President of the United States Ronald Reagan was shot and wounded by John Hinckley Jr. in Washington, D.C. as he was returning to his limousine after a speaking engagement at the Washington Hilton. Hinckley believed the attack would impress actress Jodie Foster, with whom he had developed an erotomanic obsession.

Reagan was seriously wounded by a .22 Long Rifle bullet that ricocheted off the side of the presidential limousine and hit him in the left underarm, breaking a rib, puncturing a lung, and causing serious internal bleeding. He was close to death upon arrival at George Washington University Hospital but was stabilized in the emergency room, then underwent emergency exploratory surgery. He recovered and was released from the hospital on April 11. No formal invocation of sections #3 or #4 of the Constitution's 25th amendment (concerning the vice president assuming the president's powers and duties) took place, though Secretary of State Alexander Haig stated that he was "in control here" at the White House until Vice President George H. W. Bush returned to Washington from Fort Worth, Texas.

White House press secretary James Brady, Secret Service agent Tim McCarthy, and DC police officer Thomas Delahanty were also wounded. All three survived, but Brady had brain damage and was permanently disabled. His death in 2014 was considered a homicide because it was ultimately caused by his injury.