A variety of eye disorders can occur as humans age, including age-related macular degeneration, cataracts, presbyopia, glaucoma, dry eyes, and temporal arteritis. These conditions can contribute to vision impairment and even vision loss. Unfortunately, the full gambit of common age-related eye lens changes which contribute to these disorders is not yet fully defined. However, while mice and primates are different species, their eye lenses share common characteristics. This means that studies in murine models regarding age-related eye lens changes may provide a baseline for aging studies on human eye lenses in the future.

“Little is known about the morphological, mechanical, refractive and cellular changes that occur with advanced age in the lens. Mice offer an opportunity to investigate changes in lens morphometrics, stiffness, transparency and refractive properties with age in a relatively shortened period of time.”

To further define common age-related changes in eye lenses, researchers—from The Scripps Research Institute, University of Delaware, Morehouse School of Medicine, Nottingham Trent University, Japan Synchrotron Radiation Research Institute, and Boston University School of Medicine—conducted an extensive study of eye lenses among mice between one and 30 months of age. Their paper was published by Aging (Aging-US) in 2019, and entitled, “Age-related changes in eye lens biomechanics, morphology, refractive index and transparency.”

Full bog - https://www.impactjournals.com/journals/blog/trending-with-impact/common-age-related-changes-in-eye-lenses/

Special collection on eye disease - https://www.aging-us.com/special-collections-archive/eye-disease

Press release - https://www.aging-us.com/news_room/age-related-changes-in-eye-lens-biomechanics

Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.102584

DOI - https://doi.org/10.18632/aging.102584

Full text - https://www.aging-us.com/article/102584/text

Correspondence to: Velia M. Fowler email: [email protected] and Catherine Cheng email: [email protected]

Keywords: fiber cell, strain, epithelial cell, cataract, stiffness

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

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