Although there’s currently no cure for schizophrenia, it can be managed with therapy and medication—for some patients, that is. In fact, up to one-half of patients with severe symptoms don’t respond to medication. So how are we to care for this large percentage of patients living with treatment-resistant schizophrenia? That’s the question Dr. Andrew Wilner asks Dr. Nicola Cascella, an Assistant Professor of Psychiatry and Behavioral Sciences at Johns Hopkins University School of Medicine who recently conducted a case study exploring the potential use of deep brain stimulation for patients with treatment-resistant schizophrenia.