In episode 602, James and Mike Kolber go over the best available evidence for the benefits and the harms for one of the most commonly used classes of medications – proton pump inhibitors. We find out the benefit numbers are much larger than the harm numbers. Check out the podcast to get all the numbers you need to help people make decisions.

Show Notes 1) Tools For Practice Side effects of long-term PPI use: Leaving a bad taste in your mouth? Proton Pump Inhibitors (PPIs): Is Perpetual Prescribing Inevitable?

2) PEIP Conference Edmonton October 17-18, 2025

3) SPARCTool

4) RX files PPI Stopping your Proton Pump Inhibitor or "PPI"