David Boas, director of the Boston University Neurophotonics Center, is our guest. The episode introduces techniques including functional near-infrared spectroscopy (fNIRS), laser speckle contrast imaging, optical coherence tomography (OCT), and interferometric diffuse correlation spectroscopy, with expert insight on the advances and neurophotonic applications for each method. Boas is founding editor-in-chief of the journal Neurophotonics published by SPIE, and he is founding president of the Society for Functional Near-Infrared Spectroscopy — a technique with practical application in wearable technology.