In this episode of HSS Presents, Dr. Peter Sculco sits down with colleague Dr. Alberto Carli, a specialist in hip and knee arthroplasty and infection, to discuss the current state and future of periprosthetic joint infection (PJI). They cover the evolving diagnostic landscape, indications for DAIR versus implant removal, and the key elements of a high-quality debridement, including antiseptic solutions and the growing role of intraosseous vancomycin. For surgeons managing these challenging cases or looking to standardize their infection protocol, this is essential listening.