AI agents are no longer limited to automating routine tasks like customer support or report generation. Research labs and pharmaceutical companies are beginning to deploy teams of specialist AI agents capable of designing experiments, analyzing data, and proposing new hypotheses — in some cases producing results that outperform human experts. For data scientists and researchers, this raises urgent questions: Where do AI agents excel in scientific workflows today, and where do they fall short? How do you build an agent that can genuinely innovate rather than just replicate what's already been done? And what does it take to scale a single model into a fully functioning virtual research team?

James Zou is an Associate Professor of Biomedical Data Science, and by courtesy of Computer Science and Electrical Engineering, at Stanford University. He leads the Stanford AI for Science Lab and is affiliated with Together AI. His research focuses on building AI agents for scientific discovery and data science, making AI more reliable and statistically rigorous. He has received a Sloan Fellowship, NSF CAREER Award, two Chan-Zuckerberg Investigator Awards, and faculty awards from Google, Amazon, and Adobe.

In the episode, Richie and James explore how AI scientist agents are already outperforming human experts in scientific discovery, the Virtual Lab framework for building teams of specialist AI agents that conduct real research, teaching models to innovate not just imitate through a new training paradigm called "learning to discover," DS Gym for self-improving data science agents, scaling agentic systems from a single model to a Virtual Biotech with tens of thousands of agents, Einstein Arena as the first competition platform built exclusively for AI agents, converting scientific papers into agent-native MCPs through Paper to Agent, and much more.

Links Mentioned in the Show:

• Virtual Lab (Nature paper)

• Einstein Arena

• DS Gym

• Paper2Agent

• Together AI

• AlphaFold 2 / Nobel Prize 2024

• Connect with James

• AI-Native Course: Intro to AI for Work

• Related Episode: #358 How AI Agents Will Work While You Sleep | Ruslan Salakhutdinov

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Most organizations know AI matters, but few have turned that conviction into a written plan. Ambition and hope are everywhere; a clear roadmap tied to business strategy is rare. For teams on the ground, this gap shows up as scattered initiatives, tools nobody fully uses, and a lot of activity that never adds up to real value. So where do you actually start? How do you move from a long list of use cases to a focused plan you can execute? And who in the organization should own the job of turning AI into business results?

Charlene Li is a New York Times bestselling author and strategic advisor who has spent more than two decades helping leaders navigate disruptive change. She founded Altimeter Group, has advised 49 of the Fortune 100, and is the co-author of Winning with AI: The 90-Day Blueprint for Success (with Dr. Katia Walsh).

In the episode, Richie and Charlene explore how to get your organization AI-ready in 90 days, why you don't need a separate AI strategy, appointing an AI value owner, creating value beyond efficiency, building AI fluency, Goldilocks governance, why you should kill your AI pilots, and much more.

Links Mentioned in the Show:

• Winning with AI: The 90-Day Blueprint for Success
• Dr. Katia Walsh (co-author)
• Moderna
• Konecta
• IKEA
• Andrej Karpathy's LLM Wiki
• Connect with Charlene: LinkedIn
• AI-Native Course: Intro to AI for Work
• Related Episode: Our Data Trends & Predictions for 2026 with Jonathan Cornelissen & Martijn Theuwissen

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AI agents are starting to handle parts of the shopping journey that used to require human judgment — discovery, comparison, checkout. But behind every agent recommendation is a massive, invisible layer of data infrastructure. Product catalogs need to be structured, inventory synced in real time, pricing accurate, and quality signals clear. For data engineers and teams building at companies like Shopify, this shift means rethinking how data flows through systems and what "good enough" quality actually means. How do you ensure data is ready for AI? And how is this reshaping what data teams actually do?

Nell Thomas is the VP of Data at Shopify, where she leads a team of approximately 400–500 people across data infrastructure, ML platforms, data engineering, and data science. Her career spans multiple industries including social media (Facebook), e-commerce (Etsy), politics (Hillary for America, Democratic National Committee), and now commerce. She holds an A.B. in Psychology from Harvard University and an M.A. in History & Sociology of Science from the University of Pennsylvania.

In the episode, Richie and Nell explore agentic commerce and how AI agents are transforming shopping, the role of data in enabling AI-driven commerce, Shopify's Catalog and Universal Commerce Protocol, data quality requirements for agentic systems, how the data team function is evolving at Shopify, changing skill requirements for data professionals, and Nell's unconventional career path from politics to tech.

Links Mentioned in the Show:

- Agentic Commerce on Shopify

- Universal Commerce Protocol (UCP) vs Agentic Commerce Protocol (ACP)

- Shopify Catalog Documentation

- Agentic Storefronts — Shopify Sales Channel

- ChatGPT — OpenAI's Conversational AI

- How Shopify Built Data Infrastructure at Scale

Related

Scaling Data Quality in the Age of Generative AI

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Technical skills are being commoditized faster than ever. As AI takes on more of the work that used to define a junior knowledge worker, the things that once made someone valuable are becoming table stakes. What compounds in this environment is reputation — what colleagues, clients, and decision-makers think about you when your name comes up.

That puts new pressure on visibility. People doing great work in silence are increasingly the ones getting passed over for promotions and external opportunities. So how do you build a reputation without becoming an influencer? What does AI-era credibility actually look like? And how do you start small?

Dorie Clark teaches Executive Education at Columbia Business School and is the Wall Street Journal and USA Today bestselling author of The Long Game, Entrepreneurial You, Reinventing You, and Stand Out. She has been named four times as one of the Top 50 business thinkers in the world by Thinkers50, recognized as the #1 Communication Coach in the world by the Marshall Goldsmith Leading Global Coaches Awards, and is a frequent contributor to the Harvard Business Review.

In the episode, Richie and Dorie explore why AI fluency is the new Excel skill, tinkering with AI's jagged frontier, the security risks of agentic AI, what personal branding really means in an AI-disrupted job market, the recognized expert formula, the ladder strategy for credibility, networking with "no asks for a year," running better meetings, and much more.

Links Mentioned in the Show:

• The Jagged Frontier (HBS Working Paper)

• Agentic Misalignment: How LLMs could be insider threats (Anthropic)

• AI-powered coding tool wiped out a software company's database (Fortune)

• Reinventing You by Dorie Clark

• The Long Game by Dorie Clark

• Superteams by Ron Friedman

• Connect with Dorie on LinkedIn

• AI-Native Course: Intro to AI for Work

• Related Episode: #341 Our Data Trends & Predictions for 2026

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The role of the machine learning engineer is being rewritten in real time. AI coding assistants are absorbing parts of the day-to-day, planning and evaluation are eating up more of the week, and the lines between machine learning engineer, AI engineer, and data scientist are blurrier than ever. For anyone working in data and AI — or trying to break in — this shift changes what skills are worth investing in, what employers actually screen for, and how interviews are run. What's still worth learning? What does a competitive portfolio look like? And how do you stand out when a thousand applicants are using bots to apply?

Marina Wyss is a Senior Applied Scientist at Twitch (an Amazon company), where she builds production AI and machine learning systems across content understanding, recommendations, and forecasting. She came into the field from a non-traditional background — a political science undergrad and a Master's in social data science in Berlin — and has held machine learning roles at Coursera and a Berlin-based statistical consultancy along the way. Outside her day job, Marina runs a popular AI/ML YouTube channel and weekly newsletter, and coaches people transitioning into machine learning from non-traditional careers.

In this episode, Richie and Marina explore how AI is reshaping the machine learning engineer role, the shifting balance between coding and planning, why evaluation matters more than ever, the differences between ML engineer, AI engineer, and data scientist roles, how to break into the field from a non-technical background, what makes a strong portfolio project, the hiring process at big tech, how to prepare for technical interviews, networking strategies that actually work, what success looks like in your first few months on the job, and much more.

Links Mentioned in the Show

• Chip Huyen — AI Engineering (book)

• Andrew Codesmith on YouTube

• Phillip Choi on YouTube

• A Life Engineered on YouTube

• Keras

• LeetCode

• Connect with Marina: LinkedIn

• AI-Native Course: Intro to AI for Work

• Related Episode: How to Have a Career in Data Science in 2025 with Dawn Choo

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Every conversation about AI in data eventually arrives at the same question: which roles survive, and which ones get automated away? Generative AI can already draft SQL, build dashboards, and run exploratory analysis — but it still can't sit with a business stakeholder and untangle what "customer" actually means across five teams. For data professionals, that shifts the day-to-day from production work toward translation, modeling, and judgment. So which skills are worth doubling down on? Which roles are becoming central, and which are quietly disappearing? And what should anyone hiring — or being hired — be paying attention to right now?

Veronika Durgin is the VP of Data at Saks Global, where she leads data strategy across the luxury retail group. A full-stack data executive with more than two decades of experience spanning database administration, data engineering, platform architecture, data modeling, and analytics, Veronika is a Snowflake Data Superhero and a member of CDO Magazine's Global Editorial Board. She writes about data modeling, data culture, and data leadership on her Substack and Medium.

In the episode, Richie and Veronika explore the future of data careers under AI, why analytics engineering becomes the catch-all role, the skills and hiring shifts data leaders are making, centralized data with decentralized analytics, keeping enterprise data teams agile, conceptual data modeling as the unglamorous prerequisite to AI, semantic layers, agentic commerce, and much more.

Links Mentioned in the Show:

• Connect with Veronika: LinkedIn
• Veronika's Substack: Think. Solve. Repeat.
• dbt — referenced as the origin of "analytics engineering"
• Open Data Science Conference (ODSC) — Veronika's recent talk on data and company politics
• Amazon "two-way door" decisions — Bezos shareholder letter
• Jessica Talisman — Veronika's recommendation for knowledge graphs and ontologies
• Juan Sequeda — referenced on semantic layers and knowledge graphs
• Catalog & Cocktails podcast (hosted by Juan Sequeda)
• AI-Native Course: Intro to AI for Work
• Related Episode: Creating an AI-First Data Team with Bilal Zia, Head of Data Science & Analytics at Duolingo

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Most AI ethics conversations sound the same: be fair, be transparent, be accountable. The values are right, but in practice they don't get teams out of bed in the morning. Executives nod along, employees take the compliance training, and meanwhile real risks like hallucinations, cascading failures, and autonomous agents acting at scale slip through. So what shifts when teams stop chasing an ethical ideal and start naming the specific disasters they want to avoid? Who needs to be in the room to spot them? And what kind of training actually changes how people use AI day to day?

Reid Blackman is the founder and CEO of Virtue, an AI ethical risk consultancy, and the author of The Ethical Nightmare Challenge: How to Avoid the Worst of AI (2026) and Ethical Machines (HBR Press, 2022). A former philosophy professor at Colgate with a PhD from the University of Texas at Austin, he has designed responsible AI programs for organizations including Amazon, Etsy, Kraft Heinz, Merck, US Bank, and Nationwide, and has advised the FBI, NASA, the World Economic Forum, and the Canadian government on federal AI regulations. He also hosts the Ethical Machines podcast.

In the episode, Richie and Reid explore why responsible AI fails to motivate organizations, the biggest AI ethical nightmares facing companies today, the unique risks of agentic AI including cascading failures and emergent risks, the Ethical Nightmare Challenge framework, cross-functional ENC teams, training employees in plain language, scaling AI governance, measuring success by what you avoid, and much more.

Links Mentioned in the Show:

• The Ethical Nightmare Challenge by Reid Blackman

• Ethical Machines by Reid Blackman

• Ethical Machines podcast

• Claude Code

• Connect with Reid: LinkedIn

• AI-Native Course: Intro to AI for Work

• Related Episode: #350 How to Make Hard Choices in AI with Atay Kozlovski

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Valerie Tiberius is the Paul W. Frenzel Chair in Liberal Arts and Professor of Philosophy at the University of Minnesota. She is an expert in ethics, moral psychology, and well-being, and the author of five books including What Do You Want Out of Life? and the forthcoming Artificially Yours: Real Friendship in a World of Chatbots (Princeton University Press, May 2026). She previously served as President of the Central Division of the American Philosophical Association.

In the episode, Richie and Valerie explore the purpose of friendship and whether AI can replicate it, the benefits and risks of chatbot companions for loneliness, how sycophantic AI responses distort advice and self-perception, the dangers of companion chatbots for children's social development, designing ethical AI companions that promote human flourishing, the zone of proximal development as a framework for better AI tools, and much more.

Links Mentioned in the Show:

• Artificial Intimacy by Sherry Turkle
• Being You: A New Science of Consciousness by Anil Seth
• Liberation Day: Stories by George Saunders
• Hard Fork podcast (NYT)
• Connect with Valerie
• AI-Native Course: Intro to AI for Work
• Related Episode: #342 — "The Secrets to High AI Adoption" with Stefano Puntoni, Professor at Wharton

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Almost every AI agent demo lands in roughly the same place: it works most of the time, looks remarkable, and then fails in a way no one anticipated. Self-driving cars hit this wall a decade ago, and agents are running into it now. For data and AI teams, the question is no longer whether agents can complete a task — it's whether they can complete it reliably enough to remove the human reviewer. Which categories of work tolerate a 90% success rate? Which absolutely don't? And where should the next layer of guardrails sit?

Ruslan Salakhutdinov is a UPMC Professor of Computer Science at Carnegie Mellon University and one of Geoffrey Hinton's former PhD students. He has previously served as Director of AI Research at Apple and VP of Research in Generative AI at Meta. His research focuses on deep learning, reasoning, and AI agents.

In the episode, Richie and Russ explore the most exciting use cases of AI agents today, long horizon tasks, the credit assignment problem, multi-agent systems, designing reliable human-in-the-loop workflows, agent safety and guardrails, embodied and physical AI, lessons from self-driving cars, the difference between academia and industry, and much more.

Links Mentioned in the Show:

• Claude Code (Anthropic)

• Yutori

• Waymo

• Apple Project Titan

• DeepSeek-V3 Technical Report

• Kimi K2 Technical Report

• Connect with Ruslan: LinkedIn

• AI-Native Course: Intro to AI for Work

• Related Episode: AI Agents at Work: What Actually Breaks (and How to Fix It) with Danielle Crop

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The data field has changed shape faster than almost any other. The role that used to be a statistician became a data scientist, became an ML engineer, and is now morphing into AI engineer. Consulting firms are hiring fewer entry-level analysts and more vibe-coders who can ship AI systems to production. For data and AI professionals, this raises immediate questions. Which parts of the work are most exposed to automation, and which are not? Where should you invest your time? And which backgrounds are now producing the strongest hires, whether you are building a team or trying to join one?

Ben Zweig is the CEO and Co-Founder of Revelio Labs, where he leads the development of a universal HR database built on over a billion public employment profiles and more than 5 billion job postings. He holds a PhD in Economics from the CUNY Graduate Center and teaches Data Science and The Future of Work at NYU Stern. Before founding Revelio Labs, he managed Workforce Analytics projects in the IBM Chief Analytics Office and worked as a data scientist at an emerging-markets hedge fund. He is the author of Job Architecture: Building a Workforce Intelligence Taxonomy.

In the episode, Richie and Ben explore why hiring is a broken two-sided market, why jobs are bundles of tasks not skills, building universal taxonomies from billions of job postings, which data careers resist AI, advice for hiring data talent, when traditional NLP beats LLMs, and much more.

Links Mentioned in the Show:

• Ben's book — Job Architecture: Building a Workforce Intelligence Taxonomy
• Revelio Labs
• O*NET — the US government occupational taxonomy Ben critiques
• Baruch Lev — The End of Accounting
• Haskel & Westlake — Capitalism Without Capital
• Justified Posteriors podcast (Andrey Fradkin & Seth Benzell)
• Connect with Ben: LinkedIn
• AI-Native Course: Intro to AI for Work
• Related Episode: Our Data Trends & Predictions for 2026 with Jonathan Cornelissen & Martijn Theuwissen

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