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Authentic Biochemistry
Authentic Biochemistry episodes
- ImmunoEpigenetics 68. Closure on atherosclerosis and CVD linking transcription factors and membrane receptors to oxidation of PUFA's and oxysterol resulting in methylation of ABCG and SREB promoters
References
Arterioscler Thromb Vasc Biol . 2021 Jan;41(1):153-166.
Clinical Epigenetics 2021. volume 13, Article number: 7.
https://www.sciencedirect.com/topics/immunology-and-microbiology/foam-cell
30 min - ImmunoEpigenetics 67. Pathobiochemical alteration of cholesterol oxides mediated via cytochrome P450 and dehydro -reductases link atherosclerosis and the CTX/SLO motor neuron diseases. DJGPhD
References
JLR 2014 55(6) Pages 1165-1172.
JLR 2018 59(6): 1058–1070.
30 min - ImmunoEpigenetics 66. The NOX/PHOX/DUOX enzymes in atherosclerosis, thyroid hormonogenesis and thyroid tumorigenesis. An epigenetic telos from oxidized lipid to altered transcription patterns.DJGPhD.
References
PLoS ONE 2012. 7(4): e3440Steroids 2021. Volume 172, August, 108854
Antioxidants 2019, 8(5), 126
30 min - ImmunoEpigenetics65. 7-keto-cholesterol-induced miR-144 transcription inhibits IDH2 translation lowering NADPH required for NO synthesis to maintain endothelial function leading to atherosclerosis.
References
Free Radical Biology and Medicine
Volume 71, June. Pages 1-15Cardiovasc.Res. 2012 May 1; 94(2): 379–390.Int. J. Mol. Sci. 2020, 21(7), 2578; https://doi.org/10.3390/ijms21072578
30 min - ImmunoEpigenetics65A. Micro-RNA mediated cancellation of mitochondrial NADPH-producing Isocitrate Dehydrogenase 2is controlled by 7-Keto cholesterol. DJGPhD 12May2023. Authentic Biochemistry Podcast
References
Free Radical Biology and Medicine
Volume 71, Pages 1-15Steroids. 2021 Aug; 172:108854.---Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/messageSupport this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support16 min - ImmunoEpigenetics64. IDH1/2 ad Malic enzymes 1/2/3 may generate NADPH thus driving removal of ROS while simultaneously promoting atherosclerosis and tumorigenesis via epigenetic and bioenergetic means
References
Free Radical Biology and Medicine 2014. Volume 71, June.Pages 1-15
J Mol Endocrinol. 2020 Nov; 65(4): R77–R90.
REDOX and Cholesterol metabolism lectures-Dr Guerra
30 min - ImmunoEpigenetics63. Amino acid metabolism is linked to DNA methylation via glycolytic intermediates and redox poise to expose neomorphic /antimorphic IDH1/2 transformation generating oncometabolites
References
Cancers (Basel). 2019 May; 11(5): 678.
Oncogene.2017 Mar 23; 36(12): 1607–1618
Dr Guerra's annotated lecture notes from graduate biochemistry course(s)
30 min - ImmunoEpigenetics62.Macrophage "training" and T cell activation are epigentically controlled by moonlighting glycolytic and amino acid metabolic enzymes generating enantiomers of 2-OH glutarate.DJGPhD
References
Front. Cell Dev. Biol., 26 March2021 Sec. Molecular and Cellular Oncology Volume 9
Cancer Drug Resist 2020;3:762-74.
Oncogene.2017 Mar 23; 36(12): 1607–1618
Front Immunol. 2020; 11: 1782.
30 min - ImmunoEpigenetics61. The role of leucocyte and lymphocyte aerobic glycolysis and bioenergetic trafficking between cytosol and the mitochondria mediating nuclear epigenetic substrate availability.
References
Dr Guerra Intermediary metabolic lecture notes-graduate biochemistry lecture archives
Epigenetics. 2019; 14(12): 1183–1193.
Drug Discov Today. 2017 Jan; 22(1): 186–193.
30 min - Immunoepigenetics 60. LOH of PHLDA3 confers wt allelic methylation and loss of activity in pancreatic neuroendocrine tumorigenesis. DJGPhD.7May23 Authentic Biochemistry Podcast
References
Int J Mol Sci. 2020 Jun; 21(11): 4098.
30 min
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You have wisely landed upon Authentic Biochemistry, with Dr. Daniel J Guerra, where published biochemical, physiological, genetic and immunological research along with biomedical and pharmaceutical science are interrogated.