This week on Death Clock, Brent speaks with journalist and author Nicole Karlis about the connection between altruism and longevity. Nicole, author of Your Brain on Altruism, shares research-backed insights into how acts of kindness, generosity, and volunteering can positively impact both mental and physical health. They discuss how altruism isn’t just about helping others – it also fosters a sense of purpose, strengthens community ties, and can even contribute to a longer, healthier life. Brent and Nicole explore the science behind these benefits, including studies showing that people who regularly give back experience lower stress levels, improved well-being, and even reduced risk of chronic diseases. Whether you’re looking for a new perspective on well-being or simply interested in the science of giving, this episode offers compelling reasons to integrate more acts of kindness into daily life. Hope you enjoy.

This week, Brent welcomes Dr. Diane Reidy-Lagunes, a clinical oncologist at Memorial Sloan Kettering Cancer Center, specializing in gastrointestinal cancers such as neuroendocrine, colorectal, and pancreas cancers. They discuss the cutting-edge landscape of cancer prevention and early detection, full-body scans, blood-based cancer screenings, and lifestyle interventions. Dr. Reidy-Lagunes goes in depth on the complexities of cancer biology, the role of genetic versus lifestyle factors, and the emerging field of microbiome research in understanding cancer risk. This episode is an essential primer for anyone looking to better understand cancer prevention and early detection. Hope you enjoy.

You can listen to Memorial Sloan Kettering’s official podcast, Cancer Straight Talk, hosted by Dr. Diane Reidy-Lagunes, wherever you get your podcasts.

In this episode of Death Clock, Brent talks with Dr. Thomas Seyfried, an impassioned biologist and leading voice in the metabolic theory of cancer. Seyfried argues that the origins of cancer lie not in mutations, but in dysfunctional mitochondria, and that treating cancer as a metabolic disease opens the door to radically different therapies. They explore the promise and pitfalls of ketogenic diets, fasting, and metabolic interventions, and challenge conventional thinking on everything from chemo to cancer screening. Hope you enjoy.

After a routine heart scan reveals a potentially life-threatening anomaly, host Brent Franson speaks with return guest Dr. Todd Dorfman and his cardiologist Dr. Jamie Doucet to unpack what it means and what to do next. Their conversation broadens to the topics of anomalous coronary arteries, the role of advanced heart scans in preventative care and the gray areas of modern cardiology. They unpack the promise and pitfalls of early detection, the tradeoffs between lifestyle and surgery and how to navigate scary data with humility, evidence and expert guidance. It’s a fascinating episode, hope you enjoy. 

In this episode, Brant converses with Dr. Todd Dorfman, a Boulder-based concierge physician, to explore the future of preventative health care. They discuss the differences between concierge and traditional primary care, including why structural and economic constraints prevent most doctors from practicing truly individualized medicine. Dr. Dorfman breaks down powerful diagnostic tools like CT coronary angiography and full-body MRI, explaining the benefits and limitations of early screening for heart disease and cancer. They also cover emerging longevity treatments like metformin and GLP-1 agonists, and how Dr. Dorfman tailors these for patients long before they’re in crisis. It’s a compelling look at what personalized medicine can really do when it’s practiced on your own terms. Hope you enjoy.

In this episode of Death Clock, Brent speaks with Dr. Steve Messier, a leading expert on osteoarthritis and biomechanics, about the myths and realities of joint health. They explore how weight, injury, gender, and exercise all factor into knee pain and degradation, and why “wear and tear” is an oversimplified diagnosis. Dr. Messier shares practical, research-backed advice on how to care for your joints. He also highlights surprising findings about the benefits of strength training, the limits of supplements, and how lifestyle may be the most powerful intervention of all. Hope you enjoy.

In this episode of Death Clock, Brent speaks with Dr. Connie Weaver, a leading nutrition and bone health researcher, to explore how our bones grow, weaken, and can be protected throughout life. From calcium-rich diets and weight-bearing exercise in childhood to the overlooked risks of osteoporosis in men, Dr. Weaver shares scientific findings and public health insights that challenge the way we think about aging, hormones, and prevention. She’s a great guest, hope you enjoy.

On today’s episode of Death Clock, host Brent Franson speaks with Dr. Aric Prather, a professor at UCSF, clinical psychologist, and author of The Sleep Prescription: Seven Days to Unlocking Your Best Rest. Dr. Prather unpacks the critical relationship between sleep and stress, explaining how poor sleep increases stress sensitivity and creates a vicious cycle that can degrade long-term health. They also discuss the latest in sleep research, including wearables like the Oura Ring and Eight Sleep, and how these tools can help—or hinder—our understanding of rest. They also explore the role of diet, nighttime routines, and the often-overlooked psychological aspect of sleep perception. Whether you struggle with insomnia, want to optimize your rest, or are simply curious about the science of sleep and longevity, this episode provides helpful insights from one of the leading experts in the field. Hope you enjoy.

In this episode of Death Clock, host Brent Franson welcomes back Dr. Frank Lipman, a pioneer in functional and longevity medicine. With decades of experience, Dr. Lipman shares his insights on the fundamentals of longevity, emphasizing the critical role of diet, exercise, sleep, and stress management as the foundation for a longer, healthier life. The conversation explores the latest advancements in longevity science, from biomarker testing and supplements to cutting-edge therapies like peptides, hormone optimization, and hyperbaric oxygen treatment. 

Their discussion also covers controversial topics, including full-body scans, the accuracy of various health screenings, and the efficacy of specific vaccines. Dr. Lipman shares his candid thoughts on the benefits and limitations of emerging trends, offering practical advice on how to approach health optimization without getting lost in hype. Whether you’re curious about the latest in anti-aging research or looking for practical steps to improve your long-term health, this episode provides an insightful perspective from one of the field’s leading voices. Hope you enjoy.

In this episode of Death Clock, host Brant Franson speaks with Dr. Anne Marie McCarthy, a cancer epidemiologist from the University of Pennsylvania, to unravel the complexities of breast cancer prevention and screening. They explore the role of genetics, particularly BRCA mutations, and how family history can influence screening strategies. Dr. McCarthy shares insights into the nuanced decisions around genetic counseling, the limitations of over-the-counter tests, and why population-wide genetic screening is still a topic of ongoing debate. They also discuss broader issues like the psychological and economic costs of false positives, overdiagnosis, and overtreatment. From lifestyle factors to systemic constraints in healthcare access, this episode offers a comprehensive look at what it means to be proactive when it comes to breast cancer risk. Hope you enjoy.