Dr. GPCR Podcast

Dr. GPCR Podcast

By Dr. Yamina BerchicheScienceLife Sciences
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Dr. GPCR Podcast episodes

  • #58 with Dr. Juan José Fung
    For more details, visit #DrGPCRPodcast Episode #58 page
    https://www.drgpcr.com/episode-58-with-juan-jose-fung/
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    About Dr. Juan José Fung

    Dr. Juan José Fung is a Principal Scientist at GPCR Therapeutics, Inc, a drug discovery company focused on targeting GPCR heteromers in cancer, headquartered in Seoul, Korea, with an R&D facility in the SF Bay Area. Dr. Fung received his Ph.D. from the Stanford University School of Medicine under the mentorship of Dr. Brian Kobilka, studying the dimerization of GPCRs. Dr. Fung continued his Postdoctoral training in Dr. Kobilka’s lab contributing to the elucidation of high-resolution structures of various GPCRs. Dr. Fung has spent significant time in the industry studying membrane proteins, antibodies, and HTS methods for drug discovery. His current work is mainly focused on screening and assay development to bridge the gap between in vitro and in vivo GPCR pharmacology.

    Dr. Juan José Fung on the web
    • LinkedIn
    • Website

      • -------------------------------------------

      Imagine a world in which the vast majority of us are healthy.

      The #DrGPCR Ecosystem is all about dynamic interactions between us who are working towards exploiting the druggability of #GPCR's. We aspire to provide opportunities to connect, share, form trusting partnerships, grow, and thrive together.

      To build our #GPCR Ecosystem, we created various enabling outlets.

      For more details, visit our website http://www.DrGPCR.com/Ecosystem/.

      -------------------------------------------

      Are you a #GPCR professional?

      - Register to become a Virtual Cafe speaker

      http://www.drgpcr.com/virtual-cafe/

      -   Subscribe to our Monthly Newsletter

      http://www.drgpcr.com/newsletter/

      -   Listen and subscribe to #DrGPCR Podcasts

      http://www.drgpcr.com/podcast/

      -   Support #DrGPCR Ecosystem with your Donation.

      http://www.drgpcr.com/sponsors/

      -   Reserve your spots for the next #DrGPCR Virtual Cafe

      http://www.drgpcr.com/virtual-cafe/

      -   Watch recorded #DRGPCR Virtual Cafe presentations:

      https://www.youtube.com/channel/UCJvKL3smMEEXBulKdgT_yCw

      -   Bring in a #GPCR Consultant

      http://www.drgpcr.com/consulting/


      55 min
    • #55 with Mark Schmeizl
      For more details, visit #DrGPCR Podcast Episode #55 page 
      https://www.drgpcr.com/episode-55-with-dr-mark-schmeizl/

      -------------------------------------------

      About Mark Schmeizl

      Mark leverages 30 years in various life science laboratories & commercial roles with his network of VC & PE contacts to help senior-level life science executives identify new opportunities. He has successfully built numerous global life science, leadership teams, & works closely with both clients & candidates to understand their unique needs & culture. Mark believes professional placement should be about matching talented people with companies where they will thrive, “when the match is right, the results are astonishing.”

      -------------------------------------------

      Imagine a world in which the vast majority of us are healthy.

      The #DrGPCR Ecosystem is all about dynamic interactions between us who are working towards exploiting the druggability of #GPCR's. We aspire to provide opportunities to connect, share, form trusting partnerships, grow, and thrive together.

      To build our #GPCR Ecosystem, we created various enabling outlets.

      For more details, visit our website http://www.DrGPCR.com/Ecosystem/.

      -------------------------------------------

      Are you a #GPCR professional?

      - Register to become a Virtual Cafe speaker

      http://www.drgpcr.com/virtual-cafe/

      -   Subscribe to our Monthly Newsletter

      http://www.drgpcr.com/newsletter/

      -   Listen and subscribe to #DrGPCR Podcasts

      http://www.drgpcr.com/podcast/

      -   Support #DrGPCR Ecosystem with your Donation.

      http://www.drgpcr.com/sponsors/

      -   Reserve your spots for the next #DrGPCR Virtual Cafe

      http://www.drgpcr.com/virtual-cafe/

      -   Watch recorded #DRGPCR Virtual Cafe presentations:

      https://www.youtube.com/channel/UCJvKL3smMEEXBulKdgT_yCw

      - Bring in a #GPCR Consultant

      http://www.drgpcr.com/consulting/

      -   Share your feedback with us:

      http://www.drgpcr.com/audience-survey/

      -   Become a #DrGPCR Ecosystem Member

      http://www.drgpcr.com/membership/


      1 hr 10 min
    • Newsletter - December 2021

      To read the full #Newsletter click here:

      https://www.drgpcr.com/december-2021/

      -------------------------------------------

      Imagine a world in which the vast majority of us are healthy.

      The #DrGPCR Ecosystem is all about dynamic interactions between us who are working towards exploiting the druggability of #GPCR's. We aspire to provide opportunities to connect, share, form trusting partnerships, grow, and thrive together.

      To build our #GPCR Ecosystem, we created various enabling outlets.

      For more details, visit our website http://www.DrGPCR.com/Ecosystem/.

      5 min
    • Newsletter - November 2021

      To read the full #Newsletter click here:

      https://www.drgpcr.com/november-2021/

      -------------------------------------------

      Imagine a world in which the vast majority of us are healthy.

      The #DrGPCR Ecosystem is all about dynamic interactions between us who are working towards exploiting the druggability of #GPCR's. We aspire to provide opportunities to connect, share, form trusting partnerships, grow, and thrive together.

      To build our #GPCR Ecosystem, we created various enabling outlets.

      For more details, visit our website http://www.DrGPCR.com/Ecosystem/.

      4 min
    • #57 with Dr. Peter Robert Banks

      For more details, visit #DrGPCR​​​ Podcast Episode #57 page:

      https://www.drgpcr.com/episode-57-with-dr-peter-robert-banks/

      -------------------------------------------


      About Dr. Peter Robert Banks

      Peter Banks is currently the Scientific Director at BioTek Instruments, now a part of Agilent. His responsibilities include the management of the company’s applications team and providing scientific guidance to the senior management team on new technology and emerging trends impacting life sciences. Before joining BioTek in 2008, Banks was employed by PerkinElmer for a decade. These roles included management of PerkinElmer’s BioPharma R&D program and Chair of the company’s Scientific Advisory Board. Prior to experiences at PerkinElmer and BioTek, Banks was an Assistant Professor in Analytical Chemistry at Concordia University, Montreal, Canada from 1994 to 1998.

      -------------------------------------------


      Imagine a world in which the vast majority of us are healthy.

      The #DrGPCR Ecosystem is all about dynamic interactions between us who are working towards exploiting the druggability of #GPCR's. We aspire to provide opportunities to connect, share, form trusting partnerships, grow, and thrive together.

      To build our #GPCR Ecosystem, we created various enabling outlets.

      For more details, visit our website http://www.DrGPCR.com/Ecosystem/.

      -------------------------------------------


      Are you a #GPCR professional?

      - Register to become a Virtual Cafe speaker

      http://www.drgpcr.com/virtual-cafe/

      -   Subscribe to our Monthly Newsletter

      http://www.drgpcr.com/newsletter/

      -   Listen and subscribe to #DrGPCR Podcasts

      http://www.drgpcr.com/podcast/

      -   Support #DrGPCR Ecosystem with your Donation.

      http://www.drgpcr.com/sponsors/

      -   Reserve your spots for the next #DrGPCR Virtual Cafe

      http://www.drgpcr.com/virtual-cafe/

      -   Watch recorded #DRGPCR Virtual Cafe presentations:

      https://www.youtube.com/channel/UCJvKL3smMEEXBulKdgT_yCw

      -   Bring in a #GPCR Consultant

      http://www.drgpcr.com/consulting/

      -   Share your feedback with us:

      http://www.drgpcr.com/audience-survey/

      -   Become a #DrGPCR Ecosystem Member

      http://www.drgpcr.com/membership/


      57 min
    • #56 with Dr. Adriano Marchese

      For more details, visit #DrGPCR​​​ Podcast Episode #56 page:

      http://www.drgpcr.com/episode-56-with-dr-adriano-marchese/

      -------------------------------------------

      Adriano Marchese is a Professor of Biochemistry at the Medical College of Wisconsin. Adriano received his Bachelor of Science degree in Pharmacology in 1991 from the University of Toronto. He continued his graduate studies at the University of Toronto where he earned his MSc (1994) and Ph.D. (1998) in Pharmacology. He then moved to Thomas Jefferson University in Philadelphia, PA, for his postdoctoral training in Jeff Benovic’s laboratory studying the regulation of G protein-coupled receptor trafficking and signaling. In 2004 Adriano joined the faculty of the Department of Pharmacology at Loyola University Chicago. In 2016 he decided to move his lab to the Medical College of Wisconsin in Milwaukee, WI.


      Adriano’s research has contributed to our understanding of the role that ubiquitin plays in GPCR signaling and trafficking. His laboratory is interested in understanding the mechanisms that govern spatial and temporal regulation of GPCR signaling by -arrestins and post-translational modifications (PTMs), such as phosphorylation, ubiquitination, and SUMOylation. His lab has shown a role for -arrestins and PTMs in GPCR trafficking and signaling and has leveraged this knowledge to reveal the spatial and temporal requirements for GPCR activation of signaling pathways related to cell survival, proliferation, and migration. The ultimate goal of Adriano’s research is to target novel aspects of GPCR signaling for therapeutic development.

      -------------------------------------------

      Imagine a world in which the vast majority of us are healthy.

      The #DrGPCR Ecosystem is all about dynamic interactions between us who are working towards exploiting the druggability of #GPCR's. We aspire to provide opportunities to connect, share, form trusting partnerships, grow, and thrive together.

      To build our #GPCR Ecosystem, we created various enabling outlets.

      For more details, visit our website http://www.DrGPCR.com/Ecosystem/

      -------------------------------------------

      Are you a #GPCR professional?

      - Register to become a Virtual Cafe speaker

      http://www.drgpcr.com/virtual-cafe/

      -   Subscribe to our Monthly Newsletter

      http://www.drgpcr.com/newsletter/

      -   Listen and subscribe to #DrGPCR Podcasts

      http://www.drgpcr.com/podcast/

      -   Support #DrGPCR Ecosystem with your Donation.

      http://www.drgpcr.com/sponsors/

      -   Reserve your spots for the next #DrGPCR Virtual Cafe

      http://www.drgpcr.com/virtual-cafe/

      1 hr 1 min
    • #54 with Dr. JoAnn Trejo
      About Dr. JoAnn Trejo

      Dr. JoAnn Trejo earned her Ph.D. at UC San Diego. She completed her postdoctoral fellowship at UC San Francisco under the guidance of Professor Shaun Coughlin where she worked on the newly discovered protease-activated GPCRs. Dr. Trejo joined the faculty in the Department of Pharmacology at the University of North Carolina in 2000 and then moved to UC San Diego School Medicine, Department of Pharmacology in 2008, where she quickly rose through the ranks to tenured professor in 2012. In 2014, she was appointed Vice-Chair of the Department of Pharmacology.


      The long-term goal of Dr. Trejo’s research program is to gain a thorough and mechanistic understanding of processes that control cell signaling by protease-activated receptors (PARs) and the impact on vascular inflammation and cancer progression. PARs are GPCRs that are activated through an atypical irreversible proteolytic mechanism. The precise control of PAR signaling is critical for proper temporal and spatial dynamics of signaling and appropriate cellular responses. Discovering new aspects of PAR signaling is important for increasing the fundamental knowledge of GPCR biology and for the identification of drug targets and future drug development. Dr. Trejo’s research has focused on PAR1, which has important functions in hemostasis, thrombosis, inflammation, and cancer and is an important drug target. She has made numerous important discoveries related to the mechanisms that control PAR1 signaling and closely related family members and published extensively on this topic. Dr. Trejo has been continuously funded by the NIH for >20 years and was a recipient of the prestigious American Heart Association Established Investigator Award. Her laboratory is the recognized expert on protease-activated receptors, particularly PAR1, and over the years she has discovered novel aspects of GPCR biology, acquired critical expertise, and rigorous approaches to examine PAR1 function using human cultured cells and mouse models. Dr. Trejo has presented her studies at 52 national/international meetings and 66 academic seminars across the U.S.

      -------------------------------------------

      Imagine a world in which the vast majority of us are healthy.

      The #DrGPCR Ecosystem is all about dynamic interactions between us who are working towards exploiting the druggability of #GPCR's. We aspire to provide opportunities to connect, share, form trusting partnerships, grow, and thrive together.

      To build our #GPCR Ecosystem, we created various enabling outlets.

      For more details, visit our website http://www.DrGPCR.com/Ecosystem/.

      -------------------------------------------


      Are you a #GPCR professional?

      - Register to become a Virtual Cafe speaker

      http://www.drgpcr.com/virtual-cafe/

      -   Subscribe to our Monthly Newsletter

      http://www.drgpcr.com/newsletter/

      -   Listen and subscribe to #DrGPCR Podcasts

      http://www.drgpcr.com/podcast/

      -   Support #DrGPCR Ecosystem with your Donation.

      http://www.drgpcr.com/sponsors/

      -   Reserve your spots for the next #DrGPCR Virtual Cafe

      http://www.drgpcr.com/virtual-cafe/

      -   Watch recorded #DRGPCR Virtual Cafe presentations:

      https://www.youtube.com/channel/UCJvKL3smMEEXBulKdgT_yCw

      -   Bring in a #GPCR Consultant

      http://www.drgpcr.com/consulting/

      - &

      1 hr 6 min
    • Newsletter - October 2021

      To read the full #Newsletter click here:

      https://www.drgpcr.com/october-2021/

      -------------------------------------------

      Imagine a world in which the vast majority of us are healthy.

      The #DrGPCR Ecosystem is all about dynamic interactions between us who are working towards exploiting the druggability of #GPCR's. We aspire to provide opportunities to connect, share, form trusting partnerships, grow, and thrive together.

      To build our #GPCR Ecosystem, we created various enabling outlets.

      For more details, visit our website http://www.DrGPCR.com/Ecosystem/.

      -------------------------------------------

      Are you a #GPCR professional?

      - Register to become a Virtual Cafe speaker

      http://www.drgpcr.com/virtual-cafe/

      -   Subscribe to our Monthly Newsletter

      http://www.drgpcr.com/newsletter/

      -   Listen and subscribe to #DrGPCR Podcasts

      http://www.drgpcr.com/podcast/

      -   Support #DrGPCR Ecosystem with your Donation.

      http://www.drgpcr.com/sponsors/

      -   Reserve your spots for the next #DrGPCR Virtual Cafe

      http://www.drgpcr.com/virtual-cafe/

      -   Watch recorded #DRGPCR Virtual Cafe presentations:

      https://www.youtube.com/channel/UCJvKL3smMEEXBulKdgT_yCw

      -   Bring in a #GPCR Consultant

      http://www.drgpcr.com/consulting/

      -   Share your feedback with us:

      http://www.drgpcr.com/audience-survey/

      -   Become a #DrGPCR Ecosystem Member

      http://www.drgpcr.com/membership/

      3 min
    • #53 with Dr. Timo De Groof
      About Dr. Timo De Groof

      Dr. Timo De Groof studied Biochemistry and Biotechnology at the University of Ghent where he graduated in 2015. During his master's studies, he specialized in Biomedical Biotechnology and Structural Biology/Biochemistry. During his last year of studies, Timo performed research in the biopharmaceutical company Argen x and gained experience in the identification and characterization of llama-derived antibodies in inflammatory diseases and oncology.


      From 2015 to 2019, he completed his Ph.D. in the Medicinal Chemistry group at VU University Amsterdam under the supervision of prof. dr. Martine Smit. During his Ph.D., Timo, together with Dr. Raimond Heukers, developed a nanobody platform within the research group and used this platform to develop nanobodies targeting viral G protein-coupled receptors with a special focus on the human cytomegalovirus-encoded chemokine receptor US28. During his Ph.D., he used these nanobodies as research tools, to investigate different GPCR conformations, while also focusing on their therapeutic potential in oncology and transplant infectious disease.

      Starting from September 2019, Timo started working as a postdoctoral researcher at the Vrije Universiteit Brussel in the In Vivo Cellular and Molecular Imaging (ICMI) group that is focused on translational/clinical applications of nanobodies. He currently is focusing on the development of nanobody-based immunotracers as part of the IMI/EFPIA project entitled "Immune Image". Moreover, he is closely involved in multiple projects where he focuses on the generation of nanobodies against "difficult-to-target" proteins. In the near future, Timo hopes to combine his previous GPCR experience with his current focus to set up his own research line focusing on translational applications of GPCR-targeting nanobodies.

      -------------------------------------------

      Imagine a world in which the vast majority of us are healthy.

      The #DrGPCR Ecosystem is all about dynamic interactions between us who are working towards exploiting the druggability of #GPCR's. We aspire to provide opportunities to connect, share, form trusting partnerships, grow, and thrive together.

      To build our #GPCR Ecosystem, we created various enabling outlets.

      For more details, visit our website http://www.DrGPCR.com/Ecosystem/

      -------------------------------------------

      Are you a #GPCR professional?

      - Register to become a Virtual Cafe speaker

      http://www.drgpcr.com/virtual-cafe/

      -   Subscribe to our Monthly Newsletter

      http://www.drgpcr.com/newsletter/

      -   Listen and subscribe to #DrGPCR Podcasts

      http://www.drgpcr.com/podcast/

      -   Support #DrGPCR Ecosystem with your Donation.

      http://www.drgpcr.com/sponsors/

      -   Reserve your spots for the next #DrGPCR Virtual Cafe

      http://www.drgpcr.com/virtual-cafe/

      57 min
    • #52 with Dr. Benjamin Myers
      About Dr. Benjamin Myers

      Ben Myers is an assistant professor at the University of Utah School of Medicine in Salt Lake City, UT, and an investigator with the Huntsman Cancer Institute. Ben’s research focuses on Smoothened and other class F GPCRs which play essential roles in embryonic development and in cancer. His group studies the unusual signaling mechanisms employed by these atypical 7-transmembrane receptors, combining biochemical and structural approaches with cell biology and in vivo models. These studies have revealed new and unexpected ways for membrane lipids to regulate GPCR activity and for GPCRs to control intracellular kinases. More recently, Ben’s lab has begun studying GPCR signaling pathways that operate within the primary cilium, a tiny antenna-shaped structure at the cell surface with critical links to development, physiology, and disease.


      Ben studied developmental and cancer signaling as a postdoctoral fellow with Philip Beachy at Stanford University. Prior to that, Ben received his Ph.D. from UCSF in 2008, where he worked with David Julius on the structure, function, and physiology of ion channels and GPCRs in the nervous system.

      -------------------------------------------

      Imagine a world in which the vast majority of us are healthy.

      The #DrGPCR Ecosystem is all about dynamic interactions between us who are working towards exploiting the druggability of #GPCR's. We aspire to provide opportunities to connect, share, form trusting partnerships, grow, and thrive together.

      To build our #GPCR Ecosystem, we created various enabling outlets.

      For more details, visit our website http://www.DrGPCR.com/Ecosystem/

      -------------------------------------------

      Are you a #GPCR professional?

      - Register to become a Virtual Cafe speaker

      http://www.drgpcr.com/virtual-cafe/

      -   Subscribe to our Monthly Newsletter

      http://www.drgpcr.com/newsletter/

      -   Listen and subscribe to #DrGPCR Podcasts

      http://www.drgpcr.com/podcast/

      -   Support #DrGPCR Ecosystem with your Donation.

      http://www.drgpcr.com/sponsors/

      -   Reserve your spots for the next #DrGPCR Virtual Cafe

      http://www.drgpcr.com/virtual-cafe/

      1 hr 46 min

    About Dr. GPCR Podcast

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    We bring you closer to dedicated scientists who work tirelessly to help understand GPCR pathophysiology.

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