's Always Sunny in Philadelphia") who finds himself teaching Advanced Placement Biology at a high school in his hometown of Toledo, Ohio. Mike O'Brien created the show, and he joins Jesse to talk about the show's new season. Plus: his own childhood in Toledo, and explains some of the baffling questions the writers room had about his hometown. Like, truly baffling.

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