Dr. Jennifer Kates, SVP and Director, Global Health and HIV Policy Program, KFF, provides a tour d’horizon of how global health and health security look at day #98 of the Trump revolution. “The DOGE factor was not on my bingo card,” as it became the battering ram decimating institutions, programs, budgets and staff, far beyond what was environed in Project 2025. It went against what many Republicans favor—just look at the recent dismantling of the Millennium Challenge Corporation. The desire to vanquish likely emanates from the White House OMB. As the budget process, including recissions, advances, the power dynamic may shift to Congress. It may become possible to think about new ways to do foreign assistance. There will be no restoration of the status quo ante. It requires fresh thinking and clear principles, and most importantly, new forms of leadership.