Base by Base - Music

This release contains only the music track from Base by Base Episode 299.

Song title: Folded Signals
Original Base by Base episode: 299: UFM1 loss and R81C mutation disrupt neuronal translation, ER stress, and synaptogenesis
Original episode link: https://basebybase.com/episodes/ufm1-r81c-neuronal-translation

Article metadata:
Article title: Encephalopathy-linked UFM1 variants impede neuronal protein translation, development, and function
Journal: EMBO Molecular Medicine, doi:10.1038/s44321-026-00389-6
DOI: 10.1038/s44321-026-00389-6
Reference: Perdigão C, Torres J, Magnussen HM, Koch J, Rudashevskaya E, Moschref F, Fiosins M, Benseler F, Wenger S, Nilsson T, Beuermann S, Bonn S, Rizzoli SO, Kulathu Y, Jahn O, Cooper BH, Ambrozkiewicz MC, Rhee JS, Brose N & Tirard M (2026) Encephalopathy-linked UFM1 variants impede neuronal protein translation, development, and function. EMBO Molecular Medicine. https://doi.org/10.1038/s44321-026-00389-6

Lyrics:
Verse 1
Long nights under fluorescent hum, cells keep time in quiet rows
Something small goes missing where the folding river flows
The makers slow their hands, the message thins and fades
Branches shrink, the city of the neuron becomes a softer maze

Pre-Chorus
ER whispers folded warnings, a kinase lifts its head
Translation stalls like halted trains on tracks of thread
Tension coils inside the cell, a hush before the tread

Chorus
But we found a pulse to steady the line, a way to prime the light
A molecule that eases heavy rooms and brings the makers back to life
Where once the signals dimmed and synapses fell apart
Now hands rebuild the bridge between a heart and its own spark

Verse 2
Without the small UFM1 guide, the outposts lost their reach
Fewer sparks across the branches, quieter the words they teach
A hypomorphic shadow makes the burden worse when challenged near
Yet when the strain is softened, the fragile circuits reappear

Bridge
Let the piano count the breaths, let the circuits wake and try
A steady rise, a patient swell — the cell learns how to fly
From folded stress to rising tides, the quiet learns to sigh

Final Chorus
Now we give the makers back their rhythm, light through folded walls
Synapses multiply like stars that answer morning calls
Cautious hope becomes a chorus, urgent, warm and bright
We mended the unfinished song and sent it home into the night

This release contains only the music track from Base by Base Episode 298.

Song title: Lights Along the Axoneme
Original Base by Base episode: 298: Bi-allelic FSD1L variants in retinitis pigmentosa implicate photoreceptor axoneme
Original episode link: https://basebybase.com/episodes/fsd1l-retinitis-pigmentosa-axoneme

Article metadata:
Article title: Bi-allelic variants in FSD1L cause retinitis pigmentosa with or without neurological involvement
Journal: The American Journal of Human Genetics, Corrected proof. doi:10.1016/j.ajhg.2026.01.015
DOI: 10.1016/j.ajhg.2026.01.015
Reference: Lin S., Cancellieri F., Cao Y., et al. Bi-allelic variants in FSD1L cause retinitis pigmentosa with or without neurological involvement. The American Journal of Human Genetics 113, 1–11 (2026). https://doi.org/10.1016/j.ajhg.2026.01.015

Lyrics:
Verse 1
In the hush of bright screens, tiny filaments align
Silver threads that carry every scattered sign
A name like a whisper, FSD1L along the line
Tracing light through narrow halls where shadow meets design

Pre-Chorus
There was a gap in a pattern, a slit the eye can feel
An exon folded out of sight, a traffic rule made real
When the map forgets a doorway, signals drift and peel

Chorus
Follow the light along the axoneme, don't let it fade
We hold the missing pieces up until the dark unwinds
From shadow to a filament that finds its way home
We learn the language of the eye and teach the light to roam

Verse 2
Six faces in the pedigrees, a spectrum in their gaze
From steady dusk to restless nights, the retina keeps its ways
Isoforms like different passports, some lost at the gate
A quiet splice, a hidden cut that changes fate

Bridge
In the splice, a tiny deletion, exon ten-b erased
Cells reroute their luggage, outer segments left unlaced
But knowing where the pathway breaks is where the hope is traced

Final Chorus
So follow the light along the axoneme, it calls us on
We read the threads, we map the code until the morning comes
A filament restored, a signal strong enough to sing
Bring the lost exon back to the road — let every photon's voice bring morning

This release contains only the music track from Base by Base Episode 298.

Song title: Lights Along the Axoneme
Original Base by Base episode: 298: Bi-allelic FSD1L variants in retinitis pigmentosa implicate photoreceptor axoneme
Original episode link: https://basebybase.com/episodes/fsd1l-retinitis-pigmentosa-axoneme

Article metadata:
Article title: Bi-allelic variants in FSD1L cause retinitis pigmentosa with or without neurological involvement
Journal: The American Journal of Human Genetics, Corrected proof. doi:10.1016/j.ajhg.2026.01.015
DOI: 10.1016/j.ajhg.2026.01.015
Reference: Lin S., Cancellieri F., Cao Y., et al. Bi-allelic variants in FSD1L cause retinitis pigmentosa with or without neurological involvement. The American Journal of Human Genetics 113, 1–11 (2026). https://doi.org/10.1016/j.ajhg.2026.01.015

Lyrics:
Verse 1
In the hush of bright screens, tiny filaments align
Silver threads that carry every scattered sign
A name like a whisper, FSD1L along the line
Tracing light through narrow halls where shadow meets design

Pre-Chorus
There was a gap in a pattern, a slit the eye can feel
An exon folded out of sight, a traffic rule made real
When the map forgets a doorway, signals drift and peel

Chorus
Follow the light along the axoneme, don't let it fade
We hold the missing pieces up until the dark unwinds
From shadow to a filament that finds its way home
We learn the language of the eye and teach the light to roam

Verse 2
Six faces in the pedigrees, a spectrum in their gaze
From steady dusk to restless nights, the retina keeps its ways
Isoforms like different passports, some lost at the gate
A quiet splice, a hidden cut that changes fate

Bridge
In the splice, a tiny deletion, exon ten-b erased
Cells reroute their luggage, outer segments left unlaced
But knowing where the pathway breaks is where the hope is traced

Final Chorus
So follow the light along the axoneme, it calls us on
We read the threads, we map the code until the morning comes
A filament restored, a signal strong enough to sing
Bring the lost exon back to the road — let every photon's voice bring morning

This release contains only the music track from Base by Base Episode 297.

Song title: Threads of the Mind
Original Base by Base episode: 297: Bi-allelic FSD1L variants disrupt mitotic spindle and ciliogenesis in an L1-like neurodevelopmental disorder
Original episode link: https://basebybase.com/episodes/fsd1l-microtubule-ciliogenesis

Article metadata:
Article title: Bi-allelic variants in FSD1L cause a neurodevelopmental disorder overlapping with L1 syndrome
Journal: The American Journal of Human Genetics, Corrected proof. doi:10.1016/j.ajhg.2026.01.014
DOI: 10.1016/j.ajhg.2026.01.014
Reference: Serpieri V., Vezain-Mouchard M., Orsi A., et al. Bi-allelic variants in FSD1L cause a neurodevelopmental disorder overlapping with L1 syndrome. The American Journal of Human Genetics. 113, 1–16 (March 5, 2026). https://doi.org/10.1016/j.ajhg.2026.01.014

Lyrics:
Verse 1
In the quiet lab, under glass and light,
tiny threads spin, trying to set things right,
a keeper on the spindle, an antenna's friend,
without its steady touch, the pattern frays and bends

Pre-Chorus
Stem cells stall on the edge of becoming,
spheres fold in, the bright plans stop humming,
images whisper halls that widen and hollow,
we hold those images close and try not to follow

Chorus
We trace the broken threads, name the silence in the glow,
we watch the tiny antennas shorten, the currents slow,
but in the dark there rises a signal we can hold,
and light becomes the language that teaches the cold

Verse 2
Microscopes show the spindle's trembling hands,
cells that once would reach now cannot make their plans,
axons lose their compass, bridges fail to grow,
the quiet architecture moves too slow

Bridge
Not a single answer, only threads and questions cast,
each image, each embryo, a story from the past,
we map the fragile pattern and listen to the mind,
searching for the small, steady thing that ties the line

Final Chorus
We trace the broken threads, give them a careful name,
from short cilia to widened halls, we keep the flame,
somber but steady, the finding holds its light,
and in that careful watching we find our way through night

This release contains only the music track from Base by Base Episode 297.

Song title: Threads of the Mind
Original Base by Base episode: 297: Bi-allelic FSD1L variants disrupt mitotic spindle and ciliogenesis in an L1-like neurodevelopmental disorder
Original episode link: https://basebybase.com/episodes/fsd1l-microtubule-ciliogenesis

Article metadata:
Article title: Bi-allelic variants in FSD1L cause a neurodevelopmental disorder overlapping with L1 syndrome
Journal: The American Journal of Human Genetics, Corrected proof. doi:10.1016/j.ajhg.2026.01.014
DOI: 10.1016/j.ajhg.2026.01.014
Reference: Serpieri V., Vezain-Mouchard M., Orsi A., et al. Bi-allelic variants in FSD1L cause a neurodevelopmental disorder overlapping with L1 syndrome. The American Journal of Human Genetics. 113, 1–16 (March 5, 2026). https://doi.org/10.1016/j.ajhg.2026.01.014

Lyrics:
Verse 1
In the quiet lab, under glass and light,
tiny threads spin, trying to set things right,
a keeper on the spindle, an antenna's friend,
without its steady touch, the pattern frays and bends

Pre-Chorus
Stem cells stall on the edge of becoming,
spheres fold in, the bright plans stop humming,
images whisper halls that widen and hollow,
we hold those images close and try not to follow

Chorus
We trace the broken threads, name the silence in the glow,
we watch the tiny antennas shorten, the currents slow,
but in the dark there rises a signal we can hold,
and light becomes the language that teaches the cold

Verse 2
Microscopes show the spindle's trembling hands,
cells that once would reach now cannot make their plans,
axons lose their compass, bridges fail to grow,
the quiet architecture moves too slow

Bridge
Not a single answer, only threads and questions cast,
each image, each embryo, a story from the past,
we map the fragile pattern and listen to the mind,
searching for the small, steady thing that ties the line

Final Chorus
We trace the broken threads, give them a careful name,
from short cilia to widened halls, we keep the flame,
somber but steady, the finding holds its light,
and in that careful watching we find our way through night

This release contains only the music track from Base by Base Episode 296.

Song title: Splice of Fate
Original Base by Base episode: 296: snaR-A ncRNA antagonizes U2 snRNP SF3B2 to drive intron retention in human cells
Original episode link: https://basebybase.com/episodes/snar-a-sf3b2-splicing

Article metadata:
Article title: Cancer-associated snaR-A noncoding RNA interacts with core splicing machinery and disrupts processing of mRNA subpopulations
Journal: Nature Communications, doi:10.1038/s41467-025-65448-x
DOI: 10.1038/s41467-025-65448-x
Reference: Zhou S., Lizarazo S., Chorghade S., Mouli L., Cheng R., Rajendra K. C., Kalsotra A., Van Bortle K. Cancer-associated snaR-A noncoding RNA interacts with core splicing machinery and disrupts processing of mRNA subpopulations. Nature Communications. 2025;16:10460. https://doi.org/10.1038/s41467-025-65448-x

Lyrics:
Verse 1
In the quiet of the nucleus a small script breathes,
snaR-A threads the speckles, slips past the U6 lights,
shadowed currents shift the cadence of our genes.

Pre-Chorus
It finds SF3B2, a hand upon a fragile thread,
pulls at seams of meaning until some words stay dead,
leaving messages half-sung where answers should be said.

Chorus
This is the splice of fate, where lines are kept between,
a tiny RNA that tips the scale and shifts the scene,
growth in shadowed margins, signatures left unseen.

Verse 2
When snaR-A rises, pauses lengthen and hold place,
SF3B2 wanes, the splice slips out of its embrace,
cells speed up their rhythm, others wander, trace.

Bridge
We map the speckled atlas, pull the fragile threads,
turn whispers into markers, stitch the gaps we've read,
a lever for the silence, a light against the spread.

Final Chorus
This is the splice of fate, a small script rearranged,
we read the broken beats and teach the song to change,
from speckle to the surface, a clearer future's framed.

This release contains only the music track from Base by Base Episode 296.

Song title: Splice of Fate
Original Base by Base episode: 296: snaR-A ncRNA antagonizes U2 snRNP SF3B2 to drive intron retention in human cells
Original episode link: https://basebybase.com/episodes/snar-a-sf3b2-splicing

Article metadata:
Article title: Cancer-associated snaR-A noncoding RNA interacts with core splicing machinery and disrupts processing of mRNA subpopulations
Journal: Nature Communications, doi:10.1038/s41467-025-65448-x
DOI: 10.1038/s41467-025-65448-x
Reference: Zhou S., Lizarazo S., Chorghade S., Mouli L., Cheng R., Rajendra K. C., Kalsotra A., Van Bortle K. Cancer-associated snaR-A noncoding RNA interacts with core splicing machinery and disrupts processing of mRNA subpopulations. Nature Communications. 2025;16:10460. https://doi.org/10.1038/s41467-025-65448-x

Lyrics:
Verse 1
In the quiet of the nucleus a small script breathes,
snaR-A threads the speckles, slips past the U6 lights,
shadowed currents shift the cadence of our genes.

Pre-Chorus
It finds SF3B2, a hand upon a fragile thread,
pulls at seams of meaning until some words stay dead,
leaving messages half-sung where answers should be said.

Chorus
This is the splice of fate, where lines are kept between,
a tiny RNA that tips the scale and shifts the scene,
growth in shadowed margins, signatures left unseen.

Verse 2
When snaR-A rises, pauses lengthen and hold place,
SF3B2 wanes, the splice slips out of its embrace,
cells speed up their rhythm, others wander, trace.

Bridge
We map the speckled atlas, pull the fragile threads,
turn whispers into markers, stitch the gaps we've read,
a lever for the silence, a light against the spread.

Final Chorus
This is the splice of fate, a small script rearranged,
we read the broken beats and teach the song to change,
from speckle to the surface, a clearer future's framed.

This release contains only the music track from Base by Base Episode 295.

Song title: Quiet Channel
Original Base by Base episode: 295: CFTR deltaF508 and CF-risk variants protect against IBD in large exome study
Original episode link: https://basebybase.com/episodes/cftr-deltaf508-ibd-protection

Article metadata:
Article title: Cystic fibrosis risk variants confer protection against inflammatory bowel disease
Journal: Cell Genomics, 6 (2026) 101071. doi:10.1016/j.xgen.2025.101071
DOI: 10.1016/j.xgen.2025.101071
Reference: Yu M., Zhang Q., Yuan K., Sazonovs A., Stevens C.R., Fachal L., et al. Cystic fibrosis risk variants confer protection against inflammatory bowel disease. Cell Genomics. 6 (2026) 101071. https://doi.org/10.1016/j.xgen.2025.101071

Lyrics:
Verse 1
In the glow of late-night screens we map the code,
Names and numbers folded into patient rows,
Looking for the doors that change the way things flow,
Curious hands find patterns under quiet lights.

Pre-Chorus
A single shift, a channel eased, a subtle turn,
Stat lines whisper odds and tilt the dark a bit,
Measured hope grows where data clears the blur.

Chorus
When the channel quiets, tides of trouble pull back,
A calmer current runs beneath the surface skin,
Not a miracle, just a change that nudges fate,
Small closing doors that let some healing begin.

Verse 2
Loss of flow reshapes salt and breath along the gut,
Thicker water, steadier film, less flame to feed,
Across the coded map these echoes reappear,
A pattern of protection written in the genes.

Bridge
Think of careful keys that fit a private gate,
Target the organ, spare the rest from needless harm,
There’s promise in the balance — bold but measured steps,
Science keeps the ledger: power, cost, and care.

Final Chorus
When the channel quiets, tides of trouble pull back,
Measured hope rises from a small, persistent change,
We close a door, we find a different kind of light,
A gentle current turning, asking us to try again.

This release contains only the music track from Base by Base Episode 295.

Song title: Quiet Channel
Original Base by Base episode: 295: CFTR deltaF508 and CF-risk variants protect against IBD in large exome study
Original episode link: https://basebybase.com/episodes/cftr-deltaf508-ibd-protection

Article metadata:
Article title: Cystic fibrosis risk variants confer protection against inflammatory bowel disease
Journal: Cell Genomics, 6 (2026) 101071. doi:10.1016/j.xgen.2025.101071
DOI: 10.1016/j.xgen.2025.101071
Reference: Yu M., Zhang Q., Yuan K., Sazonovs A., Stevens C.R., Fachal L., et al. Cystic fibrosis risk variants confer protection against inflammatory bowel disease. Cell Genomics. 6 (2026) 101071. https://doi.org/10.1016/j.xgen.2025.101071

Lyrics:
Verse 1
In the glow of late-night screens we map the code,
Names and numbers folded into patient rows,
Looking for the doors that change the way things flow,
Curious hands find patterns under quiet lights.

Pre-Chorus
A single shift, a channel eased, a subtle turn,
Stat lines whisper odds and tilt the dark a bit,
Measured hope grows where data clears the blur.

Chorus
When the channel quiets, tides of trouble pull back,
A calmer current runs beneath the surface skin,
Not a miracle, just a change that nudges fate,
Small closing doors that let some healing begin.

Verse 2
Loss of flow reshapes salt and breath along the gut,
Thicker water, steadier film, less flame to feed,
Across the coded map these echoes reappear,
A pattern of protection written in the genes.

Bridge
Think of careful keys that fit a private gate,
Target the organ, spare the rest from needless harm,
There’s promise in the balance — bold but measured steps,
Science keeps the ledger: power, cost, and care.

Final Chorus
When the channel quiets, tides of trouble pull back,
Measured hope rises from a small, persistent change,
We close a door, we find a different kind of light,
A gentle current turning, asking us to try again.

This release contains only the music track from Base by Base Episode 294.

Song title: The Splice of Life
Original Base by Base episode: 294: Alternative splicing, exonization and lineage-specific isoforms: PTBP1, MAPT and TE-derived exons in mammalian evolution
Original episode link: https://basebybase.com/episodes/alternative-splicing-exonization-evolution

Article metadata:
Article title: The splice of life: how alternative splicing shapes regulatory and phenotypic evolution
Journal: The EMBO Journal, doi:10.1038/s44318-025-00666-z
DOI: 10.1038/s44318-025-00666-z
Reference: Hunter CE, Xing Y. The splice of life: how alternative splicing shapes regulatory and phenotypic evolution. The EMBO Journal. 2026. https://doi.org/10.1038/s44318-025-00666-z

Lyrics:
Verse 1
Late labs and looping screens where letters shift and slide,
We cut and sew the code, revealing doors we used to hide,
Tiny exons pop like stars, new shapes that redefine,
Isoforms hum their different tunes along the spine.

Pre-Chorus
Across the tree of life the patterns cluster by their kind,
Some changes live in the sequence; some wander from mobile lines,
Alu's small notes can find a voice, a fragment redefined.

Chorus
We call it the splice of life, where choices make a song,
A decoy that calms the storm, a beat that mends a wrong,
A skipped exon tunes the heart, a tau ratio re-sings strong.

Verse 2
Long-read lights and single cells peel isoforms into view,
Mass spec finds the bodies where those coded fragments do come true,
Many edits keep the frame, some outcomes still unknown,
But each revealed possibility becomes a clue, a tone.

Bridge
Cis changes open doors; trans factors rewire the halls,
Old jumps from transposons become new scripts that call,
Evolution drafts in whispers, then the phenotype enthralls.

Final Chorus
This splice, a small conviction that rewrites how we feel,
From immune decoy to faster pulse, the hidden parts reveal,
We stitch the threads of life, and for a moment, it is real.