OrthoJOE

Best Practices for Secondary Analyses in Clinical Trials

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In this episode, Mo and Marc discuss best practices and common challenges in planning secondary analyses from clinical trials, including data collection and analysis protocols, the distinction between primary and secondary questions, hypothesis-driven design, statistical power, process transparency, and dissemination strategies. 

 

Subspecialties: 

  • Trauma 
    • Orthopaedic Essentials 

      •  

      Links: 

      • Shu HT, Hoveidaei AH, Reider LM, Vallier HA, Quinnan S, Gary JL, Carroll EA, Carlini AR, Higgins TF, Bosse MJ, Shafiq B, Tornetta P 3rd, O'Toole RV, Castillo RC; METRC (Major Extremity Trauma Research Consortium). Pain Outcomes Following Modern External Ring Fixation Compared with Internal Fixation for Severe Open Tibial Fractures: A Secondary Analysis of a Prospective Randomized Trial (FIXIT). J Bone Joint Surg Am. 2026 May 6;108(9):649-657. doi: 10.2106/JBJS.25.00964. Epub 2026 Mar 18. PMID: 41849563. https://bit.ly/4fl6E12 
        • ...more
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        OrthoJOEBy Mohit Bhandari and Marc Swiontkowski
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