🚨New A2B Trial in JAMA!

Can 🧪dexmedetomidine or clonidine beat 💉propofol in sedating ICU patients on ventilators?

❌ No faster extubation

⚠️ More bradycardia & agitation

⚖️ Similar mortality

Verdict: No clear winner—tailor sedation to patient needs 🛌👨‍⚕️

#CriticalCare #ICU #SedationTrial

🚨🧠 BREAKING: Tenecteplase before thrombectomy boosts chances of stroke recovery!

💉 Faster reperfusion

📈 Higher functional independence (mRS 0–2 at 90d: 52.9% vs 44.1%)

⚠️ Slight ↑ in sICH, but no major safety red flags

🧪 #BRIDGE_TNK trial rewrites the stroke playbook!

#Stroke #Tenecteplase #NeuroTwitter

Nāgārjuna (c. 150 – c. 250 CE) was an Indian Buddhist monk and philosopher, regarded as the founder of the Madhyamaka (Middle Way) school of Mahāyāna Buddhism.

His most famous work, Mūlamadhyamakakārikā (Root Verses on the Middle Way), presents the concept of śūnyatā (emptiness) and the two truths doctrine, emphasizing dependent origination and rejecting inherent existence.

Nāgārjuna's philosophy has profoundly influenced Mahāyāna thought and continues to shape Buddhist studies and practice today.

📢 New RCT in Nature Medicine 🎯

Can zapping low-voltage areas (LVAs) reduce AF recurrence after PVI?

🔬 SUPPRESS-AF Trial

👥 342 pts with persistent AF

📉 1-yr AF/AT-free: 61% (PVI+LVA) vs 50% (PVI)

❌ Not statistically significant

🧠 Subgroup benefit in high-risk pts

#EPeeps #AFib #CardioTwitter 🫀

🧠💪 Can blood biomarkers of Alzheimer's predict who'll lose muscle strength with age?

In a 12-year study, higher p-tau, NfL & GFAP levels forecasted faster decline in grip & leg power — even before dementia onset.

🧬🪑✊ #Aging #Alzheimers #Sarcopenia #Biomarkers #Longevity

📉 New JAMA study tracks U.S. #SedentaryBehavior from 2013–2023:

🪑 Sitting time fell from 7.1 to 5.9 hrs/day pre-COVID

🦠 But plateaued post-pandemic at 6.0 hrs/day

🚶‍♀️ Progress stalled—time to get moving again!

#PublicHealth #NHANES #PhysicalActivity 🏃‍♂️📊🛋️

🐒 New study finds no disorganized attachment in wild chimpanzees!

🧠 Only secure & avoidant types observed—just like humans, but without the trauma.

🌿 Evolution favors calm, connected bonds.

📍Taï National Park, Côte d'Ivoire

🔗 Nature knows best. #PrimateScience #AttachmentTheory #Chimpanzees

💡World's tiniest pacemaker—smaller than a grain of rice!

🫀Leadless, wireless & bioresorbable

🔦 Powered by NIR light

🧬 Perfect for post-op pacing & TAVR

🌱 No wires, no scars, no removal!

#MedTech #Cardiology #Bioengineering #Innovation @Nature

Cutting cysteine = 🔥 30% weight loss in 7 days!

🧬 Triggers stress pathways (ISR/OSR)

❌ CoA & glutathione drop

🔥 Browning fat, futile cycling, energy drain

💡 Reversible & promising for obesity research!

#Metabolism #Obesity #AminoAcids #Science 🧪⚖️🧠

🚨 TAVI Trials Update!

🆚 COMPARE-TAVI 1: 🇮🇳Myval = 💪SAPIEN 3 in safety & efficacy

🆚 ACURATE IDE: ACURATE neo2 ❌not non-inferior to 💥SAPIEN/EVOLUT

📊 Valve wars intensify! #TAVI #HeartValve #Cardiology 🫀