“The research team treated AD model mice with gossypetin through intragastric administration for three months and concluded that their impaired memory and cognition were almost restored to the normal level. (13wk) Furthermore, they saw a decrease in the various types of Aβ aggregates, which are commonly found in the brain tissue with AD-type dementia.

#gossypetin #hibiscus #alzheimers

Kyung Won Jo, Dohyun Lee, Dong Gon Cha, Eunji Oh, Yoon Ha Choi, Somi Kim, Eun Seo Park, Jong Kyoung Kim, Kyong-Tai Kim. Gossypetin ameliorates 5xFAD spatial learning and memory through enhanced phagocytosis against Aβ. Alzheimer's Research & Therapy, 2022; 14 (1) DOI: 10.1186/s13195-022-01096-3

Hibiscus, gossypetin, amyloid, tau, flavonoid, alzheimers, microgila, phagocytes, dementia, amyloid-beta, Hibiscus sabdariffa, roselle, ruby red hibiscus, phagocytosis, cognitive decline, memory loss

"Our study provides novel insights on how brain metabolism relates to behavior and puts forward nutritional interventions targeting key oxidative process as ideal interventions to facilitate effortful endurance," conclude the authors. The study's findings "suggest that improvement of accumbal antioxidant function may be a feasible approach to boost motivation."

#NAC #nucleusaccumbens #motivation

Eva Ramos-Fernández, Ioannis Zalachoras, Fiona Hollis, Laura Trovo, João Rodrigues, Alina Strasser, Olivia Zanoletti, Pascal Steiner, Nicolas Preitner, Lijing Xin, Simone Astori, Carmen Sandi. Glutathione in the nucleus accumbens regulates motivation to exert reward-incentivized effort. eLife, 2022; 11 DOI: 10.7554/eLife.77791

NAC, Nucleus Accumbens, motivation, effort , glutathione, N-acetylcysteine, oxidative stress, GSH, persistence, antioxidant, ros, brain, reward, accumbal GSH, behavior, NuAc, accumbal antioxidant, effortful endurance, nutritional interventions

Motivation Increased With NAC / (GSH)

"Our study provides novel insights on how brain metabolism relates to behavior and puts forward nutritional interventions targeting key oxidative process as ideal interventions to facilitate effortful endurance," conclude the authors. The study's findings "suggest that improvement of accumbal antioxidant function may be a feasible approach to boost motivation."

#NAC #nucleusaccumbens #motivation

Eva Ramos-Fernández, Ioannis Zalachoras, Fiona Hollis, Laura Trovo, João Rodrigues, Alina Strasser, Olivia Zanoletti, Pascal Steiner, Nicolas Preitner, Lijing Xin, Simone Astori, Carmen Sandi. Glutathione in the nucleus accumbens regulates motivation to exert reward-incentivized effort. eLife, 2022; 11 DOI: 10.7554/eLife.77791

NAC, Nucleus Accumbens, motivation, effort , glutathione, N-acetylcysteine, oxidative stress, GSH, persistence, antioxidant, ros, brain, reward, accumbal GSH, behavior, NuAc, accumbal antioxidant, effortful endurance, nutritional interventions

Wearing special green eyeglasses for several hours a day reduces pain-related anxiety and may help decrease the need for opioids to manage severe pain in fibromyalgia patients and possibly others who experience chronic pain, according to a study being presented at the ANESTHESIOLOGY® 2022 annual meeting.

#green #anxiety #fibromyalgia

Effects Of Light Induced Analgesia On Anxiety For Fibromyalgia Patients Padma Gulur, M.D., Mary Wright, MS, Amanda Nelli, M.D. Duke University, Chapel Hill, North Carolina, United States A2094 October 23, 2022 American Society of Anesthesiologists

https://www.medpagetoday.com/meetingcoverage/asa/101375

https://www.painnewsnetwork.org/s/A2094-Effects-Of-Light-Induced-Analgesia-On-Anxiety-For-Fibromyalgia-Patients.pdf

Green light, green glasses, fibromyalgia, anxiety, fear, opioid, pain, pain reduction, pain relief, chronic pain, pain control, green

Green Glasses may reduce Fear based Anxiety and Opioid Use

Wearing special green eyeglasses for several hours a day reduces pain-related anxiety and may help decrease the need for opioids to manage severe pain in fibromyalgia patients and possibly others who experience chronic pain, according to a study being presented at the ANESTHESIOLOGY® 2022 annual meeting.

#green #anxiety #fibromyalgia

Effects Of Light Induced Analgesia On Anxiety For Fibromyalgia Patients Padma Gulur, M.D., Mary Wright, MS, Amanda Nelli, M.D. Duke University, Chapel Hill, North Carolina, United States A2094 October 23, 2022 American Society of Anesthesiologists

https://www.medpagetoday.com/meetingcoverage/asa/101375

https://www.painnewsnetwork.org/s/A2094-Effects-Of-Light-Induced-Analgesia-On-Anxiety-For-Fibromyalgia-Patients.pdf

Green light, green glasses, fibromyalgia, anxiety, fear, opioid, pain, pain reduction, pain relief, chronic pain, pain control, green

AKG may increase exercise performance and muscle size Episode 1108 Fall 2022

Previous studies have shown that AKG plays biological functions such as regulating energy metabolism, promoting osteogenesis, improving immunity, and prolonging life span of animal organism

#AKG #musclegrowth #muscleendurance

Jinping Yang, Guli Xu, Yiming Xu, Pei Luo, Yexian Yuan, Lin Yao, Jingjing Zhou, Yunlong Zhu, Ishwari Gyawali, Chang Xu, Jinlong Feng, Zewei Ma, Yuxian Zeng, Songbo Wang, Ping Gao, Canjun Zhu, Qingyan Jiang, Gang Shu, AKG/OXGR1 promotes skeletal muscle blood flow and metabolism by relaxing vascular smooth muscle, Life Metabolism, 2022;, loac026, https://doi.org/10.1093/lifemeta/loac026

TCA, AKG, α-Ketoglutarate, alpha Ketoglutarate, muscle mass, metabolism, . Oxoglutarate receptor, muscle aging, OXGR1, type 1, exercise performance, endurance hypertrophy , tricarboxylic acid cycle, nerve regulation, hormone secretion, blood flow, fat deposition, slow oxidizing, angiogenesis, muscle growth, muscle size, vascular perfusion, skeletal muscle, krebs, citric

AKG may increase exercise performance and muscle size Episode 1108 Fall 2022

Previous studies have shown that AKG plays biological functions such as regulating energy metabolism, promoting osteogenesis, improving immunity, and prolonging life span of animal organism

#AKG #musclegrowth #muscleendurance

Jinping Yang, Guli Xu, Yiming Xu, Pei Luo, Yexian Yuan, Lin Yao, Jingjing Zhou, Yunlong Zhu, Ishwari Gyawali, Chang Xu, Jinlong Feng, Zewei Ma, Yuxian Zeng, Songbo Wang, Ping Gao, Canjun Zhu, Qingyan Jiang, Gang Shu, AKG/OXGR1 promotes skeletal muscle blood flow and metabolism by relaxing vascular smooth muscle, Life Metabolism, 2022;, loac026, https://doi.org/10.1093/lifemeta/loac026

TCA, AKG, α-Ketoglutarate, alpha Ketoglutarate, muscle mass, metabolism, . Oxoglutarate receptor, muscle aging, OXGR1, type 1, exercise performance, endurance hypertrophy , tricarboxylic acid cycle, nerve regulation, hormone secretion, blood flow, fat deposition, slow oxidizing, angiogenesis, muscle growth, muscle size, vascular perfusion, skeletal muscle, krebs, citric

Licorice Compounds and their Amazing Potential

GL Glycyrrhizin and its derivative, glycyrrhetinic acid ( GA , exhibit a wide range of activities to elicit their oncoprotective and oncotherapeutic effects. The effects range from inducing cell cycle arrest, inducing apoptosis, inhibiting invasion and metastasis, immunomodulation, attenuating the inflammatory microenvironment in cancer to antioxidants, sensitizing the tumor to other drugs, and protecting from conventional therapy side effects

#licorice #Glycyrrhizin #glycyrrhetinicacid

Rifika Jain, Mohamed Ali Hussein, Shannon Pierce, Chad Martens, Preksha Shahagadkar, Gnanasekar Munirathinam, Oncopreventive and oncotherapeutic potential of licorice triterpenoid compound glycyrrhizin and its derivatives: Molecular insights,Pharmacological Research,Volume 178,2022,106138,ISSN 1043-6618, https://doi.org/10.1016/j.phrs.2022.106138.

Licorice, Glycyrrhizin, glycyrrhetinic, anti inflammatory, metastasis, immunomodulation, oncoprotective,  oncotherapeutic, apoptosis, antioxidant, gza, gl, ga, Anti-estrogenic, chemotherapy,

Licorice Compounds and their Amazing Potential

GL Glycyrrhizin and its derivative, glycyrrhetinic acid ( GA , exhibit a wide range of activities to elicit their oncoprotective and oncotherapeutic effects. The effects range from inducing cell cycle arrest, inducing apoptosis, inhibiting invasion and metastasis, immunomodulation, attenuating the inflammatory microenvironment in cancer to antioxidants, sensitizing the tumor to other drugs, and protecting from conventional therapy side effects

#licorice #Glycyrrhizin #glycyrrhetinicacid

Rifika Jain, Mohamed Ali Hussein, Shannon Pierce, Chad Martens, Preksha Shahagadkar, Gnanasekar Munirathinam, Oncopreventive and oncotherapeutic potential of licorice triterpenoid compound glycyrrhizin and its derivatives: Molecular insights,Pharmacological Research,Volume 178,2022,106138,ISSN 1043-6618, https://doi.org/10.1016/j.phrs.2022.106138.

Licorice, Glycyrrhizin, glycyrrhetinic, anti inflammatory, metastasis, immunomodulation, oncoprotective,  oncotherapeutic, apoptosis, antioxidant, gza, gl, ga, Anti-estrogenic, chemotherapy,

Licorice Compounds and their Amazing Potential

GL Glycyrrhizin and its derivative, glycyrrhetinic acid ( GA , exhibit a wide range of activities to elicit their oncoprotective and oncotherapeutic effects. The effects range from inducing cell cycle arrest, inducing apoptosis, inhibiting invasion and metastasis, immunomodulation, attenuating the inflammatory microenvironment in cancer to antioxidants, sensitizing the tumor to other drugs, and protecting from conventional therapy side effects

#licorice #Glycyrrhizin #glycyrrhetinicacid

Rifika Jain, Mohamed Ali Hussein, Shannon Pierce, Chad Martens, Preksha Shahagadkar, Gnanasekar Munirathinam, Oncopreventive and oncotherapeutic potential of licorice triterpenoid compound glycyrrhizin and its derivatives: Molecular insights,Pharmacological Research,Volume 178,2022,106138,ISSN 1043-6618, https://doi.org/10.1016/j.phrs.2022.106138.

Licorice, Glycyrrhizin, glycyrrhetinic, anti inflammatory, metastasis, immunomodulation, oncoprotective,  oncotherapeutic, apoptosis, antioxidant, gza, gl, ga, Anti-estrogenic, chemotherapy,