Danika Bannasch, DVM, PhD returns to the podcast to talk about the Dalmatian Outcross Project. Danika's laboratory found the genetic mutation that was targeted in this outcross, and she had a front row seat to the project's path to acceptance by the AKC and the Dalmatian Club of America. She is also herself a past breeder of Dalmatians. Danika walks us through the genetic, social, and practical implications of high uric acid in Dalmatians, why the outcross was necessary, how it worked, and which populations with different mutations could be helped today by a similar approach (spoiler - one of them is the population of dogs in breeds with high frequency of the chondrodystrophy mutation that we discussed in the previous episode).