Since the start of her tenure in July 2023, Dr. Mandy Cohen, Director of the U.S. Centers for Disease Control and Prevention (CDC), has pursued several reforms intended to make CDC a stronger, nimbler agency better able to protect Americans from domestic and global public health threats and rebuild trust. She is joined in conversation with former Senator Richard Burr, Co-Chair of the CSIS Bipartisan Alliance for Global Health Security and Principal Policy Advisor and Chair, Health Policy Strategic Consulting Practice, DLA Piper, and J. Stephen Morrison, CSIS Senior Vice President and Director, Global Health Policy Center. They discuss the agency’s achievements, what has worked and not worked, the core challenges that persist, and how to best position the agency to sustain progress in 2025.