JACI: In Practice Editor Michael Schatz describes the April issue, the theme of which is “Newer Approaches to Asthma Management”. Theme topics covered include phenotyping severe asthma in the current era of biologics, management of extrapulmonary treatable traits, downstream impacts of systemic inflammation in patients with asthma, the relationship to asthma and therapeutic potential of alterations in the respiratory and gut microbiome, the new paradigm of inhaled corticosteroid use as part of reliever therapy, and the recently articulated goal of achieving disease remission. Dr. Schatz then presents the Highlights of the Original Articles in the issue, which are on the topics of Asthma, Drug Allergy, Eosinophilic disorders, Food Allergy, Hereditary Angioedema, Immunodeficiency, and Rhinosinusitis.