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Authentic Biochemistry
Authentic Biochemistry episodes
- A Dialectic on Research Scientific Method I. How research questions may be apprehended through the hypothetico-deductive-experimental paradigm. DJGPhD. 14.2.23
References
Guerra: lectures on research methods
30 min - ImmunoEpigenetics XXVIII, Synthesis of epigenetically controlled ferroptosis with Cyto-Toxic T Lymphocyte APC/MHC activated IFN-Gamma induced tumor fatty acyl CoA synthase- lipid peroxide mechanism.
References
Cancer Cell 2020. 40, Issue 4, Pages 365-378.e6
Circulation Research. . 2004 May 28;94(10):1318-24.
Mol Cell. 2020 Jun 18;78(6):1192-1206.e10
Cell. 2012 Aug 17;150(4):685-96
Cell Death Differ. 2020 May; 27(5): 1660–1676.
30 min - Immunoepigenetics XXVII. PKM2 as an epigenetic and metabolic author of cell proliferation leading to tumorigenesis. DJGPhD. 12 Feb 2023. Authentic Biochemistry Podcast
References
Mol Cell. 2014 Mar 6;53(5):700-9
Mol Cell. 2015 Sep 3;59(5):850-7
Cell & Bioscience 2019.Volume 9, Article number: 52.
30 min - ImmunoEpigenetics XXVI.The repressive deubiquitinase (PR-DUB) inhibits ubiquitinated histone 2A occupancy on SLC7A11 promoter causing cystine starvation and GSH depletion promoting ferroptosis. DJGPhD
References
Cell Research. 2022. volume 32, pages 687–690 .
30 min - ImmunoEpigenetics XXV. Lymphocyte Specific Helicase inhibits ferroptosis while promoting tumorigenesis via fatty acid desaturase gene transcription and subsequent oleic acid formation via CoQ10.DJGPhD
References
Molecular Cancer 2020. volume 19, Article number: 39.
Adv Exp Med Biol. 2021; 1301:41-57
30 min - A Biochemical Partita 7th Movement. The articulation of obesity as arbiter of pathophysiology. DJGPhD. 04Feb23. Authentic Biochemistry.
References and Inspiration
Dr Guerra lecture notes
https://youtu.be/uubKzLxxj1s
30 min - A Biochemical Partita 6th Movement. Human bioenergetics and hormonal regulation involving FA beta-oxidation and gluconeogenesis "discourage" glyoxylate cycle molecular evolution a priori. DJGPhD.
References and Inspirations
Dr Guerra graduate biochemistry lectures
https://youtu.be/156u4nV2uGE
30 min - A Biochemical Partita 5th Movement. The hepatic Malate Apartate Shuttle combined with the 2-oxoglutarate carrier facilitate reducing power and the OAA carbon source for cytosolic gluconeogenesis.
References and Inspirations
Dr Guerra's lecture notes-graduate biochemistry
https://youtu.be/nP4nBxMtEug
30 min - A Biochemical Partita 4th Movement.Regulation of gluconeogenesis vs. glycolysis and the fatty acyl CoA beta-oxidation pathway provide REDOX and allosteric control over bioenergetics. DJGPhD.01FEB23.
References&Inspirations
Guerra intermediary metabolic lectures
https://youtu.be/nDidA8_gfbU
30 min - ImmunoepigeneticsXXIV. The Cathelicidin anitmicrobial peptide cysteine protease domain may contibute to innate immune defense against cancer via epigenetically regulated ferroptosis.DJGPhD.1Feb23
References
Peptides . 2020 Jan;123:170177
Molecular Cancer. 2020. volume 19, Article number: 39.
30 min
About Authentic Biochemistry
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You have wisely landed upon Authentic Biochemistry, with Dr. Daniel J Guerra, where published biochemical, physiological, genetic and immunological research along with biomedical and pharmaceutical science are interrogated.