In this episode of HSS Presents, Dr. Evelyn Murphy joins Dr. S. Robert Rozbruch to discuss a complex case involving a quadrilateral amputee seeking mobility solutions after post-sepsis limb loss; the case was published in the March 2026 issue of "Grand Rounds from HSS: Management of Complex Cases." The discussion highlights the potential of osseointegration limb replacement for patients struggling with traditional socket fit, short residual limbs, and poor soft tissue envelopes. Dr. Rozbruch details the patient selection process, a multi-phase rehabilitation protocol involving gradual loading, and the improvements in proprioception and daily endurance. Touching on surgical innovations like custom 3D-printed implants and concurrent nerve reconstructions, this episode provides a fascinating look at how bone-anchored prosthetics are redefining independence and quality of life for amputees. Read more about the case: HSS Library Link