In this episode, we discuss common genetic and proteins implicated with Autism. This episode is all about preparing for a future episode about Excitation and Inhibition imbalance- a known phenomena with Autism. I play Tug-of-War with Barbed-Wire and talk about a critical factor of our environment implicating proteins and development- This is huge, and necessary.

Genomic Architecture of Autism https://www.cell.com/cell/pdf/S0092-8674(22)01324-1.pdf

PTEN and mTOR https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01435-8?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124722014358%3Fshowall%3Dtrue

16p11.2, Serotonin, and Possible Social Deficit Rescues

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824539/

https://www.nature.com/articles/s41586-018-0416-4

https://www.nature.com/articles/s41386-021-01091-6

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606557/

Dr. Jack Kruse on Autism https://jackkruse.com/category/autism/

Cullin 3 / Cul3 https://pubmed.ncbi.nlm.nih.gov/31455858/

SHANK3 https://pubmed.ncbi.nlm.nih.gov/?term=shank3

Neurexin and Neuroligin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120877/

https://www.sciencedirect.com/science/article/pii/S0092867414006734

(0:00) Introduction; Excitation and Inhibition;

(3:15) Phosphate and Tensin- Pten; Synapses, Soma Size, Migration, Cellular Spine Density, Dendritic Overgrowth, Myelination; mTOR (Rapamycin) and hope; Are cells doing what they should?

(10:18) 16p11.2; Serotonin; Raphe and Nucleus Accumbens; Possible Therapeutic Help;

(13:40) NEED TO KNOW INFORMATION; Tryptophan, Aromatic Amino Acids, UV-B Light and Proteins; Changes in our Light Environment and Implications to our Biology and Modern Health Concerns; Photoreceptors and Brain and Skin Connection- Neuroectoderm; Circadian Mismatch;

(19:24) Back to 16p11.2 and Cortical Development;

(22:00) Cullin 3 and Cul3 and Implications to Socialness and Sensory-Gating; Causes of Stereotypic Behaviors; Neuronal Excitability;

(24:09) SHANK3; Tissues and Brain; Synaptic Implications; more Spine and Dendritic formation; Sensory Processing; Repetitive Behaviors; Anxiety; Social Deficits; Poor Motor Coordination;

(25:59) Neurexin and Neuroligin; Synaptic development and action; Myelination; E/I and Spine; CNTNAP2 and mPFC

(29:25) Wrap Up and Contact Information

email: [email protected]