Listen as Deputy Editor Merry Lindsey (University of Nebraska Medical Center) interviews authors Leslie Ogilvie and Jeremy Simpson (University of Guelph) and expert Michael Czubryt (University of Manitoba) about the recent Review by Ogilvie et al. on the importance of evaluating best practices in the hemodynamic assessment of diastolic function for animal models. With significant clinical focus on the role diastolic dysfunction plays in heart failure with preserved ejection fraction (HFpEF), cardiac fibrosis, and diabetes, there is no better time to examine diastolic functional assessments in experimental models. “Diastolic function has emerged as being equally important to systolic function in the overall ability of the heart to function as a pump,” explains Simpson. We discuss rodent models of human diastolic dysfunction in the setting of HFpEF, and understanding diastolic function in terms of its two phases—relaxation and filling. What recommendations do Ogilvie and Simpson make for handling the inherent limitations of software-based algorithms? Listen and learn more.

 

Leslie M. Ogilvie, Brittany A. Edgett, Jason S. Huber, Mathew J. Platt, Hermann J. Eberl, Sohrab Lutchmedial, Keith R. Brunt, Jeremy A. Simpson Hemodynamic assessment of diastolic function for experimental models Am J Physiol Heart Circ Physiol, published April 21, 2020. DOI: doi.org/10.1152/ ajpheart.00705.2019