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Part 1 of 4: Jon Chee hosts Barry Ticho, Founder of Verve Therapeutics and Chief Medical Officer at Stoke Therapeutics, a biotech company addressing the underlying cause of severe diseases by upregulating protein expression with RNA-based medicines.
With an MD-PhD from the University of Chicago and extensive experience across academia and industry, Barry brings over two decades of expertise in clinical development. His journey includes roles as Head of Development at Moderna, Head of External R&D Innovation at Pfizer, and VP of Clinical Development at Biogen, where he's been instrumental in advancing numerous therapeutic programs across multiple disease areas.
Barry's unique perspective spanning academic medicine and biotechnology innovation makes his insights invaluable for aspiring leaders in the field.
Join us this week to hear about:- Barry's upbringing as one of five boys in a family of physicians
- A transformative moment watching a child regain sight that crystallized his career path
- His foundational experiences at Haverford College where he discovered his passion for biology
- His journey through the MD-PhD program at the University of Chicago
- How education, critical thinking, and resilience shaped his leadership approach
Please enjoy Jon’s conversation with Barry Ticho.
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Find Our Guest, Barry Ticho at these links:Â https://www.linkedin.com/in/barryticho/Â https://www.stoketherapeutics.com/Â https://www.vervetherapeutics.com/Â
Find Our Host, Jon Chee, at these links:Â https://www.linkedin.com/in/joncheehttps://www.excedr.com
Excedr Socials & WebsiteLinkedIn: https://www.linkedin.com/company/excedr/ Youtube: https://www.youtube.com/@excedr Instagram: https://www.instagram.com/excedr_inc Twitter: https://twitter.com/ExcedrInc Facebook: https://www.facebook.com/excedr TikTok: https://www.tiktok.com/@excedr Podcast Website: https://www.thebiotechstartupspodcast.com/
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Enriched Notes:
Topics Mentioned:Stoke Therapeutics https://www.stoketherapeutics.com/ Verve Therapeutics https://www.vervetherapeutics.com/ Moderna https://www.modernatx.com/ Pfizer https://www.pfizer.com/ Biogen https://www.biogen.com/ Ophthalmology https://en.wikipedia.org/wiki/Ophthalmology Haverford University https://www.haverford.edu/ University of Chicago https://www.uchicago.edu/en Harvard Medical School https://hms.harvard.edu/ Boston Children's Hospital https://www.childrenshospital.org/Â
How to Spin Out of Academia: https://www.excedr.com/resources/how-to-spin-out-of-academia-and-into-a-startupPatent Licensing for Biotechs: https://www.excedr.com/resources/how-patent-licensing-worksBiotech Startup Support: https://www.excedr.com/resources-category/biotech-startup-support
People Mentioned:Phil Sharp https://en.wikipedia.org/wiki/Phillip_Allen_Sharp Murray Rabinowitz https://www.nasonline.org/wp-content/uploads/2024/06/rabinowitz-murray.pdfÂ
Timestamps:00:00 Intro03:04 Barry's background and introduction03:37 Growing up in a family of Holocaust survivor physicians05:29 Four out of five brothers choosing medicine07:14 Early exposure to ophthalmology and patient care09:27 The transformative moment: witnessing a child regain sight12:45 Choosing Haverford and discovering biology14:06 Early laboratory experiences and liberal arts education19:05 The path to University of Chicago's MD-PhD program22:13 First research experiences with RNA and transcription23:55 Graduate school years: freedom and scientific method30:15 Mentorship style and thesis advisor's influence33:05 Leadership lessons from graduate training36:28 OutroThe Biotech Startups Podcast gives you a front-row seat to the business
and science of building a biotech. Hosted by Jon Chee, CEO of Excedr, the show features honest conversations with founders, execs, and investors about their work, their companies, and how they got there. From scientific breakthroughs to startup lessons, each episode explores what it really takes to grow a life science company—from pre-seed to IPO.