Techniques such as cell culture proliferation and differentiation are among the most commonly used methods in cell biology research. Since the basic laws of cell behavior are the same in vitro culture and in vivo, many studies can be performed in vitro. More importantly, people can selectively and purposefully control the environment in which cells grow, so they can study the biological behavior of cells under certain special conditions.

The EBV-based immortalization technology enables rapid, efficient, and reliable production of unlimited numbers of personalized cells. As a result, EBV immortalized B cell lines are extensively used as a source of biological material for functional and molecular studies and represent a potentially limitless source of genomic DNA, expression RNA, and protein and system biology analysis.

Bone marrow mesenchymal stem cells (MSCs) are important members of the stem cell family, derived from the mesoderm and ectoderm in the early stages of human body development.

iPSCs (induced pluripotent stem cells) are a class of pluripotent stem cells that are derived from diverse somatic cell types.

The emerging technology of iPSC attracts attention worldwide, giving access to genetic/epigenetic mechanism studies and new drug/methods exploration of neurodegenerative disease by generating patient-specific disease models in vitro.

Induced pluripotent stem cells (iPSCs) are generated by forcing expression of a defined set of transcription factors to reprogram somatic cells into an embryonic pluripotent state. IPSCs can be used in vitro cardiac disease modeling and used for high-throughput pharmacological screenings for drug discovery.

The major barrier may be lacking access to in vitro models that can reflect the natural progression and phenotype of ocular degenerative diseases, to explore molecular pathological mechanism and discover new drug and methods. Induced pluripotent stem cells (iPSCs) are generated by forcing expression of a defined set of transcription factors to reprogram somatic cells into an embryonic pluripotent state, and share the self-renewal and pluripotency characteristics that can be induced to differentiate into multiple types of retinal cells.

The critical component in studying the pathophysiology and etiology of human disease is the requirement of a physiologically relevant experimental disease model that faithfully recapitulates the respective clinical manifestations and pathophysiology. The ground-breaking development of induced pluripotent stem cell (iPSC) technology provides investigators with a self-renewing and unlimited source of pluripotent cells for targeted differentiation and human disease modeling. 

STEMOD™ based High Content Screening

STEMOD™ based Cardiovascular Drugs Screening and Safety Evaluation

According to the mechanisms which closely recapitulate the in vivo microenvironment, applying the stem cells for drug discovery can directly influence drug design and clinical strategies.