Is religious experience merely a function of brain chemistry, or does neuroscience reveal something deeper about human spirituality? Matthew Alper returns with his controversial theories about the biological basis of religious belief, armed with new evidence from recent genetic research. As Alper notes, recent media attention surrounding the discovery of a "God gene" has provided substantial support for his arguments about the neurological foundations of spiritual experience. The discussion explores how human brain cells function in religious contexts, examining research that suggests spiritual experiences may be hardwired into our neural architecture. Alper's theories have consistently provoked intense reactions from audiences, challenging fundamental assumptions about the nature of faith, consciousness, and divine experience. The conversation covers cutting-edge neuroscience research that maps the brain regions activated during religious experiences, raising profound questions about free will, spiritual authenticity, and the relationship between mind and spirit. This thought-provoking episode forces listeners to grapple with uncomfortable questions about whether their deepest spiritual convictions might be products of evolutionary biology rather than divine revelation.