Welcome to the December 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the December 2024 issue of Diabetes. 

0:55 In celebrating the one-year anniversary of DiabetesBio, our hosts highlight a few of their favorite articles from the last year. These include: 

• Ueki et al. Establishment of Pancreatic β-Cell–Specific Gene Knockout System Based on CRISPR-Cas9 Technology With AAV8-Mediated gRNA Delivery doi.org/10.2337/db23-0445
• Bruce et al. The Effect of Small Increases in Blood Glucose on Insulin Secretion and Endogenous Glucose Production in Humans doi.org/10.2337/db24-0388
• Furber et al. GIPR Agonism Enhances TZD-Induced Insulin Sensitivity in Obese IR Mice doi.org/10.2337/db23-0172
• Greenbaum et al. Evolving Concepts in Pathophysiology, Screening, and Prevention of Type 1 Diabetes: Report of Diabetes Mellitus Interagency Coordinating Committee Workshop doi.org/10.2337/dbi24-0020
• Ramos et al. Role of Cardiorespiratory Fitness and Mitochondrial Oxidative Capacity in Reduced Walk Speed of Older Adults With Diabetes doi.org/10.2337/db23-0827
• Bonifazi et al. Development of Novel Tools for Dissection of Central Versus Peripheral Dopamine D2-Like Receptor Signaling in Dysglycemia doi.org/10.2337/db24-0175

6:15 Darleen is joined by Lukas Stilgenbauer of the Department of Biological Sciences at Wayne State University in Detroit, Michigan, as well as Mariana Sadagurski, associate professor in the Institute of Environmental Health Sciences and Integrative Biosciences Center at Wayne State University.  They discuss their article “Microglia Mediate Metabolic Dysfunction From Common Air Pollutants Through NF-κB Signaling.” This article is available for free at doi.org/10.2337/db24-0110

33:45 Kirk and Kevin dive into the December issue’s Paper of the Month, “Effect of Weight Loss on Skeletal Muscle Bioactive Lipids in People With Obesity and Type 2 Diabetes.” They’re joined by lead author Max Petersen, an instructor at the Division of Endocrinology, Metabolism, & Lipid Research at Washington University School of Medicine in St. Louis, Missouri. The article is available for free at doi.org/10.2337/db24-0083.

47:20 Finally, this month’s edition of Sweet Talk focuses on work funded by the American Diabetes Association’s Pathway to Stop Diabetes initiative. Kathleen Alanna Page, Associate Professor of Medicine at the University of Southern California’s Keck School of Medicine, and Jasmin Alves, a postdoctoral research fellow with Page, stop by to discuss Page’s study, “Neurodevelopmental Pathways to Obesity and Type 2 Diabetes: Insights From Prenatal Exposure to Maternal Obesity and Gestational Diabetes Mellitus: A Report on Research Supported by Pathway to Stop Diabetes.” The article is available at doi.org/10.2337/dbi24-0012

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

Welcome to the November 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the November 2024 issue of Diabetes. 

3:45 After a quick rundown of our hosts' Halloween plans, this month’s episode begins with a special offer from the ADA for new and renewing members: a 15% discount on a 1- or 2-year membership. Go to professional.diabetes.org/membership, create your account, fill out the application, and use the discount code ‘FALL24’ at checkout. Act fast because this offer expires November 30, 2024! 

5:00 Darleen and Kirk speak with Dr. Nicholas Maxwell, postdoctoral fellow at Duke University School of Medicine, and Claudia Grillo, a research associate professor in the Department of Pharmacology, Physiology, and Neuroscience at the University of Southern Carolina School of Medicine in Columbia. They are lead author and corresponding author, respectively, of the article “Leptin Activation of Dorsal Raphe Neurons Inhibits Feeding Behavior.” This article is available for free at doi.org/10.2337/db24-0207. 

27:05 Our hosts discuss the November issue’s Paper of the Month, “Deciphering the Connection Between Microvascular Damage and Neurodegeneration in Early Diabetic Retinopathy.” They’re joined by senior author, Dr. Marcus Fruttiger, Professor of Experimental Ophthalmology at the Institue of Ophthalmology, University College, London. This study is available at doi.org/10.2337/db24-0107. 

50:25 Finally, in honor of World Diabetes Awareness Day on November 14, as well as National Diabetes Month, this month’s Sweet Talk segment features Dr. Giles Yeo, a geneticist and obesity researcher from the University of Cambridge. Dr. Yeo discusses how genetic variations contribute to obesity, appetite control, and metabolic health. 

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

Welcome to the October 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the October 2024 issue of Diabetes and interview a Pathway to Stop Diabetes award winner. 

4:05 This month’s episode begins with a special offer from the ADA for new and renewing members: a 15% discount on a 1- or 2-year membership. Go to professional.diabetes.org/membership, create your account, fill out the application, and use the discount code ‘FALL24’ at checkout. Act fast because this offer expires November 30, 2024! 

5:15 Darleen and Kirk speak with Dr. Magnus Grøndahl, faculty of Health and Medical Sciences and doctor of medicine at University of Copenhagen, about his paper, “Glucagon Clearance Is Decreased in Chronic Kidney Disease but Preserved in Liver Cirrhosis.” This article is available for free at doi.org/10.2337/db24-0305. 

19:05 Our hosts discuss a featured article entitled “Cryopreservation of Stem Cell–Derived β-Like Cells Enriches for Insulin-Producing Cells With Improved Function.” They’re joined by the study’s lead author, Dr. Jessie Barra, and corresponding author—as well as Barra’s mentor—Dr. Holger Russ. This study is available at doi.org/10.2337/db24-0346. 

35:00 Finally, just in time for National Vision Awareness Month, a Sweet Talk segment first: a discussion on the important topic of diabetic retinopathy. Dr. Siddharth Sunilkumar and Dr. Michael Dennis discuss their Perspectives article, “REDD1 Is a Promising Therapeutic Target to Combat the Development of Diabetes Complications: A Report on Research Supported by Pathway to Stop Diabetes,” funded by the ADA Pathway to Stop Diabetes Initiator Award, which was given to Dr. Dennis in 2014. This article is freely accessible at doi.org/10.2337/dbi24-0013. 

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

Welcome to the September 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the September 2024 issue of Diabetes and interview a Pathway to Stop Diabetes award winner. 

4:20: Darleen and Kirk are joined by Jose A. Ortiz and Hsun Teresa Ku, first and last authors of “Trefoil Factor 2 Expressed by the Murine Pancreatic Acinar Cells Is Required for the Development of Islets and for β-Cell Function During Aging.” This article is an editor-selected feature article and is freely accessible at https://doi.org/10.2337/db23-0490. 

25:07: Kirk and Darleen talk to Adrian Vella, last author of “The Longitudinal Effect of Diabetes-Associated Variation in TCF7L2 on Islet Function in Humans.” This article is also an editor-selected feature article and is freely accessible at https://doi.org/10.2337/db24-0192. 

50:21: In this month’s Sweet Talk segment, Kevin chats with Matthew J. Webber, a 2019 Pathway to Stop Diabetes Accelerator Award winner, about his research on materials that can sense and respond to changing glucose. 

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

Welcome to a very special episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. While this podcast usually focuses on the research published in Diabetes, this unique episode focuses on the incredible scholarly content of the 84th Scientific Sessions, which took place 21–24 June in Orlando, FL. Alice Cheng, MD, FRCPC, co-host of Diabetes Care “On Air,” acted as emcee for a panel discussion with Michael Rickels, MD, MS, her co-host on Diabetes Care “On Air”; Kirk Habegger, PhD, Darleen Sandoval, PhD, and Kevin Williams, PhD, the co-hosts of DiabetesBio; and Neil Skolnik, MD, co-host of Diabetes Core Update and Diabetes Day by Day. This episode is being released on three of our professional podcasts: Diabetes Care “On Air,” DiabetesBio, and Diabetes Core Update. This special episode is supported by an independent educational grant from Bayer.

This wide-ranging discussion begins with introductions and brief descriptions of the various podcasts, and then the panelists highlight their favorite sessions and events from the 84th Scientific Sessions—the new, high-impact research presented at the meeting, implications for future research, and clinical considerations and take-aways—across the “bench-to-bedside” spectrum of biomedical research, clinical research, and treatment advances. (Please note that anyone who registered for the event can still access the recorded content at ada2024.org until August 26.)  

Correction: •Dr. Carmella Evans-Molina is from the Indiana University School of Medicine •Dr. Lou Philipson is from the University of Chicago

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

Welcome to the August 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the August 2024 issue of Diabetes. 

2:39: Darleen and Kirk are joined by Dr. Inbal Caspi and Dr. Danwei Huangfu, lead author and corresponding author, respectively, of the August Paper of the Month, entitled “Glucose Transporters Are Key Components of the Human Glucostat.” This article is an editor-selected feature article and is freely accessible at https://doi.org/10.2337/db23-0508. 

27:30: Kirk and Darleen host Dr. Deepthi P. Mallela, co-lead author of “Comprehensive Clinical and Genetic Analyses of Circulating Bile Acids and Their Associations With Diabetes and Its Indices.” This article is an editor-selected feature article and is freely accessible at https://doi.org/10.2337/db23-0676.

50:21: In this month’s Sweet Talk segment, Kevin and Kirk engage in a scintillating discussion with Dr. Bernard Thorens and Dr. David J. Hodson, coauthors of a recent “Classics in Diabetes” feature, named “Building the Glucagon-Like Peptide-1 Receptor Brick by Brick: Revisiting a 1993 Diabetes Classic by Thorens et al.” This article is an editor-selected feature article and is freely accessible at https://doi.org/10.2337/dbi24-0025. The original “Classics” article is freely accessible at https://doi.org/10.2337/diab.42.11.1678. 

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

Welcome to the July 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the July 2024 issue of Diabetes. 

4:31: Darleen and Kirk are joined by Dr. Jordan J. Wright, first author of the Paper of the Month, entitled “Exocrine Pancreas in Type 1 and Type 2 Diabetes: Different Patterns of Fibrosis, Metaplasia, Angiopathy, and Adiposity.” This article is an editor-selected feature article and is freely accessible at https://doi.org/10.2337/db23-0009. 

17:23: Kirk and Darleen then chat with Dr. Lisa Smeehuijzen, first author of the article “Immunometabolic Signatures of Circulating Monocytes in Humans With Obesity and Insulin Resistance.” This article is an editor-selected feature article and is freely accessible at https://doi.org/10.2337/db23-0970.

20:26: In a very special Sweet Talk segment, Kevin is joined by cohosts Darleen and Kirk for an interview with Dr. Rury R. Holman, the winner of the 2024 Banting Medal for Scientific Achievement. More details about this award can be found at https://professional.diabetes.org/awards/banting-medal-scientific-achievement-award.     

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

Welcome to the June 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the June 2024 issue of Diabetes. 

2:27: Darleen and Kirk are joined by Dr. Ralph A. DeFronzo, senior author of the article “Effect of Dapagliflozin on Renal and Hepatic Glucose Kinetics in T2D and NGT Subjects.” This article is freely accessible at https://doi.org/10.2337/db23-0457.

20:26: In this month’s Sweet Talk segment, Kevin and Kirk highlight this month’s Point-Counterpoint feature on whether a new model is needed on the regulation of β-cell KATP channels in glucose metabolism. First, they talk to Drs. Matthew J. Merrins and Richard G. Kibbey, authors of the Counterpoint, titled “Glucose Regulation of β-Cell KATP Channels: It Is Time for a New Model!” This article is freely accessible at https://doi.org/10.2337/dbi23-0032. 

35:00: Kevin next is joined by Drs. Guy A. Rutter and Ian R. Sweet, authors of the Point article, titled “Glucose Regulation of β-Cell KATP Channels: Is a New Model Needed?” This article is freely accessible at https://doi.org/10.2337/dbi23-0031.   

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

Welcome to the May 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the May 2024 issue of Diabetes. 

5:06: Darleen and Kirk are joined by Drs. Devi Kasinathan, Zheng Guo, and Dax Fu, authors the May Paper of the Month, “Cell-Surface ZnT8 Antibody Prevents and Reverses Autoimmune Diabetes in Mice.” This article can be freely accessed at https://doi.org/10.2337/db23-0568.

20:14: Next, Kirk and Darleen highlight one of the ADA’s membership engagement groups, the Women’s Interprofessional Network of the ADA (WIN ADA), by chatting with Drs. Jennifer Lee and Rebecca Scalzo, the current cochairs of WIN ADA. They discuss the history and growth of WIN ADA, which is a members-only network for female clinicians, scientists, educators, and other health professionals in diabetes. Learn more about WIN ADA, including how to join, at https://professional.diabetes.org/membership/win-ada.

36:45: For the Sweet Talk segment, Kevin is joined by Drs. Olga T. Gupta and Rana K. Gupta, authors of May’s “Classics in Diabetes” article. The classic article they focus on is 1985’s “The Influence of Body Fat Distribution on the Incidence of Diabetes Mellitus: 13.5 Years of Follow-up of the Participants in the Study of Men Born in 1913,” by Ohlson et al. Kevin and his guests discuss the evolving concepts of regional adiposity and diabetes and other chronic disorders. Their “Classics” article is freely available at https://doi.org/10.2337/dbi24-0021, and the 1985 classic by Ohlson et al. can be found at https://doi.org/10.2337/diab.34.10.1055.   

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

Welcome to the April 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the April 2024 issue of Diabetes. 

2:55: To kick things off, Darleen and Kirk are joined by Dr. Sebastian Kalamajski (Lund University), senior author of “Human Genetic Variation at rs10071329 Correlates With Adiposity-Related Traits, Modulates PPARGC1B Expression, and Alters Brown Adipocyte Function.” This article can be freely accessed at https://doi.org/10.2337/db23-0531.

15:16: Darleen and Kirk chat with Dr. Yuval Dor (The Hebrew University of Jerusalem), senior author of “DNA Methylation–Based Assessment of Cell Composition in Human Pancreas and Islets.” This study can be freely accessed at https://doi.org/10.2337/db23-0704.

42:50: Darleen introduces a very special guest for this month’s Sweet Talk, Dr. Carmella Evans-Molina. She is the director of the Center for Diabetes and Metabolic Diseases at Indiana University School of Medicine, and she was awarded the 2023 Outstanding Scientific Achievement Award by the American Diabetes Association. Darleen and Kevin raise many topics in this conversation with Dr. Evans-Molina, from her focus on the role of calcium in regulating insulin secretion to the importance of serendipity and collaboration in scientific research to her recent hobby of learning to play the piano. 

To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!