Dr. GPCR Podcast

Dr. Sudarshan Rajagopal obtained his B.S. in Chemistry from The University of Chicago in 1998. He subsequently enrolled in the Medical Scientist Training Program at The University of Chicago. During his doctoral work in the lab of Prof. Keith Moffat, he studied the structural mechanisms of bacterial photoreceptors using time-resolved Laue crystallography. He was awarded his Ph.D. in 2004 and his MD in 2006. He then joined the Internal Medicine Residency training program at Duke University Medical Center. During his Cardiology fellowship, he trained in the lab of Dr. Robert J. Lefkowitz, where his research focused on biased agonism, with the development of approaches to quantify ligand bias and the identification of beta-arrestin-biased receptors.

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We aspire to provide opportunities to connect, share, form trusting partnerships, grow, and thrive together.

Fill out the Ecosystem waitlist form today to be the first to explore our brand new and improved space!

For more details, visit our website http://www.DrGPCR.com/Ecosystem/.

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Are you a #GPCR professional?

- Register to become a Virtual Cafe speaker

http://www.drgpcr.com/virtual-cafe/

-   Subscribe to our Monthly Newsletter

http://www.drgpcr.com/newsletter/

-   Listen and subscribe to #DrGPCR Podcasts

http://www.drgpcr.com/podcast/

-   Support #DrGPCR Ecosystem with your Donation.

http://www.drgpcr.com/sponsors/

-   Reserve your spots for the next #DrGPCR Virtual Cafe

http://www.drgpcr.com/virtual-cafe/

-   Watch recorded #DRGPCR Virtual Cafe presentations:

https://www.youtube.com/channel/UCJvKL3smMEEXBulKdgT_yCw

-   Share your feedback with us:

http://w

To read the full #Newsletter click here:

https://www.drgpcr.com/march-2022/

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Imagine a world in which the vast majority of us are healthy.

The #DrGPCR Ecosystem is all about dynamic interactions between us who are working towards exploiting the druggability of #GPCR's. We aspire to provide opportunities to connect, share, form trusting partnerships, grow, and thrive together.

To build our #GPCR Ecosystem, we created various enabling outlets.

For more details, visit our website http://www.DrGPCR.com/Ecosystem/.

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About Dylan Eiger

Dylan Eiger is currently an MD/Ph.D. student at Duke University School of Medicine. He received his B.S. in Chemistry from Duke University in 2016 where he worked in the lab of Dr. Stephen Craig and studied polymer chemistry and material science.

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We aspire to provide opportunities to connect, share, form trusting partnerships, grow, and thrive together.

Fill out the Ecosystem waitlist form today to be the first to explore our brand new and improved space!

For more details, visit our website http://www.DrGPCR.com/Ecosystem/.

-------------------------------------------

Are you a #GPCR professional?

- Register to become a Virtual Cafe speaker

http://www.drgpcr.com/virtual-cafe/

-   Subscribe to our Monthly Newsletter

http://www.drgpcr.com/newsletter/

-   Listen and subscribe to #DrGPCR Podcasts

http://www.drgpcr.com/podcast/

-   Support #DrGPCR Ecosystem with your Donation.

http://www.drgpcr.com/sponsors/

-   Reserve your spots for the next #DrGPCR Virtual Cafe

http://www.drgpcr.com/virtual-cafe/

-   Watch recorded #DRGPCR Virtual Cafe presentations:

https://www.youtube.com/channel/UCJvKL3smMEEXBulKdgT_yCw

-   Share your feedback with us:

http://www.drgpcr.com/audience-survey/

Dr. Khaled Abdelrahman graduated in 2006 with a BSc in Pharmaceutical Sciences from Alexandria University (Egypt) followed by MSc in Pharmacology in the same university that was conferred in 2009. He joined the laboratory of Dr. William Cole at the University of Calgary in 2010 for his Ph.D. where he studied the molecular basis underlying altered cerebrovascular function and blood flow in type 2 diabetes. In 2015, He joined Dr. Stephen Ferguson’s laboratory in the Departments of Cellular & Molecular Medicine and Neuroscience at the University of Ottawa as a Postdoctoral Fellow to explore novel G protein-coupled receptor (GPCR) candidates that can be targeted pharmacologically to slow neurodegeneration. He has been also studying what aspects of GPCR signaling are regulated in a sex-selective manner and how this can influence drug discovery in the area of neurodegenerative diseases.

Imagine a world in which the vast majority of us are healthy.

The #DrGPCR Ecosystem is all about dynamic interactions between us who are working towards exploiting the druggability of #GPCRs. We aspire to provide opportunities to connect, share, form trusting partnerships, grow, and thrive together.

To build our #GPCR Ecosystem, we created various enabling outlets.

For more details, visit our website http://www.DrGPCR.com/Ecosystem/.

-------------------------------------------

Are you a #GPCR professional?

- Register to become a Virtual Cafe speaker

http://www.drgpcr.com/virtual-cafe/

-   Subscribe to our Monthly Newsletter

http://www.drgpcr.com/newsletter/

-   Listen and subscribe to #DrGPCR Podcasts

http://www.drgpcr.com/podcast/

-   Support #DrGPCR Ecosystem with your Donation.

http://www.drgpcr.com/sponsors/

-   Reserve your spots for the next #DrGPCR Virtual Cafe

http://www.drgpcr.com/virtual-cafe/

-   Watch recorded #DRGPCR Virtual Cafe presentations:

https://www.youtube.com/channel/UCJvKL3smMEEXBulKdgT_yCw

- Bring in a #GPCR Consultant

http://www.drgpcr.com/consulting/

-   Share your feedback with us:

http://www.drgpcr.com/audience-survey/

-   Become a #DrGPCR Ecosystem Member

http://www.drgpcr.com/membership/

To read the full #Newsletter click here:

http://www.drgpcr.com/february-2022/

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Imagine a world in which the vast majority of us are healthy.

The #DrGPCR Ecosystem is all about dynamic interactions between us who are working towards exploiting the druggability of #GPCR's. We aspire to provide opportunities to connect, share, form trusting partnerships, grow, and thrive together.

To build our #GPCR Ecosystem, we created various enabling outlets.

For more details, visit our website http://www.DrGPCR.com/Ecosystem/.

For more details, visit #DrGPCR Episode #62 page 

https://www.drgpcr.com/episode-62-with-dr-sai-prasad-pydi/ 

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About Dr. Sai Prasad Pydi   

Dr. Sai Prasad Pydi obtained his Ph.D. from the University of Manitoba – Canada, where he was introduced to G protein-coupled receptors (GPCRs) by Prof. Prashen Chelikani. His doctoral research focused on the structural and functional characterization of bitter taste receptors (T2Rs). In 2014, Dr. Pydi joined Dr. Jurgen Wess’s lab at the National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) - NIH, USA as a postdoctoral fellow and trained on understanding the physiological role of GPCR signaling and beta-arrestins in diabetes and obesity. In February 2021, Dr. Pydi joined BSBE department at IIT-Kanpur. The main target of Dr. Pydi's laboratory is to develop GPCR-based drugs for the treatment of obesity and Type 2 Diabetes (T2D) by exploring metabolically important signaling pathways in immune cells and insulin-sensitive tissues (liver, pancreas, skeletal muscle, adipose tissue, and brain). His laboratory uses knock-out and transgenic mouse models, along with different cell culture systems, to understand the role of immune cell GPCRs and their cross-talk with other insulin-sensitive tissues regulating glucose and lipid metabolism. 

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Dr. Sai Prasad Pydi on the web   

Molecular Metabolism & Cell Signaling Laboratory 

https://www.mmcsliitk.in/ 

Website 

https://www.iitk.ac.in/bsbe/sai-prasad-pydi 

Twitter 

https://twitter.com/saip_pydi 

Research Gate 

https://www.researchgate.net/profile/Sai-Prasad-Pydi 

PubMed 

https://pubmed.ncbi.nlm.nih.gov/?term=pydi%20SP 

Google Scholar 

https://scholar.google.com/citations?user=VLWGR5gAAAAJ&hl=en

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Imagine a world in which the vast majority of us are healthy.

The #DrGPCR Ecosystem is all about dynamic interactions between us who are working towards exploiting the druggability of #GPCR's. We aspire to provide opportunities to connect, share, form trusting partnerships, grow, and thrive together.

To build our #GPCR Ecosystem, we created various enabling outlets.

For more details, visit our website http://www.DrGPCR.com/Ecosystem/.

-------------------------------------------

Are you a #GPCR professional?

- Register to become a Virtual Cafe speaker

http://www.drgpcr.com/virtual-cafe/

-   Subscribe to our Monthly Newsletter

http://www.drgpcr.com/newsletter/

-   Listen and subscribe to #DrGPCR Podcasts

http://www.drgpcr.com/podcast/

-   Support #DrGPCR Ecosystem with your Donation.

http://www.drgpcr.com/sponsors/

-   Reserve your spots for the next #DrGPCR Virtual Cafe

http://www.drgpcr.com/virtual-cafe/

-   Watch recorded #DRGPCR Virtual Cafe presentations:

https://www.youtube.com/channel/UCJvKL3smMEEXBulKdgT_yCw

- Bring in a #GPCR Consultant

http://www.drgpcr.com/consulting/

About Dr. Marta Filizola

Dr. Marta Filizola is the Sharon & Frederick A. Klingenstein-Nathan G. Kase, MD Professor in the Departments of Pharmacological Sciences, Neuroscience, and Artificial Intelligence and Human Health, as well as the Dean of The Graduate School of Biomedical Sciences at the Icahn School of Medicine at Mount Sinai, in New York, USA. The overall goal of her research program is to obtain rigorous mechanistic insights into the structure, dynamics, and function of important classes of membrane proteins and prominent drug targets, including G protein-coupled receptors (GPCRs), transporters, channels, and 3 integrins. To this end, her lab uses several computational structural biology tools and rational drug design approaches, ranging from molecular modeling, bioinformatics, cheminformatics, molecular dynamics simulations, free-energy perturbations, machine learning, etc. A native of Italy, she received her Bachelor’s and Master’s degrees in Chemistry from the University Federico II in Naples. She pursued a Ph.D. in Computational Chemistry at the Second University of Naples and a postdoctorate in Computational Biophysics at the Molecular Research Institute in California, USA.

Imagine a world in which the vast majority of us are healthy.

The #DrGPCR Ecosystem is all about dynamic interactions between us who are working towards exploiting the druggability of #GPCR's. We aspire to provide opportunities to connect, share, form trusting partnerships, grow, and thrive together.

To build our #GPCR Ecosystem, we created various enabling outlets.

For more details, visit our website http://www.DrGPCR.com/Ecosystem/.

-------------------------------------------

Are you a #GPCR professional?

- Register to become a Virtual Cafe speaker

http://www.drgpcr.com/virtual-cafe/

-   Subscribe to our Monthly Newsletter

http://www.drgpcr.com/newsletter/

-   Listen and subscribe to #DrGPCR Podcasts

http://www.drgpcr.com/podcast/

-   Support #DrGPCR Ecosystem with your Donation.

http://www.drgpcr.com/sponsors/

-   Reserve your spots for the next #DrGPCR Virtual Cafe

http://www.drgpcr.com/virtual-cafe/

-   Watch recorded #DRGPCR Virtual Cafe presentations:

https://www.youtube.com/channel/UCJvKL3smMEEXBulKdgT_yCw

- Bring in a #GPCR Consultant

http://www.drgpcr.com/consulting/

-   Share your feedback with us:

http://www.drgpcr.com/audience-survey/

-   Become a #DrGPCR Ecosystem Member

http://www.drgpcr.com/membership/

For more details, visit #DrGPCR Podcast Episode #60 page

https://www.drgpcr.com/episode-60-with-dr-josephine-pina-cardarelli/

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About Dr. Josephine (Pina) Cardarelli  

Dr. Pina Cardarelli, CSO for GPCR Therapeutics Inc., based in South Korea, has recently been named President of GPCR Therapeutics, USA, a newly incorporated Biotechnology company in the Bay Area. The company’s mission is to discover and develop highly effective cancer therapeutics by targeting heteromers of G protein-coupled receptors (GPCR). Burixafor, their most advanced clinical candidate, will be in Phase II clinical trial next year. Additionally, they have a library of target GPCR heteromers for Oncology. Dr. Cardarelli heads the team of talented researchers that will be expanding at the US site.  

Dr. Cardarelli is a drug development leader with extensive experience driving drug discovery teams in bringing biologics to clinical proof of concepts. She has expertise in cell biology, pharmacology, translational medicine, oncology, immuno-oncology, immunology, and clinical development. Previously, she held the position of Vice President of Cell Biology & Pharmacology, at Bristol-Myers Squibb. She was an integral contributor to two therapeutics that are FDA approved, Yervoy and Opdivo. She was a participant in numerous due diligence (anti-CXCL8 mAb) and has managed external collaborations and alliances. Prior to this, she held the position of Vice President, at Medarex, Inc. While at BMS and Medarex, she led programs from target ID to clinical development that included, CXCL10 (Eldelumab), CXCR4 (Ulocuplumab), CD30, CD19, Fucosyl GM-1, & mesothelin-ADC, Glypican-3-ADC, CD70-ADC.

She oversaw early discovery programs IL-23 p19 and IL23 p19/IL-17 bispecifics. At Medarex, she initiated and identified the lead mAb for the type I interferon-alpha receptor project, licensed to AstraZeneca (Saphnelo™ Anifrolumab) that has just received FDA approval for systemic lupus erythematosus. She has extensive experience working with Biologics, and Antibody Drug Conjugates as well as experience in IND fillings, IB updates, and responding to FDA inquiries. She is an inventor on 39 issued U.S. patents including anti-PD-1 patents, 22 EP patents, and greater than 100 global patents centered around therapeutic development. She has also authored forty-six peer-reviewed publications. Dr. Cardarelli received her Ph.D. in Physiology from Albany Medical College.     

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Dr. Josephine (Pina) Cardarelli on the web

LinkedIn 

https://www.linkedin.com/in/josephine-pina-cardarelli/

Website  

http://gpcr.co.kr/

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Imagine a world in which the vast majority of us are healthy.

The #DrGPCR Ecosystem is all about dynamic interactions between us who are working towards exploiting the druggability of #GPCR's. We aspire to provide opportunities to connect, share, form trusting partnerships, grow, and thrive together.

To build our #GPCR Ecosystem, we created various enabling outlets.

For more details, visit our website http://www.DrGPCR.com/Ecosystem/.

-------------------------------------------

Are you a #GPCR professional?

- Register to become a Virtual Cafe speaker

http://www.drgpcr.com/virtual-cafe/

-   Subscribe to our Monthly Newsletter

http://www.drgpcr.com/newsletter/

-   Listen and subscribe to #DrGPCR Podcasts

To read the full #Newsletter click here:

https://www.drgpcr.com/january-2022/

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Imagine a world in which the vast majority of us are healthy.

The #DrGPCR Ecosystem is all about dynamic interactions between us who are working towards exploiting the druggability of #GPCR's. We aspire to provide opportunities to connect, share, form trusting partnerships, grow, and thrive together.

To build our #GPCR Ecosystem, we created various enabling outlets.

For more details, visit our website http://www.DrGPCR.com/Ecosystem/.

For more details, visit #DrGPCPodcast Episode #59 page 

https://www.drgpcr.com/episode-59-with-nicola-j-smith/

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About Dr. Nicola J. Smith      

Dr. Nicola J Smith is an expert in molecular pharmacology with a track record in exploring GPCR structure-function relationships in the context of cardiovascular disease and metabolic disorders. She is a National Heart Foundation of Australia Future Leader Fellow and runs a laboratory of 7 Ph.D. and Honours students at UNSW Sydney, where she has recently been promoted to Associate Professor. Most recently, Dr. Smith’s team has made advances in the understanding of how an orphan GPCR exerts its effects both in vitro (cell culture and ex vivo models) and in vivo (measures of physiological and pathological cardiometabolic function in unconscious and conscious mice). Together with Irina Kufareva, UCSD, her team developed a novel approach to identifying ligands for orphan GPCRs by developing a powerful new computational tool for identifying ‘surrogate’ ligands (borrowed from other receptors) for orphan GPCRs, named GPCR-CoINPocket. Her career goal is to leverage this expertise to establish a research program that takes orphan GPCRs from ‘locked’, inaccessible receptors to well-characterized and understood ‘unlocked’ therapeutic targets with high-affinity ligands. 

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Dr. Nicola J. Smith on the web             

UNSW Sydney 

https://med.unsw.edu.au/our-people/nicola-smith

LinkedIn 

https://med.unsw.edu.au/our-people/nicola-smith

Retraction Watch 

https://retractionwatch.com/2021/01/12/the-most-horrific-time-of-my-career/

Retraction Watch 

https://retractionwatch.com/2021/01/12/the-most-horrific-time-of-my-career/Twitter      

https://twitter.com/smith_orphans

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Imagine a world in which the vast majority of us are healthy.

The #DrGPCR Ecosystem is all about dynamic interactions between us who are working towards exploiting the druggability of #GPCR's. We aspire to provide opportunities to connect, share, form trusting partnerships, grow, and thrive together.

To build our #GPCR Ecosystem, we created various enabling outlets.

For more details, visit our website http://www.DrGPCR.com/Ecosystem/.

-------------------------------------------

Are you a #GPCR professional?

- Register to become a Virtual Cafe speaker

http://www.drgpcr.com/virtual-cafe/

-   Subscribe to our Monthly Newsletter

http://www.drgpcr.com/newsletter/

-   Listen and subscribe to #DrGPCR Podcasts

http://www.drgpcr.com/podcast/

-   Support #DrGPCR Ecosystem with your Donation.

http://www.drgpcr.com/sponsors/

-   Reserve your spots for the next #DrGPCR Virtual Cafe

http://www.drgpcr.com/virtual-cafe/

-   Watch recorded #DRGPCR Virtual Cafe presentations:

https://www.youtube.com/channel/UCJvKL3smMEEXBulKdgT_yCw

- Bring in a #GPCR Consultant

http://www.drgpcr.com/consulting/