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Dr. Mia talks with her colleague Dr. Tim Hughes, about vascular and metabolic conditions' contribution to Alzheimer's disease and related dementias.

Timothy Hughes, PhD, is an Associate Professor in the Department of Internal Medicine at Wake Forest School of Medicine. He is a neuroepidemiologist cross-trained in cardiovascular epidemiology and multimodal brain imaging. His research focuses on untangling the complex relationships between vascular and metabolic diseases' contributions on dementia.

Lancet commission report - https://www.thelancet.com/article/S0140-6736(20)30367-6/fulltext

Summary of SPRINT MIND: https://www.nia.nih.gov/news/does-intensive-blood-pressure-control-reduce-dementia

MESA participant webpage: https://www.mesa-nhlbi.org/ParticipantWebsite/default.aspx

Alz Association’s Trial Match: https://www.alz.org/alzheimers-dementia/research_progress/clinical-trials/trialmatch

Research Match https://www.researchmatch.org/

If people want to participate in ACE study:  [email protected];  and https://www.acetrial.org/

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Dr. Mia talks with Caroline Prioleau, writer for the Global Brain Health Institute at University of California San Francisco's Memory & Aging Center and co-lead of the Hear/Say oral history project that collects stories from people's experiences with dementia, aging, creativity and caregiving. We talked about a new documentary called Keys Bags Names Words - about hope in dementia.

Sign up for a virtual or in-person screening here. 

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Dr. Mia talks with Dr. Ashley Sanderlin about how to advocate for yourself or your love ones within the healthcare system.

Ashley H. Sanderlin, PhD is a passionate researcher that investigates modifiable risk factors and early interventions for Alzheimer’s disease. She was the first African American to attain a PhD in Neuroscience from Michigan State University. As an Assistant Professor in Biology at NC A&T State University, Dr. Sanderlin serves as the site Principal Investigator of the North Carolina Brain Health Registry and lead faculty in the Center for Outreach in Alzheimer’s Aging and Community Health (COAACH), which is the nation’s most prominent outreach and education centers focused primarily on the impact of Alzheimer’s on African Americans and their caregivers.

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Dr. Mia talks about the other main reason why people end up in nursing homes- "legs not working" aka falls, especially the factors that affect people's balance and what to do about each of the risk factors.

New format of episode with screen share, check out Dr. Mia's new YouTube Channel if you would prefer to follow along visually.

Medications that increase risk of falls
CDC's STEADI program on fall prevention
STEADI program's brochures specifically for patients & caregivers: home safety check list and chair rise exercise
MyMobility plan: plan ahead for mobility changes as we age

How to use Apple Podcast app to subscribe on iPhone- tutorial video
Or subscribe via email on my website: scroll down, on right side.  

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In this episode of Ask Dr. Mia podcast, Dr. Mia talks to her colleague, neuropsychologist and memory researcher Dr. Bonnie Sachs. 

Dr. Bonnie Sachs is a board-certified clinical neuropsychologist who specializes in working with older adults with memory loss and other cognitive disorders. Her areas of focus, both clinically and in research, include mild cognitive impairment (MCI), Alzheimer's disease (AD), and other forms of neurodegenerative diseases like Parkinson's disease, Frontotemporal dementia, Vascular dementia, and Lewy Body dementia. Dr. Sachs is an Associate Professor in the Departments of Neurology and Internal Medicine, Section of Gerontology & Geriatric Medicine, and is also an Investigator with the Wake Forest Alzheimer's Disease Research Center (ADRC). Additionally, Dr. Sachs enjoys education training and she currently co-directs the Clinical Neuropsychology Fellowship Program at the Wake Forest School of Medicine.

Dr. Sachs talks about how she became interested in the field, the training for neuropsychologists, what they do, and when patients should see a neuropsychologist. 

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Returning back to Season 3 of Ask Dr. Mia Podcast talking about what is Comprehensive Dementia Care and Medicare's new program to pay for it.

Health Affairs' article on Comprehensive Dementia Care: https://www.healthaffairs.org/content/forefront/payment-comprehensive-dementia-care-five-key-recommendations

Medicare's GUIDE program: Guiding an Improved Dementia Experience:  https://innovation.cms.gov/innovation-models/guide

D-CARE Study: https://www.dcare-study.org/

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For the last episode of season 2, Dr. Mia talks about lecanemab, a monoclonal antibody against amyloid, results since the show's most popular episode on lecanemab released on 10/7/2022.

Lecanemab or Clarity AD clinical trial results in New England Journal of Medicine (NEJM)
Death related to lecanemab, reported in Science, related to Cerebral Amyloid Angiopathy
Donanemab press release by Lilly

Key points:
1) Aducanumab approval process eroded public's trust and careful screening for patients for real-world implementation of lecanemab is needed to build back trust.
2) Actual number of patients eligible for lecanemab will be much smaller than the total number of persons living with Alzheimer's disease in the country: studies estimate anywhere from 1% to 12% of patients seen in real world clinics.  
3) Our healthcare infrastructure is not ready for early, timely, and accurate detection of Alzheimer's disease and tracking patients on monoclonal antibodies. 

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In this episode, Dr. Mia talks with Dr. Trey Bateman about Lewy Body dementia, unique challenges in diagnosis, different treatment options compared to Alzheimer's dementia, and his research on Mild Behavioral Impairment.

Dr. James (Trey) Bateman is a behavioral neurologist at Wake Forest University School of Medicine and the Salisbury Veterans Affairs Medical Center. His clinical care is spread across both Wake Forest and the Salisbury VA, where he focuses on the evaluation and care of people with neurodegenerative conditions, especially those with prominent neuropsychiatric symptoms. His research is focused on the role of chronic psychosocial stress and dementia risk and the role of early neuropsychiatric symptoms in the prodromal stages of neurodegenerative cognitive disorders.

More information on Dementia with Lewy Bodies

Anticholinergic medications based on the 2023 American Geriatrics Society Beers list of medications to use with caution in older adults

Support groups specifically for caregivers and persons living with Lewy Body Dementia

 

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With the recent news of Bruce Willis' diagnosis of frontotemporal dementia, I talk with Dr. Halima Amjad about her own personal journey with her late father's FTD diagnosis as well as her professional role in dementia care and research.

Dr. Halima Amjad is an assistant professor of medicine at the Johns Hopkins University School of Medicine. Her career as a geriatrician and health services researcher centers around people living with dementia. She cares for patients at the Johns Hopkins Memory and Alzheimer’s Treatment Center. Her research focuses on medical care challenges in dementia, including underdiagnosis, hospitalization, and primary care support. Her advocacy work includes serving on the Board of the Association for Frontotemporal Degeneration and as chair of the Maryland Virginia I. Jones Alzheimer’s disease and related dementias council.

The Association for Frontotemporal Degeneration

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Sleep, everyone wants it or better versions of it. Dr. Mia talks with Dr. Jaime Hughes about sleep for older adults.
Jaime Hughes is an Assistant Professor at Wake Forest University School of Medicine, Department of Implementation Science and Section on Gerontology and Geriatric Medicine. As an implementation scientist, Dr. Hughes focuses on how to spread programs that work into different settings, including healthcare clinics and community-based services. She has a particular interest in programs to help older adults sleep well and move more. Her work is supported by a team of public health and clinical researchers who comprise the AMAZE Research Team – Atrium Health Wake Forest Baptist Movement And Zzz’s for Everyone. Dr. Hughes received her PhD from UNC at Chapel Hill and her MPH and MSW from University of Michigan.

Interested in learning more about research opportunities in sleep and aging? Email Dr. Hughes' team at [email protected]. 

 Other resources:

Sleep and Aging

Healthy Sleep Habits

Cognitive Behavioral Therapy for Insomnia

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Video on Ask Dr. Mia YouTube channel
Transcripts on www.miayangmd.com. Transcripts are automatically generated and may contain minor inaccuracies. 
Email: [email protected]
Opinions expressed are exclusive of Dr. Mia Yang and not reflective of her or guest speaker's employers or funders.