Botox recently celebrated its sweet 16, and since 2002, has gone from controversial to must have cure for wrinkles, migraines, TMJ, sweating.

Amber and Ryan put it all on the table and breakdown their favorite anti-aging treatment:

• Is it a miracle cure or just a gateway drug to plastic surgery?

• When is enough enough?

• Should your friends have a safe word?

Get the "real truth about the fake sh-t"  in the premiere episode of Art Beauty.