For today's episode, we go into the science of embryogenesis, focusing on neurulation—the critical process where the neural tube forms, laying the groundwork for the central, peripheral, and enteric nervous systems. We discuss how disruptions in this early developmental stage, influenced by factors like folic acid metabolism, the sonic hedgehog pathway, and genes such as PTEN (P10), could shape the autistic phenotype. From cell proliferation to migration, we connect these biological processes to autism, exploring how environmental factors—like a pregnant mother’s exposure to artificial light versus sunlight—might alter developmental outcomes. This episode sets the stage for when the Autistic phenotype begins and for more detail on why the mesencephalon does not evolve into other cell types like the other three areas (prosencephalon, rhombencephalon, and spinal cord).

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0:00 Daylight Computer Company

4:20 Neurulation; primary & secondary

6:26 Neural tube, MTHFR & Folate (Vitamin B9), DNA methylation

11:51 Neuroepithelial Cells; Neural Crest, Surface Ectoderm, Mesodermal

16:05 Environmental implications, proliferation, differentiation, and migration

18:45 PTEN

26:29 Modern Environments

28:00 What do you think light is? Autism is in the Womb

31:40 Hyper and Hypo-connectivity

34:40 some rants

35:51 Leo Kanner kid, Donald Tripplet; The Biology that gives us Autism allows us to be comfortable within ourselves; more rants, probably

37:59 Review/Ratings & Contact Info

X: https://x.com/rps47586

Hopp: https://www.hopp.bio/fromthespectrum

YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuA

email: [email protected]