CrashCourse

Hank imagines himself breaking into the Hot Pockets factory to steal their secret recipes and instruction manuals in order to help us understand how the processes known as DNA transcription and translation allow our cells to build proteins.

Table of Contents:
1) Transcription 2:12
A) Transcription Unit 3:00
B) Promoter 3:10
C) TATA Box 3:32
D) RNA Polymerase 4:12
E) mRNA 4:15
F) Termination signal 5:21
G) 5' Cap & Poly-A Tail 5:34
2) RNA Splicing 6:08
A) SNuRPs & Spliceosome 6:26
B) Exons & Introns 6:56
3) Translation 7:28
A) mRNA & tRNA 8:01
B) Triplet Codons & Anticodons 8:39
4) Folding & Protein Structure 10:51
A) Primary Structure 11:11
B) Secondary Structure 11:23
C) Tertiary Structure 11:58
D) Quaternary Structure 12:44

Links to episodes referenced in the video:
DNA structure episode: http://www.youtube.com/watch?v=8kK2zwjRV0M
Animal cells episode: http://www.youtube.com/watch?v=cj8dDTHGJBY
Fold-it SciShow episode: http://www.youtube.com/watch?v=JdBcpdH_ptA

This video contains the following sounds from Freesound.org:
"IMPresora.wav" by melack
"swishes.wav" by pogotron

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In 2010, a NASA-backed study boldly announced that we’d found alien life right here on Earth. So where are all these aliens? In this episode of Crash Course Scientific Thinking, we search for the truth and learn how science is an ongoing quest for knowledge that double-checks itself through peer review.

Introduction: Alien Life? 00:00
Arsenic-based Life 0:28
Peer Review 2:55
Replication 6:06
The Scientific Process 8:25
Review & Credits 9:25

Sources: https://docs.google.com/document/d/1Kv2_mFsDxQURuFDxpflD45dy-pCxlqnM9iPSNYxigmQ/edit?tab=t.0#heading=h.vk5i2fgqyumq

***
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Thanks to the following patrons for their generous monthly contributions that help keep Crash Course free for everyone forever:
Mitch Gresko, Roger Harms, Brandon Thomas, Ken Davidian, AThirstyPhilosopher ., Michael Maher, Johnathan Williams, Chelsea S, oranjeez, EllenBryn, Katrix , Evan Nelson, Shruti S, UwU, Leah H., Allison Wood, Thomas Sully, Jennifer Wiggins-Lyndall, Dalton Williams, Quinn Harden, Chuck Smith, Andrew Woods, Kevin Knupp, Rie Ohta, Jason Terpstra, NassauLinda, Martin G. Diller, Matthew Fredericksen, Gina Mancuso, Elizabeth LaBelle, DexcilaDou, Barbara Pettersen, SpaceRangerWes, Emily Beazley, David Fanska, Reed Spilmann, Pietro Gagliardi, Jason Rostoker, Toni Miles, Les Aker, Alex Hackman, Liz Wdow, Wai Jack Sin, team dorsey, Rizwan Kassim, Eric Koslow, John Lee, Triad Terrace, Duncan W Moore IV, Matt Curls, ClareG, Emily T, Kristina D Knight, Stephen McCandless, Barrett, Bernardo Garza, Katie Dean, Laurel Stevens, Ian Dundore, Thomas, Trevin Beattie, Steve Segreto, Joseph Ruf, Nathan Taylor, Constance Urist, Jason Buster, Stephen Akuffo, Sarah & Nathan Catchings, Kyle & Katherine Callahan, Perry Joyce, Ken Penttinen, Tanner Hedrick, Scott Harrison, Jennifer Killen, Breanna Bosso, Alan Bridgeman, Siobhán, Krystle Young, Indija-ka Siriwardena, Samantha, Evol Hong, Tandy Ratliff, Erminio Di Lodovico, Luke Sluder, Caleb Weeks
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In which John Green teaches you the history of Christianity, from the beginnings of Judaism and the development of monotheism, right up to Paul and how Christianity stormed the Roman Empire in just a few hundred years. Along the way, John will cover Abram/Abraham, the Covenant, the Roman Occupation of Judea, and the birth, life, death, and legacy of Jesus of Nazareth. No flame wars! Let's keep the commentary civil.

Chapters:
Introduction: The Son of God 00:00
Understanding the Jewish Tradition 0:33
Herod and Herod - Roman Rulers 3:32
Jesus of Nazareth 4:27
Why did people believe Jesus was the Messiah? 5:56
Why was Jesus so influential? 7:39
Saul / Paul of Tarsus 8:38
An Open Letter to The Fish (Ichthys) 9:16
How Christianity Survived 10:13
Credits 11:06

Crash Course is on Patreon! You can support us directly by signing up at http://www.patreon.com/crashcourse

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Although we've spent a lot of time in this series looking at human-made organic chemicals, the term "organic chemistry" was originally used to describe molecules isolated from living things. In this episode of Crash Course Organic Chemistry, we're going back to our roots to learn more about the best synthetic chemists: living things. We'll look at the biochemical building blocks of life from the nitrogenous bases, sugars, and phosphate groups that make up DNA and RNA, to amino acids and lipids, and we'll learn how to convert between Fischer and Haworth projections of carbohydrates.

Series Sources:
Brown, W. H., Iverson, B. L., Ansyln, E. V., Foote, C., Organic Chemistry; 8th ed.; Cengage Learning, Boston, 2018.
Bruice, P. Y., Organic Chemistry, 7th ed.; Pearson Education, Inc., United States, 2014.
Clayden, J., Greeves, N., Warren., S., Organic Chemistry, 2nd ed.; Oxford University Press, New York, 2012.
Jones Jr., M.; Fleming, S. A., Organic Chemistry, 5th ed.; W. W. Norton & Company, New York, 2014.
Klein., D., Organic Chemistry; 1st ed.; John Wiley & Sons, United States, 2012.
Louden M., Organic Chemistry; 5th ed.; Roberts and Company Publishers, Colorado, 2009.
McMurry, J., Organic Chemistry, 9th ed.; Cengage Learning, Boston, 2016.
Smith, J. G., Organic chemistry; 6th ed.; McGraw-Hill Education, New York, 2020.
Wade., L. G., Organic Chemistry; 8th ed.; Pearson Education, Inc., United States, 2013.

***
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Crash Course is on Patreon! You can support us directly by signing up at http://www.patreon.com/crashcourse

Thanks to the following patrons for their generous monthly contributions that help keep Crash Course free for everyone forever:
Dave Freeman, Hasan Jamal, DL Singfield, Lisa Owen, Jeremy Mysliwiec, Amelia Ryczek, Ken Davidian, Stephen Akuffo, Toni Miles, Erin Switzer, Steve Segreto, Michael M. Varughese, Kyle & Katherine Callahan, Laurel Stevens, Vincent, Michael Wang, Stacey Gillespie (Stacey J), Alexis B, Burt Humburg, Aziz Y, Shanta, DAVID MORTON HUDSON, Perry Joyce, Scott Harrison, Mark & Susan Billian, Junrong Eric Zhu, Rachel Creager, Breanna Bosso, Matt Curls, Tim Kwist, Jonathan Zbikowski, Jennifer Killen, Sarah & Nathan Catchings, team dorsey, Trevin Beattie, Divonne Holmes à Court, Eric Koslow, Jennifer, Dineen, Indika Siriwardena, Khaled El Shalakany, Jason Rostoker, Shawn Arnold, Siobhán, Ken Penttinen, Nathan Taylor, Les Aker, ClareG, Rizwan Kassim, Alex Hackman, Jirat, Katie Dean, Avi Yashchin, NileMatotle, Wai Jack Sin, Ian Dundore, Justin, Mark, Caleb Weeks
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Lights, camera, action! Latin American literature intersects with all sorts of other kinds of art, including film. In this episode of Crash Course Latin American Literature, we explore the exchange between these two art forms, and how one piece of pop culture can help illuminate another.

Introduction: At the Movies 00:00
Manuel Puig 0:35
Alberto Fuguet & McOndo 3:49
Book-to-Screen Adaptations 7:46
Review & Credits 10:05

Sources: https://docs.google.com/document/d/1eE7g4-k6PD7C6wNBzeJIO8GCDHpoJl8ldDjKyq_2yYg/edit?tab=t.0
To learn more, check out these videos:

https://www.youtube.com/playlist?list=PL8dPuuaLjXtN-Bd-H_TGq72CN50Fpv_JX
https://www.youtube.com/playlist?list=PL8dPuuaLjXtOCicti5dwLAKuesMQVi7hw https://youtu.be/_wx8XooVlVs?si=eiluqnk2O5ww3Kdm https://youtu.be/ftcvaJCKVjs?si=vO15MjvCWidAd-J6
https://youtu.be/YWNcCs__vQg?si=_wYs4tsONAaVxhF0 https://youtu.be/Hlpv7nKt81A?si=yosEHoKHsVELOKBT

Check out our CC Latin America Extra Curricular Playlist here:
https://www.youtube.com/playlist?list=PL8dPuuaLjXtPTzMxnHVWhrV8dUZM0qL34

***
Support us for $5/month on Patreon to keep Crash Course free for everyone forever! https://www.patreon.com/crashcourse
Or support us directly: https://complexly.com/support
Join our Crash Course email list to get the latest news and highlights: https://mailchi.mp/crashcourse/email
Get our special Crash Course Educators newsletter: http://eepurl.com/iBgMhY

Thanks to the following patrons for their generous monthly contributions that help keep Crash Course free for everyone forever:
Mitch Gresko, Roger Harms, Brandon Thomas, Ken Davidian, AThirstyPhilosopher ., Michael Maher, Johnathan Williams, Chelsea S, oranjeez, EllenBryn, Katrix , Evan Nelson, Shruti S, UwU, Leah H., Allison Wood, Thomas Sully, Jennifer Wiggins-Lyndall, Dalton Williams, Quinn Harden, Chuck Smith, Andrew Woods, Kevin Knupp, Rie Ohta, Jason Terpstra, NassauLinda, Martin G. Diller, Matthew Fredericksen, Gina Mancuso, Elizabeth LaBelle, DexcilaDou, Barbara Pettersen, SpaceRangerWes, Emily Beazley, David Fanska, Reed Spilmann, Pietro Gagliardi, Jason Rostoker, Toni Miles, Les Aker, Alex Hackman, Liz Wdow, Wai Jack Sin, team dorsey, Rizwan Kassim, Eric Koslow, John Lee, Triad Terrace, Duncan W Moore IV, Matt Curls, ClareG, Emily T, Kristina D Knight, Stephen McCandless, Barrett, Bernardo Garza, Katie Dean, Laurel Stevens, Ian Dundore, Thomas, Trevin Beattie, Steve Segreto, Joseph Ruf, Nathan Taylor, Constance Urist, Jason Buster, Stephen Akuffo, Sarah & Nathan Catchings, Kyle & Katherine Callahan, Perry Joyce, Ken Penttinen, Tanner Hedrick, Scott Harrison, Jennifer Killen, Breanna Bosso, Alan Bridgeman, Siobhán, Krystle Young, Indija-ka Siriwardena, Samantha, Evol Hong, Tandy Ratliff, Erminio Di Lodovico, Luke Sluder, Caleb Weeks
__

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Hank introduces us to that wondrous molecule deoxyribonucleic acid - also known as DNA - and explains how it replicates itself in our cells.

References:
http://www.nature.com/nature/dna50/watsoncrick.pdf
http://publications.nigms.nih.gov/thenewgenetics/chapter1.html
http://rst.gsfc.nasa.gov/Sect20/A12.html
http://www.nature.com/scitable/topicpage/discovery-of-dna-structure-and-function-watson-397
http://www.uic.edu/classes/phys/phys461/phys450/ANJUM04/
http://www.buzzle.com/articles/dna-replication-steps.html
http://www.dnareplication.info/stepsofdnareplication.php
http://salamandercandy.wordpress.com/2007/02/05/how-much-dna/
http://www.sdsc.edu/ScienceWomen/franklin.html
http://www.fmi.ch/members/marilyn.vaccaro/ewww/dna.pioneer.excerpt.htm
http://www.strangescience.net/rfranklin.htm

1:41 link to Biological Molecules http://www.youtube.com/watch?v=H8WJ2KENlK0

Table of Contents:
1) Nucleic Acids 1:30
2) DNA
-A) Polymers 1:53
-B) Three Ingredients 2:12
-C) Base Pairs 3:45
-D) Base Sequences 4:13
3) Pop Quiz 5:07
4) RNA 5:36
-A) Three Differences from DNA 5:43
5) Biolography 6:16
6) Replication 8:49
-A) Helicase and Unzipping 9:22
-B) Leading Strand 9:38
-C) DNA Polymerase 10:08
-D) RNA Primase 10:24
-E) Lagging Strand 10:46
-F) Okazaki Fragments 11:07
-F) DNA Ligase 11:47

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Oh my, Craig has his work cut out for him this week. The process of how a bill becomes a law can be pretty complex, fraught with potential bill-death at every corner. As if just getting through committee isn’t difficult enough, bills have to navigate a series of amendments and votes in both houses, potentially more committees, further compromise bills, and even more floor votes, just to end up on the chopping block of the President. And then in one fell swoop, the President can stop a bill in its tracks with a veto! But then again, a presidential veto isn’t necessarily a bill’s end either.

As you can see we’ve got to lot to cover, and we’ll be the first to admit this has been covered before, and extraordinarily well might we add, by the folks at School House Rock. But we’ll give it our best shot - without the singing of course. Well, not too much singing anyway.

Support is provided by Voqal: http://www.voqal.org
This episode is sponsored by Squarespace: http://www.squarespace.com/crashcourse

Chapters:
Introduction: How a Bill Becomes a Law 00:00
Bill introduction 0:49
Committee referral 1:02
Senate rules 1:35
The bill passes the other chamber 1:59
Conference committee 2:19
The President signs the law 2:39
Vetos & Pocket Vetos 2:45
Overriding a veto 3:15
Why do so few laws get passed? 3:57
Places a bill can die 4:14
Veto gates 5:02
Why Congress has so many procedural hurdles 5:52
Credits 6:28

Crash Course is on Patreon! You can support us directly by signing up at http://www.patreon.com/crashcourse

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Literature doesn’t begin and end when a writer puts words on a page. In our final episode of Crash Course Latin American Literature, we’ll explore how literature is shaped by readers and translators, too.

Introduction: A Mysterious Library 00:00
"La Biblioteca de Babel" 0:39
Roberto Bolaño 3:14
Translation 5:20
Review & Credits 8:56

Sources: https://docs.google.com/document/d/1eE7g4-k6PD7C6wNBzeJIO8GCDHpoJl8ldDjKyq_2yYg/edit?tab=t.0
To learn more, check out these videos:
https://youtu.be/YWNcCs__vQg?si=_wYs4tsONAaVxhF0 https://youtu.be/Hlpv7nKt81A?si=yosEHoKHsVELOKBT
https://youtu.be/rjhIzemLdos?si=tnGlApmXWA4Rz-em https://youtu.be/ZBw35Ze3bg8?si=SbYqxJZM54AHr0IR
https://youtu.be/MSYw502dJNY?si=861vBgxaeBf0sXaT

Check out our CC Latin America Extra Curricular Playlist here:
https://www.youtube.com/playlist?list=PL8dPuuaLjXtPTzMxnHVWhrV8dUZM0qL34

***
Support us for $5/month on Patreon to keep Crash Course free for everyone forever! https://www.patreon.com/crashcourse
Or support us directly: https://complexly.com/support
Join our Crash Course email list to get the latest news and highlights: https://mailchi.mp/crashcourse/email
Get our special Crash Course Educators newsletter: http://eepurl.com/iBgMhY

Thanks to the following patrons for their generous monthly contributions that help keep Crash Course free for everyone forever:
NassauLinda, Chuck Smith, DexcilaDou, Martin G. Diller, Johnathan Williams, Allison Wood, Katrix , Jason Terpstra, Evan Nelson, Jennifer Wiggins-Lyndall, SpaceRangerWes, Dalton Williams, Chelsea S, Matthew Fredericksen, AThirstyPhilosopher ., Michael Maher, Mitch Gresko, Gina Mancuso, Roger Harms, Shruti S, Quinn Harden, Reed Spilmann, Brandon Thomas, Emily Beazley, Rie Ohta, oranjeez, UwU, Elizabeth LaBelle, Leah H., David Fanska, Andrew Woods, Kevin Knupp, Barbara Pettersen, Ken Davidian, Stephen Akuffo, Toni Miles, Steve Segreto, Kyle & Katherine Callahan, Laurel Stevens, Tanner Hedrick, Kristina D Knight, Samantha, Krystle Young, Scott Harrison, Alan Bridgeman, Breanna Bosso, Matt Curls, Liz Wdow, Jennifer Killen, Duncan W Moore IV, Sarah & Nathan Catchings, team dorsey, Bernardo Garza, Trevin Beattie, Pietro Gagliardi, John Lee, Eric Koslow, Indija-ka Siriwardena, Jason Rostoker, Siobhán, Ken Penttinen, Nathan Taylor, Barrett, Les Aker, ClareG, Rizwan Kassim, Constance Urist, Alex Hackman, Triad Terrace, Katie Dean, Jason Buster, Emily T, Stephen McCandless, Thomas, Joseph Ruf, Wai Jack Sin, Ian Dundore, Erminio Di Lodovico, Evol Hong, Tandy Ratliff, Caleb Weeks, Luke Sluder
__

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In which John Green explores exactly when Rome went from being the Roman Republic to the Roman Empire. Here's a hint: it had something to do with Julius Caesar, but maybe less than you think. Find out how Caesar came to rule the empire, what led to him getting stabbed 23 times on the floor of the senate, and what happened in the scramble for power after his assassination. John covers Rome's transition from city-state to dominant force in the Mediterranean in less than 12 minutes. Well, Rome's expansion took hundreds of years, he just explains it in under 12 minutes. The senate, the people, Rome, the caesarian section, the Julian calendar, and our old friend Pompey all make appearances, but NOT the Caesar Salad, as Julius had nothing to do with it.

Chapters:
Introduction: SPQR 00:00
The Roman Republic 0:41
The Roman Senate 1:15
Cincinnatus 2:14
Gaius Julius Caesar 2:49
The First Triumvirate: Pompey, Crassus, and Caesar 3:40
The End of Caesar's Reign 5:22
The Second Triumvirate: Octavian, Mark Antony, and Lepidus 6:26
An Open Letter to the Roman Senate 7:05
Power Struggles in the SPQR 8:07
The Punic Wars 9:47
Credits 11:44


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Why is there consensus around atoms existing, but not around if chocolate is good for you? In this episode of Crash Course Scientific Thinking, we’ll explore why there are still things we don’t know about topics we know a lot about, and why scientific consensus is the closest thing to “the truth.”

Introduction: Scientific Uncertainty 00:00
Scientific Consensus 0:33
Atomic Theory 1:28
Nutrition Science 4:21
Changing Consensus 6:48
Scientific Consensus in our Everyday Lives 7:26
Review & Credits 9:14

Sources: https://docs.google.com/document/d/1Kv2_mFsDxQURuFDxpflD45dy-pCxlqnM9iPSNYxigmQ/edit?tab=t.0#heading=h.vk5i2fgqyumq

***
Support us for $5/month on Patreon to keep Crash Course free for everyone forever! https://www.patreon.com/crashcourse
Or support us directly: https://complexly.com/support
Join our Crash Course email list to get the latest news and highlights: https://mailchi.mp/crashcourse/email
Get our special Crash Course Educators newsletter: http://eepurl.com/iBgMhY

Thanks to the following patrons for their generous monthly contributions that help keep Crash Course free for everyone forever:
NassauLinda, Chuck Smith, DexcilaDou, Martin G. Diller, Johnathan Williams, Allison Wood, Katrix , Jason Terpstra, Evan Nelson, Jennifer Wiggins-Lyndall, SpaceRangerWes, Dalton Williams, Chelsea S, Matthew Fredericksen, AThirstyPhilosopher ., Michael Maher, Mitch Gresko, Gina Mancuso, Roger Harms, Shruti S, Quinn Harden, Reed Spilmann, Brandon Thomas, Emily Beazley, Rie Ohta, oranjeez, UwU, Elizabeth LaBelle, Leah H., David Fanska, Andrew Woods, Kevin Knupp, Barbara Pettersen, Ken Davidian, Stephen Akuffo, Toni Miles, Steve Segreto, Kyle & Katherine Callahan, Laurel Stevens, Tanner Hedrick, Kristina D Knight, Samantha, Krystle Young, Scott Harrison, Alan Bridgeman, Breanna Bosso, Matt Curls, Liz Wdow, Jennifer Killen, Duncan W Moore IV, Sarah & Nathan Catchings, team dorsey, Bernardo Garza, Trevin Beattie, Pietro Gagliardi, John Lee, Eric Koslow, Indija-ka Siriwardena, Jason Rostoker, Siobhán, Ken Penttinen, Nathan Taylor, Barrett, Les Aker, ClareG, Rizwan Kassim, Constance Urist, Alex Hackman, Triad Terrace, Katie Dean, Jason Buster, Emily T, Stephen McCandless, Thomas, Joseph Ruf, Wai Jack Sin, Ian Dundore, Erminio Di Lodovico, Evol Hong, Tandy Ratliff, Caleb Weeks, Luke Sluder
__

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