Where does Adderall come from?
The decongestant properties of amphetamine were discovered by accident in the 1920s. In 1927, a Romanian chemist named Lazăr Edeleanu synthesized amphetamine for the first time, but he did not recognize its stimulant properties. Instead, he used it to create a nasal decongestant called Benzedrine.
Edeleanu was looking for a synthetic substitute for ephedrine, a natural decongestant derived from the ephedra plant, which was in short supply then. He synthesized amphetamine by reacting phenylacetone with ammonia and reducing the resulting product with zinc and hydrochloric acid.
During the 1930s and 1940s, amphetamines were prescribed by doctors and became a popular ingredient in many over-the-counter remedies. The military began using amphetamines to keep soldiers vigilant and diminish combat fatigue during World War II.
It seems the only reason we have focus drugs like Ritalin, Adderall, and Vyvanse (at all) is partly because of the availability of natural ingredients used to make stimulants in the past and how difficult it was to maintain and distribute naturally derived ingredients with finite lifespans and supplies. That's why it is odd to me that the problem of scarcity we aimed to eliminate in the first place has returned after creating synthetic alternatives that work even better.
How come there's a shortage of Adderall in 2023?
The answer is confusing.
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