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Authentic Biochemistry
Authentic Biochemistry episodes
- ImmunoEpigenetics 50. Malic Enzyme serves as a cytosolic circuit to generate pyruvate from glutamine to drive cancer cell division by altering TCA flux and indirectly, cell cycle progression.DJGPhD
References
Cell 2012 148DOI: (10.1016/j.cell.2012.01.031)
Biotechnology Journal 2016. Volume11, Issue1 Special Issue: Biotech Methods and Advances: 71-79.
Molecular Cancer. 2020. volume 19, Article number: 39.
30 min - ImmunoEpigenetics49.SiRNA knockdown of ME1 increases Haeme Oxygenase activity in both glucose supplemented and deprived cancer cells. The Pseudoparadox of epigenetic control over metabolism. DJGPhD
References
Dr Guerra's lectures and spontaneous expectorations.
Molecular Cancer 2020. volume 19, Article number: 39
30 min - ImmunoEpigenetics48. Importance of malic enzyme isoform subcellular distribution using 13CNMR -U13C C6 glucose isotopomer detection of pathway intermediates:GSIS vs. cancer.DJGPhD.21.3.23
References
Methods Enzymol. 2009; 457: 425–450
Endocrinology, Volume 155, Issue 5, 1 May 2014, Pages 1653–1666
Am J Physiol Endocrinol Metab. 2008 Dec; 295(6): E1287–E1297
30 min - Immunoepigenetics 47. Intermediary metabolism re-enters the discussion on tumor corruption of cell division via diversion of glucose to NADPH production.DJGPhD
References
Dr Guerra's lectures
AJP Endocrinology and Metabolism. 2008. 295(6):E1287-97
Biochem Biophys Res Commun.1996 May 15;222(2):287-91
Carcinogenesis.2020 Jun; 41(4): 405–416
Oncogenesis 2017. volume 6, page e329.
30 min - ImmunoEpigenetics 46.The Keap1/Nrf2/MAF axis in colorectal cancer: Methylation specific promoter mediated expression of anti-oxidant genes unveiling a complex role in tumorigenesis.DJGPhD.15.3.23
References
Carcinogenesis. 2020 Jun; 41(4): 405–416
Rep Biochem Mol Biol. 2020 Apr; 9(1): 33–39
30 min - ImmunoEpigenetics 45. Innate immune cell nSMASE generates ceramide mediated TLR signalling epigenetic alterations resulting in COX-2 electrophile PG- Michael adduct removal of KEAP/Nrf2 association.
References
Carcinogenesis. 2020 Jun; 41(4): 405–416
Rep Biochem Mol Biol. 2020 Apr; 9(1): 33–39
30 min - ImmunoEpigenetics 44. Ceramide and NRF2 mediate oxygen stress and the pro-inflammatory cytokine respose via association with chromatin epigenetic retailoring. DJGPhD.8March23. Authentic Biochemistry.
References
Antioxidants (Basel). 2023 Feb; 12(2): 274
J Lipid Res. 2016 May; 57(5): 868–881.
J Biol Chem. 2007 Jan 12;282(2):1384-96.
J. Am. Chem. Soc. 2014, 136, 36, 12624–12630
30 min - ImmunoEpigenetics XXXXIII. In silico analysis of Rheumatoid Arthritis methylation patterns fails to obtain a general rule for epigenetic regulation of gene expression.DJGPhD07March23. ABPe
References
Int J Hematol 2022. 116, 828–836
Cancer Immunol Res (2022) 10 (1): 87–107
Front Immunol. 2022; 13: 881191
Nature Reviews Immunology 2018. volume 18, pages 617–634.
30 min - ImmunoEpigenetics XXXXII. T-ALL Homeobox A gene alteration of MEF2C expressional variation linked to T-cell differentiation blockade as regulated by CaMK and HDAC4/HDAC5. DJGPhD. 05March23.
References
Biochem J 2012 444(1):105-114
Epigenetics. 2015 May; 10(5): 418–430.
Nature Reviews Immunology volume 2018. 18, pages 617–634
29 min - ImmunoEpigenetics XXXXI. From Programmed Cell Death to Homeobox gene clusters, T-ALL leukaemias involve epigenetic events. DJGPhD.05March23. Authentic Biochemistry Podcast
References
Genes & Diseases Available online 26 December 2022
Int J Mol Sci. 2021 May; 22(10): 5317
Haematologia 2016. Vol. 101 No. 6 June.
Blood (2005) 106 (1): 274–286
Nature Reviews Immunology 2018. volume 18, pages 617–634.
30 min
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You have wisely landed upon Authentic Biochemistry, with Dr. Daniel J Guerra, where published biochemical, physiological, genetic and immunological research along with biomedical and pharmaceutical science are interrogated.