Neurology specialist Dr. Michael Mega joins Suzanne courtesy of Athira Pharma to discuss the root causes of Alzheimer's disease. Dr. Mega is the Director of the Center for Cognitive Health in Portland, OR. He has published multiple scientific papers, book chapters, and a textbook contributing to the field of cognitive neuroscience.

"And so how do we say disease has changed its definition from probable during life, to now definitive, by measuring the amount of plaque tangles in the living brain of our patients. So getting to those plaques and tangles can be caused by many different paths. One, you could have an autosomal dominant inherited disorder that runs in your family with 50% of the family affected. Those tend to be very rare, but that's one way to get to plaque and tangle disease or Alzheimer's disease. Other way is the foods we eat, the lifestyle we pursue, our cognitive stimulation. So all of us make these misfolded amyloid proteins, that are at first soluble, before they precipitate into the brain as plaque, but those of us that get to the disease either makes too much of them or they don't clear them properly, and they're cleared during REM sleep. So, sleep disorders are associated also with not only Parkinson's disease, Lewie body disease, but also with not clearing amyloid properly. So sleep abnormalities, not eating a healthy Mediterranean style diet, being under stress at work or at home, not having cognitive stimulation that keeps your brain active during aging, having diabetes, having heart disease. There's many different roads to get to Alzheimer's. What is the real cause? Well, it's multifactorial, which has been the reason, the main reason, why it's so hard to treat this disorder."

He emphasizes that there are many ways of developing Alzheimer's disease. Developing medications may be able to remove the amyloid beta proteins and prevent this sort of cognitive decline. We're getting closer to proving the hypothesis that amyloids are the cause of Alzheimer's. He feels that upcoming medications may be used in the future more for prevention instead of treatment.

Visit the Center for Cognitive Health to learn more, see details on cutting edge research, and a list of active clinical trials at their clinic. You can also call (503) 476-9788. Hear more Alzheimer's-related podcasts from Athira Pharma, as well as other shows with Dr. Michael Mega. Visit lift-adtrial.com to learn about Athira Pharma's LIFT-AD Alzheimer's Disease trial. 

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