For this episode, we discuss the roles and sensitivity of mitochondria with Dr. Richard Frye, MD, PhD. Dr. Frye received an MD and a PhD in Physiology and Biophysics from Georgetown University. He is board certified in Pediatrics, Neurology with special competence in Child Neurology, and as a Certified Principal Investigator. In addition, he has a Masters in Biomedical Sciences and Biostatistics from Drexel University. Dr. Frye has over 300 publications in leading journals and book chapters.

Dr. Frye shares many figures during the conversation so the listener can follow along.

Dr. Richard Frye https://drfryemdphd.com

Rossingnol Medical Center Facebook https://www.facebook.com/RossignolMedicalCenter

Neurological Health Foundation https://neurologicalhealth.org

Healthy Child Guide https://neurologicalhealth.org/the-guide-5/

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0:00 Dr. Richard Frye

0:58 Daylight Computer Company

5:17 Chroma Light Devices

8:27 History of Leucovorin; low risk, high reward; Folate Receptor Alpha (FRa)

10:25 Blood Brain Barrier; Folate; CSF (cerebral spinal fluid)

14:04 DNA, RNA; MTHFR (Methylenetetrahydrofolate reductase)

17:34 Cerebral Folate deficiency; BH4, Placenta & Womb

23:35 Folate deficiency & Autism

26:21 Clinical Studies & Data

29:28 Folate & Mitochondria; Cerebral Folate Antibodies; White Matter Findings (!)

34:45 Cerebral Folate deficiency & Ranges; Autistic Phenotypes: Language, Communication, & Behaviors

40:45 Language & Communication; Self-Injurious Behaviors; Hyperactivity, Agitation; Treatment duration

42:53 Folate Autoantibodies & Maternal Health & Markers

45:30 Studies & Behavioral outcomes; inflammation & thyroid findings

46:58 Neural development; Language connections, white matter tracts & distal connections

48:53 Leucovorin for different severity/levels of Autism; Spinal Bifida

51:08 Preparing for pregnancy

53:50 Transgenerational aspects of Folate Autoantibodies Research; Prenatal Care & Awareness

59:32 Guidance & Support

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Hopp: https://www.hopp.bio/fromthespectrum

YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuA

email: [email protected]